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Research Output 2001 2019

  • 486 Citations
  • 14 h-Index
  • 56 Article
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Article
2019
Caesalpinia
Hep G2 Cells
Acetaminophen
Glutathione
Genes

Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In : Biomedical Reports. 11, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Catechin
Sprague Dawley Rats
Rats
Oxidative Stress

Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats

Kumar, N., Rai, A., Reddy, N. D., Shenoy, R. R., Mudgal, J., Bansal, P., Mudgal, P. P., Arumugam, K., Udupa, N., Sharma, N. & Rao, C. M., 01-08-2019, In : Pharmacological Reports. 71, 4, p. 703-712 10 p.

Research output: Contribution to journalArticle

Silymarin
Liposomes
Wistar Rats
Alcohols
Biological Availability

Poly(N,N-diethyl acrylamide)/functionalized graphene quantum dots hydrogels loaded with doxorubicin as a nano-drug carrier for metastatic lung cancer in mice

Havanur, S., Batish, I., Cheruku, S. P., Gourishetti, K., JagadeeshBabu, P. E. & Kumar, N., 01-12-2019, In : Materials Science and Engineering C. 105, 110094.

Research output: Contribution to journalArticle

Drug Carriers
Hydrogels
Graphite
Acrylamide
Doxorubicin
10 Citations (Scopus)

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In : Cytotechnology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Episodic Memory
Catechin
Memory Disorders
Cytotoxicity
Doxorubicin
1 Citation (Scopus)

Chemically characterised extract of Saraca asoca improves the sexual function in male Wistar rats

Gill, M., Rai, A., Kinra, M., Sumalatha, S., Rao, C. M., Cheruku, S. P., Devkar, R. & Kumar, N., 01-09-2018, In : Andrologia. 50, 7, e13037.

Research output: Contribution to journalArticle

Wistar Rats
Sexual Behavior
Spermatozoa
Aphrodisiacs
Sperm Count
3 Citations (Scopus)

Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model

Gill, M., Kinra, M., Rai, A., Chamallamudi, M. R. & Kumar, N., 01-01-2018, In : NeuroReport. 29, 2, p. 134-140 7 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Antioxidants
Sucrose
Brain
Plant Bark
4 Citations (Scopus)

Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In : Journal of Ethnopharmacology. 210, p. 118-124 7 p.

Research output: Contribution to journalArticle

Tamarindus
Aphrodisiacs
Saponins
Phenol
Arousal

Modulatory role of mucuna pruriens against aluminium fluoride induced neuronal and behavioural alterations in rats

Nayak, V. S., Kumar, N., Dsouza, A. S., Nayak, S. S. & Pai, K. S. R., 01-04-2018, In : Journal of Clinical and Diagnostic Research. 12, 4, p. FC01-FC04

Research output: Contribution to journalArticle

Mucuna
Oxidative stress
Rats
Oxidative Stress
Quercetin
Terminalia
Liver Diseases
Ethanol
Poisons
Liver
2017

Decitabine nanoparticles supplement docetaxel in the treatment of non-small cell lung cancer (NSCLC)

Jain, P., Kumar, N., Tiwari, M., Rao, J. V. & Udupa, N., 01-03-2017, In : Advanced Science Letters. 23, 3, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

decitabine
docetaxel
Lung Cancer
Non-Small Cell Lung Carcinoma
Nanoparticles
8 Citations (Scopus)

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-05-2017, In : NeuroReport. 28, 9, p. 540-544 5 p.

Research output: Contribution to journalArticle

Dementia
Insulin
Rivastigmine
Frontal Lobe
Glucose
1 Citation (Scopus)

Evaluation of hepatoprotective effect of aqueous extract of Schrebera swietenioides bark against carbon tetrachloride-induced toxicity in wistar rats

Kumar, N., Choudhary, A., Tiwari, A., Rasal, A., Jetti, R. & Mallikarjuna Rao, C., 01-03-2017, In : Advanced Science Letters. 23, 3, p. 1917-1920 4 p.

Research output: Contribution to journalArticle

Carbon tetrachloride
Carbon Tetrachloride
Toxicants
Toxicity
Liver

Evaluation of in vitro and in vivo anticancer potential of two 5-acetamido chalcones against breast cancer

Wankhede, S., Kumar, N., Simon, L., Biswas, S., Gourishetti, K., Ramalingayya, G. V., Joshi, M. & Rao, C. M., 19-10-2017, In : EXCLI Journal. 16, p. 1150-1163 14 p.

Research output: Contribution to journalArticle

Chalcones
chalcones
Tumor Burden
breast neoplasms
Breast Neoplasms
4 Citations (Scopus)
Oxidative stress
Episodic Memory
Doxorubicin
Wistar Rats
Rats
6 Citations (Scopus)
Chalcone
chalcone
Cell Cycle Checkpoints
colorectal neoplasms
Colonic Neoplasms

Long-term exposure to a butter-rich diet induces mild-to-moderate steatosis in Chang liver cells and Swiss albino mice models

Nalloor, T. J. P., Kumar, N., Narayanan, K. & Palanimuthu, V. R., 01-05-2017, In : Journal of Basic and Clinical Physiology and Pharmacology. 28, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Butter
Diet
Liver
Phosphoric Monoester Hydrolases
Fats
2 Citations (Scopus)

The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia

Nayak, V. S., Kumar, N., D'Souza, A. S., Nayak, S. S., Cheruku, S. P. & Pai, K. S. R., 01-01-2017, In : NeuroReport. 28, 18, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

Mucuna
Ischemia
Brain Ischemia
Brain
Carotid Arteries
2016
9 Citations (Scopus)

An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells

Reddy, N. D., Shoja, M. H., Biswas, S., Nayak, P. G., Kumar, N. & Rao, C. M., 25-06-2016, In : Chemico-Biological Interactions. 253, p. 112-124 13 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Sulfonamides
Human Activities
Cells
Histone Deacetylases

Decitabine nanoparticles and docetaxel combination shrinks mammary carcinoma induced by DMBA in female sprague-dawley rats

Jain, P., Kumar, N., Tiwari, M., Rao, J. V., Shilpee, C. & Udupa, N., 01-10-2016, In : International Journal of Toxicological and Pharmacological Research. 8, 5, p. 397-405 9 p.

Research output: Contribution to journalArticle

decitabine
docetaxel
9,10-Dimethyl-1,2-benzanthracene
Nanoparticles
Sprague Dawley Rats
2 Citations (Scopus)
Ceiba
Cytotoxicity
Ascites
Tumors
Cells
5 Citations (Scopus)
Caesalpinia
Liver Cirrhosis
Liver
Silymarin
Control Groups

In vitro and in vivo hepatoprotective action of L-α-phosphatidylcholine in alcohol-induced toxicity model

Raj, P. V., Mudgal, J., Reddy, N. D., Rao, C. M., Bansal, P., Rai, A. & Kumar, N., 01-11-2016, In : International Journal of Pharmaceutical Sciences Review and Research. 41, 1, p. 171-176 6 p., 33.

Research output: Contribution to journalArticle

Phosphatidylcholines
Silymarin
Alcohols
Sulfhydryl Compounds
Wistar Rats
2 Citations (Scopus)

In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells

Mudgal, J., Shetty, P., Reddy, N. D., Akhila, H. S., Gourishetti, K., Mathew, G., Nayak, P. G., Kumar, N., Kishore, A., Kutty, N. G., Nandakumar, K., Shenoy, R. R., Rao, C. M. & Joseph, A., 14-10-2016, In : Frontiers in Pharmacology. 7, OCT, 381.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Sucrose
Diet
Phosphorylation
2 Citations (Scopus)
decitabine
K562 Cells
S Phase
Nanoparticles
Oral Administration
3 Citations (Scopus)
2 Citations (Scopus)
Arthritis
Experimental Arthritis
Cytokines
Dinoprostone
Stomach
4 Citations (Scopus)

Selected novel 5’-amino-2’-hydroxy-1, 3-diaryl-2- propen-1-ones arrest cell cycle of HCT-116 in G0/G1 phase

Simon, L., Srinivasan, K. K., Kumar, N., Reddy, N. D., Biswas, S., Mallikarjuna Rao, C. & Moorkoth, S., 13-01-2016, In : EXCLI Journal. 15, p. 21-32 12 p.

Research output: Contribution to journalArticle

HCT116 Cells
Cell Cycle Resting Phase
G1 Phase
Cell Cycle Checkpoints
interphase
3 Citations (Scopus)

Standardised extract of safed musli (Chlorophytum borivilianum) increases aphrodisiac potential besides being safe in male Wistar rats

Das, S., Singhal, S., Kumar, N., Rao, C. M., Sumalatha, S., Dave, J., Dave, R. & Nandakumar, K., 01-12-2016, In : Andrologia. 48, 10, p. 1236-1243 8 p.

Research output: Contribution to journalArticle

Aphrodisiacs
Wistar Rats
Oligospermia
Glass
Safety
3 Citations (Scopus)

Synthesis and evaluation of selected 1,3,4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity

Tiwari, A., Gopalan Kutty, N., Kumar, N., Chaudhary, A., Vasanth Raj, P., Shenoy, R. & Mallikarjuna Rao, C., 01-12-2016, In : Cytotechnology. 68, 6, p. 2553-2565 13 p.

Research output: Contribution to journalArticle

Amikacin
Cytotoxicity
Tumors
Cells
Derivatives
2015
17 Citations (Scopus)

In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma

Reddy, N. D., Shoja, M. H., Jayashree, B. S., Nayak, P. G., Kumar, N., Prasad, V. G., Pai, K. S. R. & Rao, C. M., 25-05-2015, In : Chemico-Biological Interactions. 233, p. 81-94 14 p.

Research output: Contribution to journalArticle

Sulfonamides
Caspase 7
Colon
Adenocarcinoma
Annexin A5
30 Citations (Scopus)
Simvastatin
Frontal Lobe
Aluminum
Hippocampus
Rivastigmine
4 Citations (Scopus)

Novel 2,5-disubstituted-1,3,4-oxadiazole derivatives induce apoptosis in HepG2 cells through p53 mediated intrinsic pathway

Sankhe, N. M., Durgashivaprasad, E., Gopalan Kutty, N., Venkata Rao, J., Narayanan, K., Kumar, N., Jain, P., Udupa, N. & Vasanth Raj, P., 31-07-2015, (Accepted/In press) In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

Cell death
Cells
Apoptosis
Derivatives
DNA
21 Citations (Scopus)

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats

John, J., Nampoothiri, M., Kumar, N., Mudgal, J., Nampurath, G. K. & Chamallamudi, M. R., 01-04-2015, In : Pharmacognosy Magazine. 11, 42, p. 327-336 10 p.

Research output: Contribution to journalArticle

Lipids
Frontal Lobe
Hippocampus
Sesame Oil
Rivastigmine
2 Citations (Scopus)

Subacute toxicity study of lacidipine nanoformulation

Shirodkar, R., Reddy, N., Kumar, N., Ramalingayya, G., Mutalik, S. & Lewis, S., 26-09-2015, In : Latin American Journal of Pharmacy. 34, 8, p. 1526-1533 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Lipids
Body Weight
Drug Compounding
Wistar Rats
11 Citations (Scopus)

Targets in anticancer research-a review

Jayashree, B. S., Nigam, S., Pai, A., Patel, H. K., Reddy, N. D., Kumar, N. & Rao, C. M., 01-08-2015, In : Indian Journal of Experimental Biology. 53, 8, p. 489-507 19 p.

Research output: Contribution to journalArticle

Research
Pharmaceutical Preparations
Clinical Trials
Neoplasms
Histone Deacetylases
2014
6 Citations (Scopus)

Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents

Kumar, N., Dhayabaran, D., Nampoothiri, M., Nandakumar, K., Puratchikody, A., Lalani, N., Dawood, K. & Ghosh, A., 01-10-2014, In : Korean Journal of Physiology and Pharmacology. 18, 5, p. 365-369 5 p.

Research output: Contribution to journalArticle

Cedrus
Second-Generation Antidepressive Agents
Hindlimb Suspension
Rodentia
Serotonin
3 Citations (Scopus)

Hepatoprotective role of Caesalpenia bonduc: A histopathological and biochemical study

Sumalatha, S., Pai, K. S. R., Kumar, N. & Bhat, K. M. R., 20-11-2014, In : Journal of Clinical and Diagnostic Research. 8, 11, p. HF05-HF07

Research output: Contribution to journalArticle

Rats
Medicine
Animals
Blood
Carbon Tetrachloride
26 Citations (Scopus)

Insulin blocks glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells

Nampoothiri, M., Reddy, N. D., John, J., Kumar, N., Kutty Nampurath, G. & Rao Chamallamudi, M., 2014, In : Behavioural Neurology. 2014, 674164.

Research output: Contribution to journalArticle

Glutamic Acid
Insulin
Reactive Oxygen Species
Acridine Orange
Ethidium
15 Citations (Scopus)

Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer

Kumar, N., Dhamija, I., Vasanth Raj, P., Jayashree, B. S., Parihar, V., Manjula, S. N., Thomas, S., Gopalan Kutty, N. & Mallikarjuna Rao, C., 2014, In : Arabian Journal of Chemistry. 7, 4, p. 409-417 9 p.

Research output: Contribution to journalArticle

Tumors
Derivatives
Liquids
Cytotoxicity
Transferases
43 Citations (Scopus)

Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells

Kumar, N., Rai, A., Reddy, N. D., Raj, P. V., Jain, P., Deshpande, P., Mathew, G., Kutty, N. G., Udupa, N. & Rao, C. M., 2014, In : Pharmacological Reports. 66, 5, p. 788-798 11 p.

Research output: Contribution to journalArticle

Silymarin
Liposomes
Biological Availability
Hepatocytes
Acetaminophen
2013
16 Citations (Scopus)
Catechin
Caspases
Hep G2 Cells
Liposomes
Biological Availability
37 Citations (Scopus)

Impact of caffeic acid on aluminium chloride-induced dementia in rats

Khan, K. A., Kumar, N., Nayak, P. G., Nampoothiri, M., Shenoy, R. R., Krishnadas, N., Rao, C. M. & Mudgal, J., 12-2013, In : Journal of Pharmacy and Pharmacology. 65, 12, p. 1745-1752 8 p.

Research output: Contribution to journalArticle

Dementia
Brain
Acetylcholinesterase
Nitrites
Glutathione Transferase
33 Citations (Scopus)
Cytotoxicity
Ascites
Tumors
Assays
Lymphoma
20 Citations (Scopus)

Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia

Kumar, N., Mudgal, J., Parihar, V. K., Nayak, P. G., Kutty, N. G. & Rao, C. M., 06-2013, In : Lipids. 48, 6, p. 633-638 6 p.

Research output: Contribution to journalArticle

Hyperlipidemias
Triglycerides
Cholesterol
Plasmas
Nutrition
13 Citations (Scopus)
Terminalia
Toxicology
Rodentia
Liver
Wounds and Injuries
2012
31 Citations (Scopus)

Elucidation of Structure-activity Relationship of 2-Quinolone Derivatives and Exploration of Their Antitumor Potential Through Bax-induced Apoptotic Pathway

Kumar, N., Raj, V. P., Jayshree, B. S., Kar, S. S., Anandam, A., Thomas, S., Jain, P., Rai, A. & Rao, C. M., 08-2012, In : Chemical Biology and Drug Design. 80, 2, p. 291-299 9 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cells
Derivatives
Ascites
Assays
2011
7 Citations (Scopus)

Effect of lecithin on d-galactosamine induced hepatotoxicity through mitochondrial pathway involving Bcl-2 and Bax

Raj, P. V., Nitesh, K., Prateek, J., Sankhe, M. N., Rao, J. V., Rao, C. M. & Udupa, N., 10-2011, In : Indian Journal of Clinical Biochemistry. 26, 4, p. 378-384 7 p.

Research output: Contribution to journalArticle

Galactosamine
Lecithins
Liver
Rats
Messenger RNA
2010
23 Citations (Scopus)

Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract

Manjula, S. N., Kenganora, M., Parihar, V. K., Kumar, S., Nayak, P. G., Kumar, N., Ranganath Pai, K. S. & Rao, C. M., 2010, In : Pharmaceutical Biology. 48, 6, p. 690-696 7 p.

Research output: Contribution to journalArticle

Polyalthia
Ascites
Ethanol
Antioxidants
Inhibitory Concentration 50