Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal

  • India

  • Madhava Nagar, MCOPS Building

    576104 Manipal

    India

Research Output 1991 2019

2019

Annona muricata fruit extract protects against diethylnitrosamine-induced hepatocellular cancer in rats

Thomas, S., Paul, J., Shrungeswara, A., Biswas, S., Shah, A., Subraya, C. & Nayak, Y., 01-06-2019, In : Asian Pacific Journal of Tropical Medicine. 12, 6, p. 272-282 11 p.

Research output: Contribution to journalArticle

Annona
Diethylnitrosamine
Liver Neoplasms
Fruit
Chloroform
Caesalpinia
Hep G2 Cells
Acetaminophen
Glutathione
Genes

Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice

Sahu, P., Mudgal, J., Arora, D., Kinra, M., Mallik, S. B., Rao, C. M., Pai, K. S. R. & Nampoothiri, M., 01-06-2019, In : Psychopharmacology. 236, 6, p. 1829-1838 10 p.

Research output: Contribution to journalArticle

Illness Behavior
Cannabinoid Receptors
Lipopolysaccharides
Oxidative Stress
Tumor Necrosis Factor-alpha

Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In : Biomedical Reports. 11, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Catechin
Sprague Dawley Rats
Rats
Oxidative Stress
Fatty Liver
G-Protein-Coupled Receptors
Triglycerides
Liver
Oxidative Stress

Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders

Eapen, P. M., Rao, C. M. & Nampoothiri, M., 01-04-2019, In : Reviews in the Neurosciences. 30, 3, p. 233-243 11 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Nervous System Diseases
Substance P
Neurokinin-1 Receptor Antagonists
Physiological Phenomena
Open Access
Trigonella
High Fat Diet
Seeds
Hematocrit
Hemoglobins

Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats

Kinra, M., Arora, D., Mudgal, J., Pai, K. S. R., Mallikarjuna Rao, C. & Nampoothiri, M., 01-04-2019, In : Pharmacology. 103, 5-6, p. 315-319 5 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Reperfusion
Ischemia
Celecoxib
Kidney
Chitosan
Oligosaccharides
Nanoparticles
Cyclophosphamide
Chitin

Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats

Kumar, N., Rai, A., Reddy, N. D., Shenoy, R. R., Mudgal, J., Bansal, P., Mudgal, P. P., Arumugam, K., Udupa, N., Sharma, N. & Rao, C. M., 01-08-2019, In : Pharmacological Reports. 71, 4, p. 703-712 10 p.

Research output: Contribution to journalArticle

Silymarin
Liposomes
Wistar Rats
Alcohols
Biological Availability

InCl 3 mediated heteroarylation of indoles and their derivatization via C[sbnd]H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

Sunke, R., Bankala, R., Thirupataiah, B., Ramarao, E. V. V. S., Kumar, J. S., Doss, H. M., Medishetti, R., Kulkarni, P., Kapavarapu, R. K., Rasool, M., Mudgal, J., Mathew, J. E., Shenoy, G. G., Parsa, K. V. L. & Pal, M., 15-07-2019, In : European Journal of Medicinal Chemistry. 174, p. 198-215 18 p.

Research output: Contribution to journalArticle

Indoles
Quinoxalines
Zebrafish
Multiple Sclerosis
Arthritis

Medhya rasayana restores memory function against doxorubicin-induced cognitive decline: Possibly by its neuroprotective effect

Gourishetti, K., Ghetia, S., Jacob, L., Mallik, S. B., Nayak, P. G., Kishore, A., Nandakumar, K., Alnaseer, S. M. & Hussain, S. M., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S104-S111

Research output: Contribution to journalArticle

Open Access
Neuroprotective Agents
Doxorubicin
G2 Phase
Cell Division
Therapeutics
Memory Disorders
Aluminum
Rats
Acetylcholinesterase
Data storage equipment
1 Citation (Scopus)

Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Nigade, P. B., Gundu, J., Pai, K. S., Nemmani, K. V. S. & Talwar, R., 04-05-2019, In : Xenobiotica. 49, 5, p. 528-539 12 p.

Research output: Contribution to journalArticle

Tissue
Organ Size
Tissue Distribution
Individuality
Rodentia

Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In : Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Rutin
Doxorubicin
Rats
Breast Neoplasms

Sesamol and health - A comprehensive review

Shah, A., Lobo, R., Krishnadas, N. & Surubhotla, R., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S28-S42

Research output: Contribution to journalReview article

Open Access
Health
Anti-Inflammatory Agents
Antioxidants
Skin
sesamol

Targeting HIV-TB coinfection by developing novel piperidin-4-substituted imines: Design, synthesis, in vitro and in silico studies

Kumar, A., Revathi, R., Sriram, D., Curreli, F., Debnath, A. K., Pai, K. S. & Kini, S. G., 01-06-2019, In : Archiv der Pharmazie. 352, 6, 1800358.

Research output: Contribution to journalArticle

Imines
Coinfection
Computer Simulation
HIV
Anti-HIV Agents
1 Citation (Scopus)

Terminalia tomentosa bark ameliorates inflammation and arthritis in carrageenan induced inflammatory model and freund's adjuvant-induced arthritis model in rats

Jitta, S. R., Daram, P., Gourishetti, K., Misra, C. S., Polu, P. R., Shah, A., Shreedhara, C. S., Nampoothiri, M. & Lobo, R., 01-01-2019, In : Journal of Toxicology. 2019, 7898914.

Research output: Contribution to journalArticle

Terminalia
Experimental Arthritis
Freund's Adjuvant
Carrageenan
Arthritis

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

Kanwal, A., Pillai, V. B., Samant, S., Gupta, M. & Gupta, M. P., 12-07-2019, In : FASEB Journal. p. fj201900767R

Research output: Contribution to journalArticle

GA-Binding Protein Transcription Factor
Sirtuins
Diabetic Cardiomyopathies
Obesity
High Fat Diet
2018

Amelioration of arsenic-induced oxidative stress in CHO cells by Ixora coccinea flower extract

Salmataj, S. A., Kamath, S. U., Murty, V. R. & Pai, S. R., 01-10-2018, In : 3 Biotech. 8, 10, 446.

Research output: Contribution to journalArticle

Ixora coccinea
CHO Cells
Arsenic
arsenic
flower

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats

Chari, K. Y., Polu, P. R. & Shenoy, R. R., 01-01-2018, In : Journal of Toxicology. 2018, 6086490.

Research output: Contribution to journalArticle

Open Access
1,2-Dimethylhydrazine
Cucurbita
Colonic Neoplasms
Seed
Wistar Rats

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 03-10-2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticle

Macrophages
Antioxidants
Inflammation
Heme Oxygenase (Decyclizing)
Molecules

Antimicrobial activity of aqueous and ethanolic leaf extracts of anacardium occidentale

Shobha, K. L., Rao, A. S., Pai, K. S. R. & Bhat, S., 01-12-2018, In : Asian Journal of Pharmaceutical and Clinical Research. 11, 12, p. 474-476 3 p.

Research output: Contribution to journalArticle

Anacardium
Klebsiella pneumoniae
Escherichia coli
Enterococcus faecalis
Plant Extracts
2 Citations (Scopus)
Quinolinic Acid
Corpus Striatum
Huntington Disease
Lipid Peroxidation
Brain
10 Citations (Scopus)

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In : Cytotechnology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Episodic Memory
Catechin
Memory Disorders
Cytotoxicity
Doxorubicin
1 Citation (Scopus)

Chemically characterised extract of Saraca asoca improves the sexual function in male Wistar rats

Gill, M., Rai, A., Kinra, M., Sumalatha, S., Rao, C. M., Cheruku, S. P., Devkar, R. & Kumar, N., 01-09-2018, In : Andrologia. 50, 7, e13037.

Research output: Contribution to journalArticle

Wistar Rats
Sexual Behavior
Spermatozoa
Aphrodisiacs
Sperm Count
1 Citation (Scopus)
High Fat Diet
Fatty Liver
Nutrition
G-Protein-Coupled Receptors
Glucagon-Like Peptide 1
Sodium Glutamate
Nutrition
Medical problems
Type 2 Diabetes Mellitus
Blood Vessels
7 Citations (Scopus)

Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

Biswas, S. & Rao, C. M., 15-10-2018, In : European Journal of Pharmacology. 837, p. 8-24 17 p.

Research output: Contribution to journalReview article

Epigenomics
Neoplasms
Enzymes
Therapeutics
Chromatin
3 Citations (Scopus)

Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model

Gill, M., Kinra, M., Rai, A., Chamallamudi, M. R. & Kumar, N., 01-01-2018, In : NeuroReport. 29, 2, p. 134-140 7 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Antioxidants
Sucrose
Brain
Plant Bark
Thyroidectomy
Thyroxine
Pharmacokinetics
Radio
Thyroid Neoplasms
4 Citations (Scopus)

Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In : Journal of Ethnopharmacology. 210, p. 118-124 7 p.

Research output: Contribution to journalArticle

Tamarindus
Aphrodisiacs
Saponins
Phenol
Arousal
arsenate
Rutin
flower
Antioxidants
Traditional Medicine

Functional and therapeutic potential of mitochondrial SIRT3 deacetylase in disease conditions

Kanwal, A., 02-12-2018, In : Expert Review of Clinical Pharmacology. 11, 12, p. 1151-1155 5 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Heterocyclic homoprostanoid derivative attenuates monoarthritis in rats: An in vitro and in vivo preclinical paradigm

Mudgal, J., Manohara Reddy, S. A., Mathew, G., Kishore, A., Mallikarjuna Rao, C. & Nampurath, G. K., 01-01-2018, In : European Journal of Pharmaceutical Sciences. 111, p. 320-329 10 p.

Research output: Contribution to journalArticle

Interleukin-6
Lipopolysaccharides
Prostaglandin-Endoperoxide Synthases
Reactive Oxygen Species
Tarsal Joints

Knowns and unknowns about research on research

Nayak, Y., 2018, Research Reviews. Manipal Universal Press

Research output: Chapter in Book/Report/Conference proceedingChapter

field of study
invention
patent
morality
technical language

Modulatory role of mucuna pruriens against aluminium fluoride induced neuronal and behavioural alterations in rats

Nayak, V. S., Kumar, N., Dsouza, A. S., Nayak, S. S. & Pai, K. S. R., 01-04-2018, In : Journal of Clinical and Diagnostic Research. 12, 4, p. FC01-FC04

Research output: Contribution to journalArticle

Mucuna
Oxidative stress
Rats
Oxidative Stress
Quercetin
4 Citations (Scopus)

N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats

Fernandes, J., Mudgal, J., Rao, C. M., Arora, D., Basu Mallik, S., Pai, K. S. R. & Nampoothiri, M., 08-01-2018, (Accepted/In press) In : Toxicology Mechanisms and Methods. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptor Antagonists
Neurokinin-1 Receptors
Memory Disorders
Aluminum
Tryptophan
1 Citation (Scopus)

Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In : Pharmacognosy Magazine. 14, 55, p. S197-S207

Research output: Contribution to journalArticle

Doxorubicin
Episodic Memory
Locomotion
Reactive Oxygen Species
Flow Cytometry
1 Citation (Scopus)
Clitoria
Docosahexaenoic Acids
Choline
Oxidative Stress
Mothers
5-alpha Reductase Inhibitors
Quantitative Structure-Activity Relationship
Dihydrotestosterone
Oxidoreductases
Ligands

Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells

Kumar, N., Shrungeswara, A. H., Mallik, S. B., Biswas, S., Mathew, J., Nandakumar, K., Mathew, J. & Lobo, R., 01-01-2018, In : Anti-cancer agents in medicinal chemistry. 18, 11, p. 1563-1572 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Protein Kinases
Apoptosis
Hepatocellular Carcinoma
Phytochemicals

Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models

Nigade, P. B., Gundu, J., Pai, K. S. & Nemmani, K. V. S., 01-06-2018, In : European Journal of Drug Metabolism and Pharmacokinetics. p. 1-16 16 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Oral Administration
Spleen
Terminalia
Liver Diseases
Ethanol
Poisons
Liver
temozolomide
High Pressure Liquid Chromatography
Brain
formic acid
Pharmaceutical Preparations

Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity

Godipurge, S. S., Biradar, J. S., Biradar, N. J., Shivarudrappa, H. P., Yallappa, S., Hungund, B. S. & Sreedhara Ranganath Pai, K., 01-01-2018, In : Chemistry of Natural Compounds. 54, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

aerial parts
alkaloids
breast neoplasms
spectral analysis
cytotoxicity
3 Citations (Scopus)

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Verma, M. K., Goel, R., Krishnadas, N. & Nemmani, K. V. S., 03-07-2018, In : Expert Opinion on Therapeutic Targets. 22, 7, p. 615-628 14 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Cerebrovascular Disorders
Glucose
Peptides
Neurology
2017
6 Citations (Scopus)

5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells

Bokare, A. M., Praveenkumar, A. K., Bhonde, M., Nayak, Y., Pal, R. & Goel, R., 01-05-2017, In : Neurochemical Research. 42, 5, p. 1571-1579 9 p.

Research output: Contribution to journalArticle

Amyloid
Memantine
Reactive Oxygen Species
Peptides
Alzheimer Disease