Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal

  • India

  • Madhava Nagar, MCOPS Building

    576104 Manipal


Organization profile

Organisation profile

Department of Pharmacology at Manipal College of Pharmaceutical Sciences has top-drawer facilities for research in cancer, metabolic disorders, diabetes, inflammatory diseases, chemoprevention, tissue repair, and neuropharmacology. Faculty members, research scholars, and postgraduate students are actively involved in research projects. BPharm students in their fourth year are also nurtured for taking up short-term projects. Ample research proposals have received funding from government agencies, namely AICTE, DBT, and DST. The department has developed tie-up with several industries like Enovate Bio Life, Mumbai, Indus Biotech, Pune and Cholayil Private Limited, Chennai to undertake work on their drugs and formulations. Full-fledged cell culture lab (with Western blotting, flow cytometry, cell analyzer) caters to research needs. Technical skills in instrument handling (HPLC, electrophoresis, fluorescent imaging) is provided at the department.

Fruitful collaborations are established with Molecular Neurotherapy and Imaging Laboratory, Radiology and Neurology at Massachusetts General Hospital, Boston, USA, University of California, Irwin, USA and Griffith University, Australia.

Highlights of Notable contributions:

DHPO (2-(3,4-Dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate) a potent activator of AMPK was developed in Department of Pharmacology. The molecule is currently marked by Merck Life Science Pvt. Ltd., as an AMPK activator for investigational purpose.

Investigation has been carried out to establish the effectiveness of Indian receipe "Sambar" against animal models of cancer. The study highlights the importance of spices that are constant factor in Indian diet which are effective against disorders of inflammatroy origin. The work has won accolades from global research community.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Antioxidants Medicine & Life Sciences
Rats Chemical Compounds
Wistar Rats Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Derivatives Chemical Compounds
Flavonoids Medicine & Life Sciences
Cells Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2019

Terminalia tomentosa bark ameliorates inflammation and arthritis in carrageenan induced inflammatory model and freund's adjuvant-induced arthritis model in rats

Jitta, S. R., Daram, P., Gourishetti, K., Misra, C. S., Polu, P. R., Shah, A., Shreedhara, C. S., Nampoothiri, M. & Lobo, R., 01-01-2019, In : Journal of Toxicology. 2019, 7898914.

Research output: Contribution to journalArticle

Experimental Arthritis
Freund's Adjuvant

Amelioration of arsenic-induced oxidative stress in CHO cells by Ixora coccinea flower extract

Salmataj, S. A., Kamath, S. U., Murty, V. R. & Pai, S. R., 01-10-2018, In : 3 Biotech. 8, 10, 446.

Research output: Contribution to journalArticle

Ixora coccinea
CHO Cells

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 03-10-2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)