Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

  • India

Research Output 1991 2020

2020

A Review on Anticancer Potentials of Benzothiazole Derivatives

Pathak, N., Rathi, E., Kumar, N., Kini, S. G. & Rao, C. M., 01-01-2020, In : Mini reviews in medicinal chemistry. 20, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Thiazoles
Cell Line
Neoplasms
Protein-Tyrosine Kinases

Design, Synthesis, Biological Evaluation and Molecular Dynamic Simulation Studies of Diphenyl Ether Derivatives as Antitubercular and Antibacterial Agents

Khade, A. B., Eshwara, V. K., Boshoff, H. I. M., Arora, K., Tiwari, A., Bhat, P., Tiwari, M. & Shenoy, G. G., 09-01-2020, In : ChemistrySelect. 5, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

Open Access
Phenyl Ethers
Antitubercular Agents
Pathogens
Bacilli
Escherichia coli

Design, synthesis, evaluation, and molecular dynamic simulation of triclosan mimic diphenyl ether derivatives as antitubercular and antibacterial agents

Khade, A. B., Boshoff, H. I. M., Arora, K., Vandana, K. E., Verma, R. & Shenoy, G. G., 01-01-2020, (Accepted/In press) In : Structural Chemistry.

Research output: Contribution to journalArticle

Triclosan
Antitubercular Agents
tuberculosis
Molecular dynamics
ethers
Urea
Atoms
Angiogenesis Inducing Agents
Free energy
Toxicity
1 Citation (Scopus)

Identifying the structural features of diphenyl ether analogues for inha inhibition: A 2D and 3D QSAR based study

Tiwari, A. P., Giliyar, V. B., Shenoy, G. G. & Eshwara, V. K., 01-01-2020, In : Letters in Drug Design and Discovery. 17, 1, p. 31-47 17 p.

Research output: Contribution to journalArticle

Quantitative Structure-Activity Relationship
Mycolic Acids
Dermatoglyphics
Type II Fatty Acid Synthase
Acyl Carrier Protein

Inhibition performances of spirocyclopropane derivatives for mild steel protection in HCl

Chafiq, M., Chaouiki, A., Lgaz, H., Salghi, R., Bhaskar, K. V., Marzouki, R., Bhat, K. S., Ali, I. H., Khan, M. I. & Chung, I. M., 01-03-2020, In : Materials Chemistry and Physics. 243, 122582.

Research output: Contribution to journalArticle

Carbon steel
Dione
steels
octanes
Derivatives
2019

An improved synthesis of latanoprost involving effective control on 15(S) diastereomer

Sasane, S. A., Bhise, N. B., Singh, G. P., Joseph, A. & Shenoy, G. G., 17-09-2019, In : Synthetic Communications. 49, 18, p. 2350-2356 7 p.

Research output: Contribution to journalArticle

latanoprost
Hydroxyl Radical
Crystallization
Purification

Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

Borase, B. B., Godbole, H. M., Singh, G. P., Upadhyay, P. R., Trivedi, A., Bhat, V. & Shenoy, G. G., 01-01-2019, (Accepted/In press) In : Synthetic Communications.

Research output: Contribution to journalArticle

Amides
Blood pressure
Pharmaceutical Preparations
quinapril
Open Access
Skin
Pharmaceutical Preparations
Drug Delivery Systems
Dialysis
Membranes
flavone
Cyclins
Quantitative Structure-Activity Relationship
Dermatoglyphics
Cyclin A

Catalytic asymmetric oxidation of sulfides to sulfoxides using (R)-6,6 -Diphenyl-BINOL as a chiral ligand

Maddireddy, N. V., Godbole, H. M., Singh, G. P., Kini, S. G. & Shenoy, G. G., 01-07-2019, In : Journal of Chemical Sciences. 131, 7, 64.

Research output: Contribution to journalArticle

Sulfoxides
Sulfides
Oxidants
Ligands
Oxidation

Cerotato de 1-triacontanol aislado de marsilea quadrifolia linn. Protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas

Translated title of the contribution: 1-triacontanol cerotate isolated from marsilea quadrifolia linn. Safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic ratsSnehunsu, A., Nayak, S. B., Kandwal, M., Piyali, A., Adiga, M., Sahoo, P., Medabala, T., Rao, K. R. & Joseph, A., 01-01-2019, In : International Journal of Morphology. 37, 1, p. 265-272 8 p.

Research output: Contribution to journalArticle

Open Access
Marsileaceae
Memory Disorders
Neurons
Anticonvulsants
Epilepsy
flavone
Cyclin A
Quantitative Structure-Activity Relationship
Hydrogen
Antineoplastic Agents
3 Citations (Scopus)
Antitubercular Agents
Phenyl Ethers
Tuberculosis
Derivatives
Vero Cells
Computer Simulation
MCF-7 Cells
Allosteric Site
Inhibitory Concentration 50
Cell Line

Design, synthesis, in silico and in vitro evaluation of novel diphenyl ether derivatives as potential antitubercular agents

Tiwari, A. P., Sridhar, B., Boshoff, H. I., Arora, K., Gautham Shenoy, G., Vandana, K. E. & Varadaraj Bhat, G., 01-01-2019, (Accepted/In press) In : Molecular Diversity.

Research output: Contribution to journalArticle

Acyl Carrier Protein
Antitubercular Agents
tuberculosis
Molecular modeling
Mycobacterium tuberculosis
Chalcones
Chalcone
Hydrophobic and Hydrophilic Interactions
Cell Line
Cyclin A

Designing of stable co-crystals of zoledronic acid using suitable coformers

Varma, A., Laxmi, P., Pai, A., Pai, G., Vasantharaju, S. G. & Sathyanarayana, M. B., 01-01-2019, In : Chemical and Pharmaceutical Bulletin. 67, 8, p. 816-823 8 p.

Research output: Contribution to journalArticle

Open Access
zoledronic acid
Solubility
Niacinamide
Crystals
Pharmaceutical Preparations
inhibitors
drugs
cancer
purines
Pharmaceutical Preparations
Chalcone
Proline
Esters
Catalysts
Malonates

Enhancement in Dissolution Rate of Atorvastatin Trihydrate Calcium by Formulating Its Porous Tablet Using Sublimation Technique

Singh, S. Y., Salwa, Shirodkar, R. K., Verma, R. & Kumar, L., 01-01-2019, (Accepted/In press) In : Journal of Pharmaceutical Innovation.

Research output: Contribution to journalArticle

Sublimation
Tablets
Pharmaceutical Preparations
Tensile Strength
Excipients
2 Citations (Scopus)
Molecular dynamics
Screening
Computer simulation
Throughput
Luteolin

Experimental data of fabricated co-crystals of doxorubicin HCl with flavonoids

Laxmi, P., Varma, A., Pai, A. & Sathyanarayana, M. B., 01-07-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 3, p. S225-S230

Research output: Contribution to journalArticle

Open Access
Flavonoids
Doxorubicin
Quercetin
Solubility
Drug Compounding
Open Access
Quinazolines
Quantitative Structure-Activity Relationship
Dermatoglyphics
Antineoplastic Agents
Drug Discovery
1 Citation (Scopus)

Flavones and their analogues as bioactive compounds – An overview

Jayashree, B. S., Venkatachalam, H. & Mallik, S. B., 01-01-2019, In : Mini-Reviews in Organic Chemistry. 16, 4, p. 377-391 15 p.

Research output: Contribution to journalReview article

flavone
Flavones
Flavonoids
Polyphenolic compounds
Solubility
1 Citation (Scopus)
Molecular dynamics
Ligands
Computer simulation
Proteins
Amino Acids
Quantitative Structure-Activity Relationship
Isoenzymes
Carbonic Anhydrase Inhibitors
Neoplasms
Databases
2 Citations (Scopus)

InCl 3 mediated heteroarylation of indoles and their derivatization via C[sbnd]H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

Sunke, R., Bankala, R., Thirupataiah, B., Ramarao, E. V. V. S., Kumar, J. S., Doss, H. M., Medishetti, R., Kulkarni, P., Kapavarapu, R. K., Rasool, M., Mudgal, J., Mathew, J. E., Shenoy, G. G., Parsa, K. V. L. & Pal, M., 15-07-2019, In : European Journal of Medicinal Chemistry. 174, p. 198-215 18 p.

Research output: Contribution to journalArticle

Indoles
Quinoxalines
Zebrafish
Multiple Sclerosis
Arthritis
Computer Simulation
Pyridine
Ethers
ethers
pyridines

In vitro and in vivo anticancer activity of semisynthetic derivatives of betulinic acid

Joseph, A., Srinivasan, K. K., Kutty, N. G., Moorkoth, S., Alex, A. T. & Maliyakkal, N., 01-01-2019, In : Latin American Journal of Pharmacy. 38, 8, p. 1582-1590 9 p.

Research output: Contribution to journalArticle

Diospyros
Cell Cycle Resting Phase
G1 Phase
Cell Cycle Checkpoints
HeLa Cells

In vitro antioxidant potential of microbial isolates from diverse habitats

Alex, A. T., Kamath, V., Rao, J. V., Udupa, N. & Joseph, A., 10-2019, In : Research Journal of Pharmacy and Technology. 12, 10, p. 4916-4920 5 p.

Research output: Contribution to journalArticle

Ecosystem
Antioxidants
Inhibitory Concentration 50
Superoxides
Sulfonic Acids

L-asparaginase from soil actinomycetes: Optimization of process variables using Plackett Burman method

Kumar, M., Muralidharan, A., Pai, A., Subrahmanyam, V. M. & Kamath, V., 07-2019, In : Research Journal of Pharmacy and Technology. 12, 7, p. 3487-3490 4 p.

Research output: Contribution to journalArticle

Asparaginase
Actinobacteria
Soil
Fermentation
Base Composition

Micronutrient and their role in stress related disorders

Samkutty, S., Venkatachalam, H. & Jayashree, B. S., 01-10-2019, In : International Journal of Pharmaceutical Research. 11, 4, p. 902-911 10 p.

Research output: Contribution to journalArticle

Micronutrients
Chemical Phenomena
Flavones
Food
Immune System Diseases
Molecular Dynamics Simulation
Vascular Endothelial Growth Factor A
Free energy
Molecular dynamics
Screening
Memory Disorders
Aluminum
Rats
Acetylcholinesterase
Data storage equipment

Novel isatin-indole derivatives as potential inhibitors of chorismate mutase (CM): Their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd-Cu catalysis

Reddy, G. S., Hossain, K. A., Kumar, J. S., Thirupataiah, B., Edwin, R. K., Giliyaru, V. B., Chandrashekhar Hariharapura, R., Shenoy, G. G., Misra, P. & Pal, M., 01-01-2019, In : RSC Advances. 10, 1, p. 289-297 9 p.

Research output: Contribution to journalArticle

Open Access
Chorismate Mutase
Isatin
Benzoates
Catalysis
Esters

Photodegradation of methylcobalamin and its determination in a commercial formulation

Chamle, A. H., Shane, N. L. J., Pai, A. & Muddukrishna, B. S., 01-01-2019, In : Indian Journal of Pharmaceutical Sciences. 81, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

Open Access
Photolysis
Light
Hydroxocobalamin
Drug Stability
Liquid Chromatography

Potentials of diphenyl ether scaffold as a therapeutic agent: A review

Kini, S. G., Rathi, E., Kumar, A. & Bhat, V., 01-01-2019, In : Mini-Reviews in Medicinal Chemistry. 19, 17, p. 1392-1406 15 p.

Research output: Contribution to journalReview article

Phenyl Ethers
nimesulide
Triclosan
Structure-Activity Relationship
Antiviral Agents
2 Citations (Scopus)
Skin
Pharmaceutical Preparations
Bipolar Disorder
Antipsychotic Agents
Biological Availability

Solubility enhancement of ticagrelor by co-crystal technology: Preparation, solid state characterization and solubility studies

Shane, N. L. J., Pai, A., Pai, G., Pai, V., Sg, V. & Sathyanarayana, M. B., 01-01-2019, In : Latin American Journal of Pharmacy. 38, 10, p. 2051-2056 6 p.

Research output: Contribution to journalArticle

Solubility
Quercetin
Technology
Pharmaceutical Preparations
Fourier Transform Infrared Spectroscopy
1 Citation (Scopus)
Triclosan
Molecular dynamics
Docks
Pharmacokinetics
Bacilli
Triclosan
Antitubercular Agents
Molecular Dynamics Simulation
Microbial Sensitivity Tests
Bacillus subtilis

Synthesis and characterization of novel chiral imidazolium and pyridinium ionic liquids derived from tartaric acid and 2-oxazolidinone

Nehate, S. P., Godbole, H. M., Singh, G. P., Mathew, J. E. & Shenoy, G. G., 03-05-2019, In : Synthetic Communications. 49, 9, p. 1173-1180 8 p.

Research output: Contribution to journalArticle

Oxazolidinones
Ionic Liquids
Sulfides
tartaric acid
Salts

Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM)

Reddy, G. S., Snehalatha, A. V., Edwin, R. K., Hossain, K. A., Giliyaru, V. B., Hariharapura, R. C., Gautham Shenoy, G., Misra, P. & Pal, M., 01-10-2019, In : Bioorganic Chemistry. 91, 103155.

Research output: Contribution to journalArticle

Chorismate Mutase
Catalysis
Derivatives
Antitubercular Agents
Cyclization
1 Citation (Scopus)
Epoxidation
Proline
Condensation
Catalysts
Epoxy Compounds

Targeting HIV-TB coinfection by developing novel piperidin-4-substituted imines: Design, synthesis, in vitro and in silico studies

Kumar, A., Revathi, R., Sriram, D., Curreli, F., Debnath, A. K., Pai, K. S. & Kini, S. G., 01-06-2019, In : Archiv der Pharmazie. 352, 6, 1800358.

Research output: Contribution to journalArticle

Imines
Coinfection
Computer Simulation
HIV
Anti-HIV Agents
2018
2 Citations (Scopus)
Tankyrases
Quantitative Structure-Activity Relationship
Dermatoglyphics
inhibitors
Electrons
5 Citations (Scopus)

Applications of co-crystals in pharmaceutical drugs

Rekdal, M., Pai, A., Choudhari, R. & Sathyanarayana, M. B., 01-01-2018, In : Systematic Reviews in Pharmacy. 9, 1, p. 55-57 3 p.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Textiles
Solubility
Industry
Salts

Applications of graph theory in molecular similarity measurements

Kamath, V. & Pai, A., 01-04-2018, In : Research Journal of Pharmacy and Technology. 11, 4, p. 1375-1377 3 p.

Research output: Contribution to journalArticle

Fingers
Drug Design
Drug Discovery

A review on manufacturing operations of solid dosage forms: Design and implementation on GMP systems in the manufacturing facility

Girish Pai, K., Kumar, T. C. S., Parida, D. P. & Joseph, A., 01-06-2018, In : Journal of Global Pharma Technology. 10, 6, p. 1-10 10 p.

Research output: Contribution to journalReview article

Dosage Forms
Quality Control
Licensure
Guidelines
Manufacturing and Industrial Facilities