Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal

  • India

  • Madhava Nagar, MCOPS Building

    576104 Manipal

    India

Research Output 1991 2019

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Article
2019
Fatty Liver
G-Protein-Coupled Receptors
Triglycerides
Liver
Oxidative Stress

InCl 3 mediated heteroarylation of indoles and their derivatization via C[sbnd]H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

Sunke, R., Bankala, R., Thirupataiah, B., Ramarao, E. V. V. S., Kumar, J. S., Doss, H. M., Medishetti, R., Kulkarni, P., Kapavarapu, R. K., Rasool, M., Mudgal, J., Mathew, J. E., Shenoy, G. G., Parsa, K. V. L. & Pal, M., 15-07-2019, In : European Journal of Medicinal Chemistry. 174, p. 198-215 18 p.

Research output: Contribution to journalArticle

Indoles
Quinoxalines
Zebrafish
Multiple Sclerosis
Arthritis
Memory Disorders
Aluminum
Rats
Acetylcholinesterase
Data storage equipment

Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Nigade, P. B., Gundu, J., Pai, K. S., Nemmani, K. V. S. & Talwar, R., 04-05-2019, In : Xenobiotica. 49, 5, p. 528-539 12 p.

Research output: Contribution to journalArticle

Tissue
Organ Size
Tissue Distribution
Individuality
Rodentia
1 Citation (Scopus)

Terminalia tomentosa bark ameliorates inflammation and arthritis in carrageenan induced inflammatory model and freund's adjuvant-induced arthritis model in rats

Jitta, S. R., Daram, P., Gourishetti, K., Misra, C. S., Polu, P. R., Shah, A., Shreedhara, C. S., Nampoothiri, M. & Lobo, R., 01-01-2019, In : Journal of Toxicology. 2019, 7898914.

Research output: Contribution to journalArticle

Terminalia
Experimental Arthritis
Freund's Adjuvant
Carrageenan
Arthritis
2018

Amelioration of arsenic-induced oxidative stress in CHO cells by Ixora coccinea flower extract

Salmataj, S. A., Kamath, S. U., Murty, V. R. & Pai, S. R., 01-10-2018, In : 3 Biotech. 8, 10, 446.

Research output: Contribution to journalArticle

Ixora coccinea
CHO Cells
Arsenic
arsenic
flower

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats

Chari, K. Y., Polu, P. R. & Shenoy, R. R., 01-01-2018, In : Journal of Toxicology. 2018, 6086490.

Research output: Contribution to journalArticle

Open Access
1,2-Dimethylhydrazine
Cucurbita
Colonic Neoplasms
Seed
Wistar Rats

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 03-10-2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticle

Macrophages
Antioxidants
Inflammation
Heme Oxygenase (Decyclizing)
Molecules

Antimicrobial activity of aqueous and ethanolic leaf extracts of anacardium occidentale

Shobha, K. L., Rao, A. S., Pai, K. S. R. & Bhat, S., 01-12-2018, In : Asian Journal of Pharmaceutical and Clinical Research. 11, 12, p. 474-476 3 p.

Research output: Contribution to journalArticle

Anacardium
Klebsiella pneumoniae
Escherichia coli
Enterococcus faecalis
Plant Extracts
1 Citation (Scopus)
Quinolinic Acid
Corpus Striatum
Huntington Disease
Lipid Peroxidation
Brain
9 Citations (Scopus)

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In : Cytotechnology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Episodic Memory
Catechin
Memory Disorders
Cytotoxicity
Doxorubicin
1 Citation (Scopus)

Chemically characterised extract of Saraca asoca improves the sexual function in male Wistar rats

Gill, M., Rai, A., Kinra, M., Sumalatha, S., Rao, C. M., Cheruku, S. P., Devkar, R. & Kumar, N., 01-09-2018, In : Andrologia. 50, 7, e13037.

Research output: Contribution to journalArticle

Wistar Rats
Sexual Behavior
Spermatozoa
Aphrodisiacs
Sperm Count
1 Citation (Scopus)
High Fat Diet
Fatty Liver
Nutrition
G-Protein-Coupled Receptors
Glucagon-Like Peptide 1
Sodium Glutamate
Nutrition
Medical problems
Type 2 Diabetes Mellitus
Blood Vessels
2 Citations (Scopus)

Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model

Gill, M., Kinra, M., Rai, A., Chamallamudi, M. R. & Kumar, N., 01-01-2018, In : NeuroReport. 29, 2, p. 134-140 7 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Antioxidants
Sucrose
Brain
Plant Bark
Thyroidectomy
Thyroxine
Pharmacokinetics
Radio
Thyroid Neoplasms
3 Citations (Scopus)

Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In : Journal of Ethnopharmacology. 210, p. 118-124 7 p.

Research output: Contribution to journalArticle

Tamarindus
Aphrodisiacs
Saponins
Phenol
Arousal
arsenate
Rutin
flower
Antioxidants
Traditional Medicine
1 Citation (Scopus)

Heterocyclic homoprostanoid derivative attenuates monoarthritis in rats: An in vitro and in vivo preclinical paradigm

Mudgal, J., Manohara Reddy, S. A., Mathew, G., Kishore, A., Mallikarjuna Rao, C. & Nampurath, G. K., 01-01-2018, In : European Journal of Pharmaceutical Sciences. 111, p. 320-329 10 p.

Research output: Contribution to journalArticle

Interleukin-6
Lipopolysaccharides
Prostaglandin-Endoperoxide Synthases
Reactive Oxygen Species
Tarsal Joints

Modulatory role of mucuna pruriens against aluminium fluoride induced neuronal and behavioural alterations in rats

Nayak, V. S., Kumar, N., Dsouza, A. S., Nayak, S. S. & Pai, K. S. R., 01-04-2018, In : Journal of Clinical and Diagnostic Research. 12, 4, p. FC01-FC04

Research output: Contribution to journalArticle

Mucuna
Oxidative stress
Rats
Oxidative Stress
Quercetin
4 Citations (Scopus)

N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats

Fernandes, J., Mudgal, J., Rao, C. M., Arora, D., Basu Mallik, S., Pai, K. S. R. & Nampoothiri, M., 08-01-2018, (Accepted/In press) In : Toxicology Mechanisms and Methods. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptor Antagonists
Neurokinin-1 Receptors
Memory Disorders
Aluminum
Tryptophan

Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In : Pharmacognosy Magazine. 14, 55, p. S197-S207

Research output: Contribution to journalArticle

Doxorubicin
Episodic Memory
Locomotion
Reactive Oxygen Species
Flow Cytometry
1 Citation (Scopus)
Clitoria
Docosahexaenoic Acids
Choline
Oxidative Stress
Mothers

Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells

Kumar, N., Shrungeswara, A. H., Mallik, S. B., Biswas, S., Mathew, J., Nandakumar, K., Mathew, J. & Lobo, R., 01-01-2018, In : Anti-cancer agents in medicinal chemistry. 18, 11, p. 1563-1572 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Protein Kinases
Apoptosis
Hepatocellular Carcinoma
Phytochemicals

Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models

Nigade, P. B., Gundu, J., Pai, K. S. & Nemmani, K. V. S., 01-06-2018, In : European Journal of Drug Metabolism and Pharmacokinetics. p. 1-16 16 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Oral Administration
Spleen
Terminalia
Liver Diseases
Ethanol
Poisons
Liver
temozolomide
High Pressure Liquid Chromatography
Brain
formic acid
Pharmaceutical Preparations

Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity

Godipurge, S. S., Biradar, J. S., Biradar, N. J., Shivarudrappa, H. P., Yallappa, S., Hungund, B. S. & Sreedhara Ranganath Pai, K., 01-01-2018, In : Chemistry of Natural Compounds. 54, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

aerial parts
alkaloids
breast neoplasms
spectral analysis
cytotoxicity
2017
4 Citations (Scopus)

5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells

Bokare, A. M., Praveenkumar, A. K., Bhonde, M., Nayak, Y., Pal, R. & Goel, R., 01-05-2017, In : Neurochemical Research. 42, 5, p. 1571-1579 9 p.

Research output: Contribution to journalArticle

Amyloid
Memantine
Reactive Oxygen Species
Peptides
Alzheimer Disease
1 Citation (Scopus)

An insight into the role of cyclooxygenase and lipooxygenase pathway in renal ischemia

Kinra, M., Mudgal, J., Arora, D. & Nampoothiri, M., 01-01-2017, In : European Review for Medical and Pharmacological Sciences. 21, 21, p. 5017-5020 4 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Ischemia
Kidney
Oxidative Stress
Inflammation Mediators

Anticancer activity of stem bark extract and fractions of Wrightia tinctoria in transplantable tumors in mice

Chaudhary, S., Setty, M. M. & Pai, K. S. R., 01-03-2017, In : Advanced Science Letters. 23, 3, p. 1995-2000 6 p.

Research output: Contribution to journalArticle

Ascites
tumor
bark
Mouse
Tumors
6 Citations (Scopus)
High Fat Diet
Fatty Liver
G-Protein-Coupled Receptors
Inbred C57BL Mouse
Fats
1 Citation (Scopus)
Oxadiazoles
MCF-7 Cells
Cytotoxicity
Caspase 2
Acridine Orange

Decitabine nanoparticles supplement docetaxel in the treatment of non-small cell lung cancer (NSCLC)

Jain, P., Kumar, N., Tiwari, M., Rao, J. V. & Udupa, N., 01-03-2017, In : Advanced Science Letters. 23, 3, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

decitabine
docetaxel
Lung Cancer
Non-Small Cell Lung Carcinoma
Nanoparticles
4 Citations (Scopus)

Development and in vivo evaluation of functionalized ritonavir proliposomes for lymphatic targeting

Ahammed, V., Narayan, R., Paul, J., Nayak, Y., Roy, B., Shavi, G. V. & Nayak, U. Y., 15-08-2017, In : Life Sciences. 183, p. 11-20 10 p.

Research output: Contribution to journalArticle

Ritonavir
Biotin
Particle Size
Liposomes
Biological Availability
5 Citations (Scopus)

Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

Verma, M. K., Goel, R., Nandakumar, K. & Nemmani, K. V. S., 05-06-2017, In : European Journal of Pharmacology. 804, p. 38-45 8 p.

Research output: Contribution to journalArticle

Dopamine
Corpus Striatum
Parkinson Disease
Brain
Gastric Inhibitory Polypeptide
6 Citations (Scopus)

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-05-2017, In : NeuroReport. 28, 9, p. 540-544 5 p.

Research output: Contribution to journalArticle

Dementia
Insulin
Rivastigmine
Frontal Lobe
Glucose

Evaluation of hepatoprotective effect of aqueous extract of Schrebera swietenioides bark against carbon tetrachloride-induced toxicity in wistar rats

Kumar, N., Choudhary, A., Tiwari, A., Rasal, A., Jetti, R. & Mallikarjuna Rao, C., 01-03-2017, In : Advanced Science Letters. 23, 3, p. 1917-1920 4 p.

Research output: Contribution to journalArticle

Carbon tetrachloride
Carbon Tetrachloride
Toxicants
Toxicity
Liver

Evaluation of in vitro and in vivo anticancer potential of two 5-acetamido chalcones against breast cancer

Wankhede, S., Kumar, N., Simon, L., Biswas, S., Gourishetti, K., Ramalingayya, G. V., Joshi, M. & Rao, C. M., 19-10-2017, In : EXCLI Journal. 16, p. 1150-1163 14 p.

Research output: Contribution to journalArticle

Chalcones
chalcones
Tumor Burden
breast neoplasms
Breast Neoplasms
19 Citations (Scopus)

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Pillai, V. B., Kanwal, A., Fang, Y. H., Sharp, W. W., Samant, S., Arbiser, J. & Gupta, M. P., 01-01-2017, In : Oncotarget. 8, 21, p. 34082-34098 17 p.

Research output: Contribution to journalArticle

Sirtuin 3
Heart Mitochondria
Cardiomyopathies
Doxorubicin
Neoplasms
2 Citations (Scopus)
Dementia
Rats
Insulin
Data storage equipment
Glucose
2 Citations (Scopus)
Oxidative stress
Episodic Memory
Doxorubicin
Wistar Rats
Rats
5 Citations (Scopus)
Chalcone
chalcone
Cell Cycle Checkpoints
colorectal neoplasms
Colonic Neoplasms

Long-term exposure to a butter-rich diet induces mild-to-moderate steatosis in Chang liver cells and Swiss albino mice models

Nalloor, T. J. P., Kumar, N., Narayanan, K. & Palanimuthu, V. R., 01-05-2017, In : Journal of Basic and Clinical Physiology and Pharmacology. 28, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Butter
Diet
Liver
Phosphoric Monoester Hydrolases
Fats
1 Citation (Scopus)

Modulation of doxorubicin-induced cardiotoxicity by averrhoa bilimbi extract

Francis, A. & Nayak, Y., 2017, In : Journal of Young Pharmacists. 9, 1, p. 70-78 9 p.

Research output: Contribution to journalArticle

Doxorubicin
Antioxidants
Ascites
Vero Cells
Carcinoma
2 Citations (Scopus)
Molecular modeling
Scaffolds
Histones
inhibitors
Screening

Phytochemical screening and antioxidant activity of Heracleum afghanicum Kitamura leaves

Amini, M. H., Kalsi, V., Kaur, B., Khatik, G. L., Lobo, R., Singh, G., Agarhari, U. C., Yele, S. & Suttee, A., 01-10-2017, In : Research Journal of Pharmacy and Technology. 10, 10, p. 3498-3502 5 p.

Research output: Contribution to journalArticle

Heracleum
Phytochemicals
Antioxidants
Flavonoids
Afghanistan
3 Citations (Scopus)

Pinocembrin enriched fraction of Elytranthe parasitica (L.) Danser induces apoptosis in HCT 116 colorectal cancer cells

Kumar, N., Biswas, S., Hosur Shrungeswara, A., Basu Mallik, S., Hipolith Viji, M., Elizabeth Mathew, J., Mathew, J., Nandakumar, K. & Lobo, R., 01-06-2017, In : Journal of Infection and Chemotherapy. 23, 6, p. 354-359 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Phytochemicals
Apoptosis
Cell Cycle Checkpoints
Gas Chromatography-Mass Spectrometry
2 Citations (Scopus)

Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP-HPLC method

Managuli, R. S., Gourishetti, K., Shenoy, R. R., Koteshwara, K. B., Reddy, M. S. & Mutalik, S., 01-07-2017, In : Bioanalysis. 9, 14, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Pharmacokinetics
High Pressure Liquid Chromatography
Tissue
Liquid-Liquid Extraction
Liquids