Krishnadas Nandakumar

BPharm, MPharm (Pharmacology), PhD, Professor

  • MCOPS Building, Karnataka Sate, Udupi District

    576104 Manipal

    India

  • 575 Citations
  • 12 h-Index
20032019
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Research Output 2003 2019

  • 575 Citations
  • 12 h-Index
  • 82 Article
  • 3 Letter
  • 3 Review article
2019
2 Citations (Scopus)

Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In : Biomedical Reports. 11, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Catechin
Sprague Dawley Rats
Rats
Oxidative Stress

Medhya rasayana restores memory function against doxorubicin-induced cognitive decline: Possibly by its neuroprotective effect

Gourishetti, K., Ghetia, S., Jacob, L., Mallik, S. B., Nayak, P. G., Kishore, A., Nandakumar, K., Alnaseer, S. M. & Hussain, S. M., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S104-S111

Research output: Contribution to journalArticle

Open Access
Neuroprotective Agents
Doxorubicin
G2 Phase
Cell Division
Therapeutics

Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In : Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Rutin
Doxorubicin
Rats
Breast Neoplasms
2 Citations (Scopus)

Sesamol and health - A comprehensive review

Shah, A., Lobo, R., Krishnadas, N. & Surubhotla, R., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S28-S42

Research output: Contribution to journalReview article

Open Access
Health
Anti-Inflammatory Agents
Antioxidants
Skin
sesamol
2018
3 Citations (Scopus)
Quinolinic Acid
Corpus Striatum
Huntington Disease
Lipid Peroxidation
Brain
14 Citations (Scopus)

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In : Cytotechnology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Episodic Memory
Catechin
Memory Disorders
Cytotoxicity
Doxorubicin
Sodium Glutamate
Nutrition
Medical problems
Type 2 Diabetes Mellitus
Blood Vessels
5 Citations (Scopus)

Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In : Journal of Ethnopharmacology. 210, p. 118-124 7 p.

Research output: Contribution to journalArticle

Tamarindus
Aphrodisiacs
Saponins
Phenol
Arousal
8 Citations (Scopus)

Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In : International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

Research output: Contribution to journalArticle

Chitosan
Nanoparticles
Pharmacodynamics
Pharmacokinetics
Pharmaceutical Preparations
2 Citations (Scopus)

Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In : Pharmacognosy Magazine. 14, 55, p. S197-S207

Research output: Contribution to journalArticle

Doxorubicin
Episodic Memory
Locomotion
Reactive Oxygen Species
Flow Cytometry
1 Citation (Scopus)
5-alpha Reductase Inhibitors
Quantitative Structure-Activity Relationship
Dihydrotestosterone
Oxidoreductases
Ligands
1 Citation (Scopus)

Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells

Kumar, N., Shrungeswara, A. H., Mallik, S. B., Biswas, S., Mathew, J., Nandakumar, K., Mathew, J. & Lobo, R., 01-01-2018, In : Anti-cancer agents in medicinal chemistry. 18, 11, p. 1563-1572 10 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Protein Kinases
Apoptosis
Hepatocellular Carcinoma
Phytochemicals
5 Citations (Scopus)

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Verma, M. K., Goel, R., Krishnadas, N. & Nemmani, K. V. S., 03-07-2018, In : Expert Opinion on Therapeutic Targets. 22, 7, p. 615-628 14 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Cerebrovascular Disorders
Glucose
Peptides
Neurology
2017
7 Citations (Scopus)

Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

Verma, M. K., Goel, R., Nandakumar, K. & Nemmani, K. V. S., 05-06-2017, In : European Journal of Pharmacology. 804, p. 38-45 8 p.

Research output: Contribution to journalArticle

Dopamine
Corpus Striatum
Parkinson Disease
Brain
Gastric Inhibitory Polypeptide
8 Citations (Scopus)

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-05-2017, In : NeuroReport. 28, 9, p. 540-544 5 p.

Research output: Contribution to journalArticle

Dementia
Insulin
Rivastigmine
Frontal Lobe
Glucose
2 Citations (Scopus)
Dementia
Rats
Insulin
Data storage equipment
Glucose
4 Citations (Scopus)
Oxidative stress
Episodic Memory
Doxorubicin
Wistar Rats
Rats
4 Citations (Scopus)

Pinocembrin enriched fraction of Elytranthe parasitica (L.) Danser induces apoptosis in HCT 116 colorectal cancer cells

Kumar, N., Biswas, S., Hosur Shrungeswara, A., Basu Mallik, S., Hipolith Viji, M., Elizabeth Mathew, J., Mathew, J., Nandakumar, K. & Lobo, R., 01-06-2017, In : Journal of Infection and Chemotherapy. 23, 6, p. 354-359 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Phytochemicals
Apoptosis
Cell Cycle Checkpoints
Gas Chromatography-Mass Spectrometry
18 Citations (Scopus)

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya, G. V., Cheruku, S. P., Nayak, P. G., Kishore, A., Shenoy, R., Rao, M. & Krishnadas, N., 29-03-2017, In : Drug Design, Development and Therapy. 11, p. 1011-1026 16 p.

Research output: Contribution to journalArticle

Rutin
Memory Disorders
Doxorubicin
Wistar Rats
Neurites
3 Citations (Scopus)

Sodium valproate enhances doxorubicin-induced cognitive dysfunction in Wistar rats

Verma, T., Mallik, S. B., Ramalingayya, G. V., Nayak, P. G., Kishore, A., Pai, K. S. R. & Nandakumar, K., 01-12-2017, In : Biomedicine and Pharmacotherapy. 96, p. 736-741 6 p.

Research output: Contribution to journalArticle

Valproic Acid
Histone Deacetylases
Doxorubicin
Wistar Rats
Antioxidants
2016
1 Citation (Scopus)
Acetone
Cells
Cell Line
Klebsiella pneumoniae
Cytotoxicity
8 Citations (Scopus)

Assessment of female rats for studying episodic memory and its deficit associated with doxorubicin-induced chemobrain

Ramalingayya, G. V., Gourishetti, K., Kishore, A. & Nandakumar, K., 01-06-2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 6, p. 644-646 3 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome

Karot, S. S., Surenahalli, V. G., Kishore, A., Mudgal, J., Nandakumar, K., Chirayil, M. T., Mathew, G. & Nampurath, G. K., 01-09-2016, In : Journal of Diabetes. 8, 5, p. 629-639 11 p.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Rodentia
Interleukin-6
Reactive Oxygen Species
Nitric Oxide
Phenylephrine
Muscarinic Receptors
Thoracic Aorta
Vasodilator Agents
Vasodilation

Evaluation of antidiarrhoeal effect of acetone extract fraction from the stem bark of T. Populnea

Florance, E. J., Dhayabaran, D. & Nandakumar, K., 01-06-2016, In : International Journal of Pharmacognosy and Phytochemical Research. 8, 6, p. 956-959 4 p.

Research output: Contribution to journalArticle

Antidiarrheals
Acetone
Diarrhea
Castor Oil
Charcoal
2 Citations (Scopus)
2 Citations (Scopus)

In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells

Mudgal, J., Shetty, P., Reddy, N. D., Akhila, H. S., Gourishetti, K., Mathew, G., Nayak, P. G., Kumar, N., Kishore, A., Kutty, N. G., Nandakumar, K., Shenoy, R. R., Rao, C. M. & Joseph, A., 14-10-2016, In : Frontiers in Pharmacology. 7, OCT, 381.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Sucrose
Diet
Phosphorylation
Geriatrics
Tertiary Healthcare
Teaching Hospitals
Teaching
Prospective Studies
24 Citations (Scopus)
Rutin
Episodic Memory
Memory Disorders
Scopolamine Hydrobromide
Long-Term Memory
6 Citations (Scopus)
Hepatocellular Carcinoma
Loranthaceae
Ether
Gallic Acid
Acridine Orange
5 Citations (Scopus)

Sambar, an Indian Dish Prevents the Development of Dimethyl Hydrazine-Induced Colon Cancer: A Preclinical Study

Prasad, V. G., Reddy, N., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, M. C. & Shenoy, R., 07-2016, In : Pharmacognosy Magazine. 12, 47, p. S441-S445

Research output: Contribution to journalArticle

hydrazine
1,2-Dimethylhydrazine
Colonic Neoplasms
Aberrant Crypt Foci
Spices
4 Citations (Scopus)

Standardised extract of safed musli (Chlorophytum borivilianum) increases aphrodisiac potential besides being safe in male Wistar rats

Das, S., Singhal, S., Kumar, N., Rao, C. M., Sumalatha, S., Dave, J., Dave, R. & Nandakumar, K., 01-12-2016, In : Andrologia. 48, 10, p. 1236-1243 8 p.

Research output: Contribution to journalArticle

Aphrodisiacs
Wistar Rats
Oligospermia
Glass
Safety
2 Citations (Scopus)
Tertiary Care Centers
Urinary Tract Infections
India
Pharmaceutical Services
Prospective Studies
2014
5 Citations (Scopus)

Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara

Dhayabaran, D., Florance, E. J., Nandakumar, K., Shanmugarathinam, A. & Puratchikody, A., 2014, In : Journal of Natural Medicines. 68, 2, p. 310-315 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents

Kumar, N., Dhayabaran, D., Nampoothiri, M., Nandakumar, K., Puratchikody, A., Lalani, N., Dawood, K. & Ghosh, A., 01-10-2014, In : Korean Journal of Physiology and Pharmacology. 18, 5, p. 365-369 5 p.

Research output: Contribution to journalArticle

Cedrus
Second-Generation Antidepressive Agents
Hindlimb Suspension
Rodentia
Serotonin
5 Citations (Scopus)

Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer

Prasad, V. G., Kawade, S., Jayashree, B. S., Reddy, N. D., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, C. M. & Shenoy, R. R., 2014, In : BioMed Research International. 2014, 569130.

Research output: Contribution to journalArticle

Dimenhydrinate
Aberrant Crypt Foci
1,2-Dimethylhydrazine
Colonic Neoplasms
Cells
5 Citations (Scopus)

Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis

Patel, A., Biswas, S., Shoja, M. H., Ramalingayya, G. V. & Nandakumar, K., 2014, In : The Scientific World Journal. 2014, p. 345939

Research output: Contribution to journalArticle

Solanum nigrum
Chemoradiotherapy
Stomatitis
Chemotherapy
chemotherapy
2013
3 Citations (Scopus)

A rat model against chemotherapy plus radiation-induced oral mucositis

Patel, A., Rajesh, S., Chandrashekhar, V. M., Rathnam, S., Shah, K., Mallikarjuna Rao, C. & Nandakumar, K., 10-2013, In : Saudi Pharmaceutical Journal. 21, 4, p. 399-403 5 p.

Research output: Contribution to journalArticle

Stomatitis
Radiation
Mucositis
Drug Therapy
Tongue
3 Citations (Scopus)

Evaluation of in vitro antioxidant and in Vivo analgesic potential of Terminalia paniculata aqueous bark extract

Talwar, S., Nayak, P. G., Mudgal, J., Paul, P., Bansal, P. & Nandakumar, K., 2013, In : Journal of Medicinal Food. 16, 12, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats

Debnath, T., Radhakrishnan, R., Gopal, M., Talwar, S. & Nandakumar, K., 2013, In : Pakistan Journal of Pharmaceutical Sciences. 26, 4, p. 673-679 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Impact of caffeic acid on aluminium chloride-induced dementia in rats

Khan, K. A., Kumar, N., Nayak, P. G., Nampoothiri, M., Shenoy, R. R., Krishnadas, N., Rao, C. M. & Mudgal, J., 12-2013, In : Journal of Pharmacy and Pharmacology. 65, 12, p. 1745-1752 8 p.

Research output: Contribution to journalArticle

Dementia
Brain
Acetylcholinesterase
Nitrites
Glutathione Transferase
13 Citations (Scopus)
Terminalia
Toxicology
Rodentia
Liver
Wounds and Injuries
2012
1 Citation (Scopus)

Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum

Dhayabaran, D., Florance, J., Krsihnadas, N., [Unknown], I. & Varma, M., 2012, In : Brazilian Journal of Pharmacognosy. 22, 3, p. 623-629 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Isolation and anxiolytic activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione from the ethanolic extract of heart wood of Cedrus deodara

Dhayabaran, D., Florance, J., Nandakumar, K. & Puratchikody, A., 2012, In : Medicinal Chemistry Research. 21, 11, p. 3460-3464 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones

Viswanatha, G. L., Priyadarshini, B. J., Krishnadas, N., Janardhanan, S., Rangappa, S. & Hanumanthappa, S., 2012, In : Saudi Pharmaceutical Journal. 20, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

2011
7 Citations (Scopus)

Analgesic, anti-inflammatory and antiarthritic activity of newly synthesized bicyclothieno 1, 2, 3 - triazines

Viswanatha, G. L., Akinapally, N., Shylaja, H., Nandakumar, K., Srinath, R. & Janardhanan, S., 2011, In : Macedonian Journal of Medical Sciences. 4, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents: Possible antimotility and antisecretory mechanisms

Viswanatha, G. L. S., Hanumanthappa, S., Krishnadas, N. & Rangappa, S., 2011, In : Asian Pacific Journal of Tropical Medicine. 4, 6, p. 451-456 6 p.

Research output: Contribution to journalArticle

Antidiarrhoeal activity of leaf extracts of Tylophora indica (Asclepiadaceae) in rodents

Patel, N. J., Gujarati, V. B., Gouda, T. S., Venkat Rao, N. & Nandakumar, K., 2011, In : Pharmacologyonline. 2, p. 586-596 11 p.

Research output: Contribution to journalArticle