Department of Clinical Embryology, Kasturba Medical College, Manipal

  • India

Research Output 1994 2020

  • 1154 Citations
  • 21 h-Index
  • 94 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
16 Citations (Scopus)

Nano-transfersomal formulations for transdermal delivery of asenapine maleate: in vitro and in vivo performance evaluations

Shreya, A. B., Managuli, R. S., Menon, J., Kondapalli, L., Hegde, A. R., Avadhani, K., Shetty, P. K., Amirthalingam, M., Kalthur, G. & Mutalik, S., 02-07-2016, In : Journal of Liposome Research. 26, 3, p. 221-232 12 p.

Research output: Contribution to journalArticle

Biological Availability
Skin
Deoxycholic Acid
Phosphatidylcholines
Ethanol
25 Citations (Scopus)

NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: A new biomarker for assessment of embryo implantation potential

Pudakalakatti, S. M., Uppangala, S., D'Souza, F., Kalthur, G., Kumar, P., Adiga, S. K. & Atreya, H. S., 01-2013, In : NMR in Biomedicine. 26, 1, p. 20-27 8 p.

Research output: Contribution to journalArticle

Assisted Reproductive Techniques
Blastocyst
Biomarkers
Pyruvic Acid
Metabolism
9 Citations (Scopus)
Herpes Zoster
DNA Fragmentation
Mental Competency
Spermatozoa
Zona Pellucida
2 Citations (Scopus)
Oocyte Retrieval
Reproduction
Pressure
Pregnancy Outcome
Intracytoplasmic Sperm Injections
1 Citation (Scopus)

Oocytes recovered after ovarian tissue slow freezing have impaired H2AX phosphorylation and functional competence

Sudhakaran, S., Uppangala, S., Salian, S. R., Honguntikar, S. D., Nair, R., Kalthur, G. & Adiga, S. K., 2015, In : Reproduction, Fertility and Development. 27, 8, p. 1242-1248 7 p.

Research output: Contribution to journalArticle

Mental Competency
Freezing
Oocytes
phosphorylation
freezing
16 Citations (Scopus)

Ovarian tissue vitrification is more efficient than slow freezing in protecting oocyte and granulosa cell DNA integrity

Mathias, F. J., D'souza, F., Uppangala, S., Salian, S. R., Kalthur, G. & Adiga, S. K., 01-12-2014, In : Systems Biology in Reproductive Medicine. 60, 6, p. 317-322 6 p.

Research output: Contribution to journalArticle

Vitrification
Granulosa Cells
Freezing
Oocytes
DNA
36 Citations (Scopus)

p21 provides stage specific DNA damage control to preimplantation embryos

Adiga, S. K., Toyoshima, M., Shiraishi, K., Shimura, T., Takeda, J., Taga, M., Nagai, H., Kumar, P. & Niwa, O., 13-09-2007, In : Oncogene. 26, 42, p. 6141-6149 9 p.

Research output: Contribution to journalArticle

Blastocyst
DNA Damage
Embryonic Structures
Apoptosis
Spermatozoa
1 Citation (Scopus)

Paternal DNA damage suppresses in vitro proliferation of mouse inner cell mass

Adiga, S. K., Toyoshima, M., Shimura, T., Takeda, J., Uematsu, N., Kumar, P. & Niwa, O., 2009, In : Journal of the Turkish German Gynecology Association. 10, 1, p. 6-9 4 p.

Research output: Contribution to journalArticle

DNA Damage
Spermatozoa
Embryonic Structures
Aptitude
DNA
1 Citation (Scopus)

Phase modulated 2D HSQC-TOCSY for unambiguous assignment of overlapping spin systems

Singh, A., Dubey, A., Adiga, S. K. & Atreya, H. S., 01-01-2018, In : Journal of Magnetic Resonance. 286, p. 10-16 7 p.

Research output: Contribution to journalArticle

culture media
Assisted Reproductive Techniques
Molecules
Metabolomics
embryos
3 Citations (Scopus)
Ceruloplasmin
Insemination
Acetylcholinesterase
Sulfhydryl Compounds
C-Reactive Protein
18 Citations (Scopus)

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

Khaw, A. K., Sameni, S., Venkatesan, S., Kalthur, G. & Hande, M. P., 01-11-2015, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 793, p. 86-95 10 p.

Research output: Contribution to journalArticle

Telomere
Brain Neoplasms
DNA Damage
Cell Death
Telomerase
40 Citations (Scopus)

Poor sperm quality and advancing age are associated with increased sperm DNA damage in infertile men

Varshini, J., Srinag, B. S., Kalthur, G., Krishnamurthy, H., Kumar, P., Rao, S. B. S. & Adiga, S. K., 05-2012, In : Andrologia. 44, SUPPL.1, p. 642-649 8 p.

Research output: Contribution to journalArticle

DNA Damage
Spermatozoa
Semen
Oligospermia
Varicocele

PPAR-gamma: A dagger in endometriosis

Amberkar, M. V., Meena Kumari, K., Mor, V., Semwal, A. & Adiga, S., 2010, In : Australasian Medical Journal. 3, 12, p. 814-820 7 p.

Research output: Contribution to journalArticle

Estradiol
Ovarian Hyperstimulation Syndrome
Oocytes
Serum
Intracytoplasmic Sperm Injections
16 Citations (Scopus)
Cymbopogon
Scavenging
DNA Damage
Free Radicals
Radiation

Proteinaceous sperm motility inhibitory factor from the female Indian garden lizard Calotes versicolor

Shankar, G., Uppangala, S., Adiga, S. K., Willard, B., Sagar, B. K. C., Titus, R. S. K. & Marathe, G. K., 01-01-2018, In : Reproduction, Fertility and Development. 30, 5, p. 744-751 8 p.

Research output: Contribution to journalArticle

Lizards
Sperm Motility
sperm motility
lizards
Spermatozoa
11 Citations (Scopus)

Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status

Adiga, S. K., Ehmcke, J., Schlatt, S., Kliesch, S., Westernströer, B., Luetjens, C. M., Wistuba, J. & Gromoll, J., 09-2011, In : Molecular Human Reproduction. 17, 9, p. 545-549 5 p., gar023.

Research output: Contribution to journalArticle

Germ Cells
Methylation
Spermatogenesis
5-Methylcytosine
Spermatocytes
32 Citations (Scopus)

Semen Abnormalities, Sperm DNA Damage and Global Hypermethylation in Health Workers Occupationally Exposed to Ionizing Radiation

Kumar, D., Salian, S. R., Kalthur, G., Uppangala, S., Kumari, S., Challapalli, S., Chandraguthi, S. G., Krishnamurthy, H., Jain, N., Kumar, P. & Adiga, S. K., 29-07-2013, In : PLoS One. 8, 7, e69927.

Research output: Contribution to journalArticle

Ionizing radiation
health care workers
Ionizing Radiation
Semen
ionizing radiation
29 Citations (Scopus)

Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S. M., Hariharapura, R. C., Kalthur, G., Udupa, N. & Mutalik, S., 03-02-2017, In : Drug Delivery. 24, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Antioxidants
Radiation
Skin
Differential Scanning Calorimetry
1 Citation (Scopus)

Spent embryo culture medium metabolites are related to the in vitro attachment ability of blastocysts

D’Souza, F., Uppangala, S., Asampille, G., Salian, S. R., Kalthur, G., Talevi, R., Atreya, H. S. & Adiga, S. K., 01-12-2018, In : Scientific Reports. 8, 1, 17025.

Research output: Contribution to journalArticle

Blastocyst
Culture Media
Embryonic Structures
Pyruvic Acid
Injections
13 Citations (Scopus)

Sperm abnormalities induced by pre-pubertal exposure to cyclophosphamide are effectively mitigated by Moringa oleifera leaf extract

Nayak, G., Vadinkar, A., Nair, S., Kalthur, S. G., D'Souza, A. S., Shetty, P. K., Mutalik, S., Shetty, M. M., Kalthur, G. & Adiga, S. K., 01-03-2016, In : Andrologia. 48, 2, p. 125-136 12 p.

Research output: Contribution to journalArticle

Moringa oleifera
Cyclophosphamide
Spermatozoa
Injections
DNA Damage
6 Citations (Scopus)

Spermatozoada dna hasari{dotless}ni{dotless}n boyutu ile fertilizasyon ve implantasyon öncesi embriyolari{dotless}n gelişimsel kompetansi{dotless} arasi{dotless}ndaki ilişki

Translated title of the contribution: Association between the extent of DNA damage in the spermatozoa, fertilization and developmental competence in preimplantation stage embryosUpadhya, D., Kalthur, G., Kumar, P., Rao, B. S. & Adiga, S. K., 2010, In : Journal of the Turkish German Gynecology Association. 11, 4, p. 182-186 5 p.

Research output: Contribution to journalArticle

Blastocyst
Fertilization
Mental Competency
DNA Damage
Spermatozoa
3 Citations (Scopus)

Sperm chromatin immaturity observed in short abstinence ejaculates affects DNA integrity and longevity in vitro

Uppangala, S., Mathai, S. E., Salian, S. R., Kumar, D., Singh, V. J., D'Souza, F., Kalthur, G., Kamath, A. & Adiga, S. K., 01-04-2016, In : PLoS One. 11, 4, e0152942.

Research output: Contribution to journalArticle

Chromatin
chromatin
Spermatozoa
spermatozoa
DNA
1 Citation (Scopus)

Sperm-derived factors enhance the in vitro developmental potential of haploid parthenotes

Nair, R., Aboobacker, S., Mutalik, S., Kalthur, G. & Adiga, S. K., 28-11-2017, (Accepted/In press) In : Zygote. p. 1-14 14 p.

Research output: Contribution to journalArticle

Haploidy
Spermatozoa
Oocytes
Status Epilepticus
Zygote
1 Citation (Scopus)

Sperm-mediated DNA lesions alter metabolite levels in spent embryo culture medium

Souza, F. D., Asampille, G., Uppangala, S., Kalthur, G., Atreya, H. S. & Adiga, S. K., 01-01-2019, In : Reproduction, Fertility and Development. 31, 3, p. 443-450 8 p.

Research output: Contribution to journalArticle

embryo culture
Culture Media
Spermatozoa
embryo (animal)
Embryonic Structures
46 Citations (Scopus)
DNA Damage
Spermatozoa
In Situ Nick-End Labeling
Oligospermia
Transferases
3 Citations (Scopus)

Successful in vitro growth of rat two-cell embryos to blastocysts using a simple chemically defined medium

Goh, V. H. H., Adiga, S. K., Tain, C. F., Tong, T. Y. Y. & Ng, S. C., 2000, In : Journal of Pharmacological and Toxicological Methods. 43, 3, p. 171-175 5 p.

Research output: Contribution to journalArticle

Blastocyst
Rats
Embryonic Structures
Glucose
Glutamine
3 Citations (Scopus)

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Joshi, H., Hegde, A. R., Shetty, P. K., Gollavilli, H., Managuli, R. S., Kalthur, G. & Mutalik, S., 01-01-2018, In : Photodermatology Photoimmunology and Photomedicine. 34, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

Sunscreening Agents
Nanoparticles
Skin
In Vitro Techniques
naringenin

Supplementation of biotin to sperm preparation medium enhances fertilizing ability of spermatozoa and improves preimplantation embryo development

Salian, S. R., Nayak, G., Kumari, S., Patel, S., Gowda, S., Shenoy, Y., Sugunan, S., G.K, R., Managuli, R. S., Mutalik, S., Dahiya, V., Pal, S., Adiga, S. K. & Kalthur, G., 15-02-2019, In : Journal of Assisted Reproduction and Genetics. 36, 2, p. 255-266 12 p.

Research output: Contribution to journalArticle

Biotin
Embryonic Development
Spermatozoa
Pentoxifylline
Fertilization
8 Citations (Scopus)

Supplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa

Kalthur, G., Salian, S. R., Keyvanifard, F., Sreedharan, S., Thomas, J. S., Kumar, P. & Adiga, S. K., 07-2012, In : Journal of Assisted Reproduction and Genetics. 29, 7, p. 631-635 5 p.

Research output: Contribution to journalArticle

Biotin
Pentoxifylline
Spermatozoa
Semen
Semen Preservation
8 Citations (Scopus)

Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa

Isaac, A. V., Kumari, S., Nair, R., Urs, D. R., Salian, S. R., Kalthur, G., Adiga, S. K., Manikkath, J., Mutalik, S., Sachdev, D. & Pasricha, R., 16-12-2017, In : Biochemical and Biophysical Research Communications. 494, 3-4, p. 656-662 7 p.

Research output: Contribution to journalArticle

Zinc Oxide
Cryopreservation
Nanoparticles
Spermatozoa
Fluorescence microscopy
26 Citations (Scopus)

Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint

Shimura, T., Toyoshima, M., Adiga, S. K., Kunoh, T., Nagai, H., Shimizu, N., Inoue, M. & Niwa, O., 28-09-2006, In : Oncogene. 25, 44, p. 5921-5932 12 p.

Research output: Contribution to journalArticle

S Phase
DNA Damage
Fibroblasts
Proliferating Cell Nuclear Antigen
DNA
21 Citations (Scopus)

Survey of fertility preservation options available to patients with cancer around the globe

Rashedi, A. S., De Roo, S. F., Ataman, L. M., Edmonds, M. E., Silva, A. A., Scarella, A., Horbaczewska, A., Anazodo, A., Arvas, A., De Carvalho, B. R., Sartorio, C., Beerendonk, C. C. M., Diaz-Garcia, C., Suh, C. S., Melo, C., Andersen, C. Y., Motta, E., Greenblatt, E. M., Van Moer, E., Zand, E. & 43 others, Reis, F. M., Sánchez, F., Terrado, G., Rodrigues, J. K., De Meneses e Silva, J. M., Smitz, J., Medrano, J., Lee, J. R., Winkler-Crepaz, K., Smith, K., Melo e Silva, L. H. F., Wildt, L., Salama, M., Del Mar Andrés, M., Bourlon, M. T., Vega, M., Chehin, M. B., De Vos, M., Khrouf, M., Suzuki, N., Azmy, O., Fontoura, P., Campos-Junior, P. H. A., Mallmann, P., Azambuja, R., Marinho, R. M., Anderson, R. A., Jach, R., Antunes, R. A., Mitchell, R., Fathi, R., Adiga, S. K., Takae, S., Kim, S. H., Romero, S., Grieco, S. C., Shaulov, T., Furui, T., Almeida-Santos, T., Nelen, W., Jayasinghe, Y., Sugishita, Y. & Woodruff, T. K., 01-03-2018, In : Journal of global oncology. 2018, 4

Research output: Contribution to journalArticle

Fertility Preservation
Neoplasms
Quality of Health Care
Practice Guidelines
Fertility
13 Citations (Scopus)

Survey of third-party parenting options associated with fertility preservation available to patients with cancer around the globe

Rashedi, A. S., De Roo, S. F., Ataman, L. M., Edmonds, M. E., Silva, A. A., Scarella, A., Horbaczewska, A., Anazodo, A., Arvas, A., De Carvalho, B. R., Sartorio, C., Beerendonk, C. C. M., Diaz-Garcia, C., Suh, C. S., Melo, C., Andersen, C. Y., Motta, E., Greenblatt, E. M., Van Moer, E., Zand, E. & 43 others, Reis, F. M., Sánchez, F., Terrado, G., Rodrigues, J. K., De Meneses e Silva, J. M., Smitz, J., Medrano, J., Lee, J. R., Winkler-Crepaz, K., Smith, K., Melo e Silva, L. H. F., Wildt, L., Salama, M., Del Mar Andrés, M., Bourlon, M. T., Vega, M., Chehin, M. B., De Vos, M., Khrouf, M., Suzuki, N., Azmy, O., Fontoura, P., Campos-Junior, P. H. A., Mallmann, P., Azambuja, R., Marinho, R. M., Anderson, R. A., Jach, R., Antunes, R. A., Mitchell, R., Fathi, R., Adiga, S. K., Takae, S., Kim, S. H., Romero, S., Grieco, S. C., Shaulov, T., Furui, T., Almeida-Santos, T., Nelen, W., Jayasinghe, Y., Sugishita, Y. & Woodruff, T. K., 01-03-2018, In : Journal of global oncology. 2018, 4

Research output: Contribution to journalArticle

Fertility Preservation
Parenting
Neoplasms
Assisted Reproductive Techniques
Pamphlets
6 Citations (Scopus)

Susceptibility of peripheral lymphocytes of brain tumour patients to in vitro radiation-induced DNA damage, a preliminary study

Kalthur, G., Kumar, P., Devi, U., Ali, S., Upadhya, R., Pillai, S. & Rao, A., 09-2008, In : Clinical and Experimental Medicine. 8, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

Lymphocytes
Brain Neoplasms
DNA Damage
Tumors
Brain
1 Citation (Scopus)

Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones

Meti, G. Y., Kamble, A. A., Kamble, R. R., Somagond, S. M., Devarajegowda, H. C., Kumari, S., Kalthur, G. & Adiga, S. K., 04-10-2016, In : European Journal of Medicinal Chemistry. 121, p. 221-231 11 p.

Research output: Contribution to journalArticle

Growth
Screening
indolin-2-one
In Vitro Techniques
2-oxindole
4 Citations (Scopus)

Synthesis of novel thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties

Castelino, P. A., Naik, P., Dasappa, J. P., Sujayraj, R. S., Sharath Chandra, K., Chaluvaiah, K., Nair, R., Sandya Kumari, M. V., Kalthur, G. & Adiga, S. K., 12-09-2014, In : European Journal of Medicinal Chemistry. 84, p. 194-199 6 p.

Research output: Contribution to journalArticle

Culicidae
Pyruvic Acid
Malaria
Ethanol
Nuclear magnetic resonance
7 Citations (Scopus)
DNA Damage
Spermatozoa
DNA
Fertilization
Research Design
17 Citations (Scopus)

Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes

Toyoshima, M., Shimura, T., Adiga, S. K., Taga, M., Shiraishi, K., Inoue, M., Yuan, Z. M. & Niwa, O., 05-05-2005, In : Oncogene. 24, 20, p. 3229-3235 7 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
Zygote
Spermatozoa
DNA
Phosphorylation
25 Citations (Scopus)
Germ Cells
Spermatozoa
Genomic Instability
DNA
DNA Damage
5 Citations (Scopus)

Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos

D'Souza, F., Pudakalakatti, S. M., Uppangala, S., Honguntikar, S., Salian, S. R., Kalthur, G., Pasricha, R., Appajigowda, D., Atreya, H. S. & Adiga, S. K., 17-11-2016, In : Scientific Reports. 6, 37291.

Research output: Contribution to journalArticle

metabolites
biomarkers
thymine
DNA
isoleucine
54 Citations (Scopus)

Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage

Kalthur, G., Raj, S., Thiyagarajan, A., Kumar, S., Kumar, P. & Adiga, S. K., 01-03-2011, In : Fertility and Sterility. 95, 3, p. 1149-1151 3 p.

Research output: Contribution to journalArticle

Sperm Motility
Semen
Vitamin E
Freezing
DNA Damage
2 Citations (Scopus)

yüzdürme ve dansite gradient ayi{dotless}rma metotlari{dotless}ni{dotless}n kombinasyonu DNA hasarli{dotless} spermleri etkili bir şekilde uzaklaşti{dotless}ri{dotless}r

Translated title of the contribution: Combination of swim-up and density gradient separation methods effectively eliminate DNA damaged spermGhumman, S., Adiga, S. K., Upadhya, D., Kalthur, G., Jayaraman, V., Rao, S. B. & Kumar, P., 2011, In : Journal of the Turkish German Gynecology Association. 12, 3, p. 148-152 5 p.

Research output: Contribution to journalArticle

Spermatozoa
DNA
Comet Assay
DNA Damage
Prospective Studies