Krishnadas Nandakumar

2019

Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In : Biomedical Reports. 11, 2, p. 79-84 6 p.

Research output: Contribution to journal › Article

Open Access

Oxidative stress

Catechin

Sprague Dawley Rats

Rats

Oxidative Stress

Medhya rasayana restores memory function against doxorubicin-induced cognitive decline: Possibly by its neuroprotective effect

Gourishetti, K., Ghetia, S., Jacob, L., Mallik, S. B., Nayak, P. G., Kishore, A., Nandakumar, K., Alnaseer, S. M. & Hussain, S. M., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S104-S111

Research output: Contribution to journal › Article

Open Access

Neuroprotective Agents

Doxorubicin

G2 Phase

Cell Division

Therapeutics

Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In : Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

Research output: Contribution to journal › Article

Methylnitrosourea

Rutin

Doxorubicin

Rats

Breast Neoplasms

2 Citations (Scopus)

Sesamol and health - A comprehensive review

Shah, A., Lobo, R., Krishnadas, N. & Surubhotla, R., 01-04-2019, In : Indian Journal of Pharmaceutical Education and Research. 53, 2, p. S28-S42

Research output: Contribution to journal › Review article

Open Access

Health

Anti-Inflammatory Agents

Antioxidants

Skin

sesamol

2018

3 Citations (Scopus)

Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala²GIP in rat model of Huntington's disease

Verma, M. K., Goel, R., Nandakumar, K. & Nemmani, K. V. S., 05-06-2018, In : European Journal of Pharmacology. 828, p. 31-41 11 p.

Research output: Contribution to journal › Article

Quinolinic Acid

Corpus Striatum

Huntington Disease

Lipid Peroxidation

Brain

Catechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of wistar rats

Saimithra, T., Kumar, N., Nandakumar, K., Nampoothiri, M. & Rao, C. M., 01-05-2018, In : Indian Journal of Experimental Biology. 56, 5, p. 314-321 8 p.

Research output: Contribution to journal › Article

Cachexia

Catechin

Tea

Dexamethasone

Acetylcholine

14 Citations (Scopus)

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In : Cytotechnology. p. 1-15 15 p.

Research output: Contribution to journal › Article

Episodic Memory

Catechin

Memory Disorders

Cytotoxicity

Doxorubicin

Combined administration of monosodium glutamate and high sucrose diet accelerates the induction of type 2 diabetes, vascular dysfunction, and memory impairment in rats

Saikrishna, K., Kumari, R., Chaitanya, K., Biswas, S., Nayak, P. G., Mudgal, J., Kishore, A. & Nandakumar, K., 01-01-2018, In : Journal of Environmental Pathology, Toxicology and Oncology. 37, 1, p. 63-80 18 p.

Research output: Contribution to journal › Article

Sodium Glutamate

Nutrition

Medical problems

Type 2 Diabetes Mellitus

Blood Vessels

5 Citations (Scopus)

Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In : Journal of Ethnopharmacology. 210, p. 118-124 7 p.

Research output: Contribution to journal › Article

Tamarindus

Aphrodisiacs

Saponins

Phenol

Arousal

8 Citations (Scopus)

Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In : International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

Research output: Contribution to journal › Article

Chitosan

Nanoparticles

Pharmacodynamics

Pharmacokinetics

Pharmaceutical Preparations

2 Citations (Scopus)

Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In : Pharmacognosy Magazine. 14, 55, p. S197-S207

Research output: Contribution to journal › Article

Doxorubicin

Episodic Memory

Locomotion

Reactive Oxygen Species

Flow Cytometry

1 Citation (Scopus)

Pharmacophore and atom based 3D QSAR studies on the novel 5-alpha-reductase inhibitors

Shah, A., Lobo, R., Krishnadas, N. & Pai, A., 01-10-2018, In : Indian Journal of Pharmaceutical Education and Research. 52, 4, p. S296-S302

Research output: Contribution to journal › Article

5-alpha Reductase Inhibitors

Quantitative Structure-Activity Relationship

Dihydrotestosterone

Oxidoreductases

Ligands

1 Citation (Scopus)

Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells

Kumar, N., Shrungeswara, A. H., Mallik, S. B., Biswas, S., Mathew, J., Nandakumar, K., Mathew, J. & Lobo, R., 01-01-2018, In : Anti-cancer agents in medicinal chemistry. 18, 11, p. 1563-1572 10 p.

Research output: Contribution to journal › Article

Hep G2 Cells

Protein Kinases

Apoptosis

Hepatocellular Carcinoma

Phytochemicals

5 Citations (Scopus)

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Verma, M. K., Goel, R., Krishnadas, N. & Nemmani, K. V. S., 03-07-2018, In : Expert Opinion on Therapeutic Targets. 22, 7, p. 615-628 14 p.

Research output: Contribution to journal › Review article

Neurodegenerative Diseases

Cerebrovascular Disorders

Glucose

Peptides

Neurology

2017

7 Citations (Scopus)

Effect of D-Ala²GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

Verma, M. K., Goel, R., Nandakumar, K. & Nemmani, K. V. S., 05-06-2017, In : European Journal of Pharmacology. 804, p. 38-45 8 p.

Research output: Contribution to journal › Article

Dopamine

Corpus Striatum

Parkinson Disease

Brain

Gastric Inhibitory Polypeptide

8 Citations (Scopus)

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-05-2017, In : NeuroReport. 28, 9, p. 540-544 5 p.

Research output: Contribution to journal › Article

Dementia

Insulin

Rivastigmine

Frontal Lobe

Glucose

2 Citations (Scopus)

Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats

Nampoothiri, M., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-01-2017, In : Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 36, 2, p. 159-169 11 p.

Research output: Contribution to journal › Article

Dementia

Rats

Insulin

Data storage equipment

Glucose

4 Citations (Scopus)

Insulin protects against brain oxidative stress with an apparent effect on episodic memory in doxorubicin-induced cognitive dysfunction in wistar rats

Ramalingayya, G. V., Sonawane, V., Cheruku, S. P., Kishore, A., Nayak, P. G., Kumar, N., Shenoy, R. R. & Nandakumar, K., 2017, In : Journal of Environmental Pathology, Toxicology and Oncology. 36, 2, p. 121-130 10 p.

Research output: Contribution to journal › Article

Oxidative stress

Episodic Memory

Doxorubicin

Wistar Rats

Rats

4 Citations (Scopus)

Pinocembrin enriched fraction of Elytranthe parasitica (L.) Danser induces apoptosis in HCT 116 colorectal cancer cells

Kumar, N., Biswas, S., Hosur Shrungeswara, A., Basu Mallik, S., Hipolith Viji, M., Elizabeth Mathew, J., Mathew, J., Nandakumar, K. & Lobo, R., 01-06-2017, In : Journal of Infection and Chemotherapy. 23, 6, p. 354-359 6 p.

Research output: Contribution to journal › Article

Colorectal Neoplasms

Phytochemicals

Apoptosis

Cell Cycle Checkpoints

Gas Chromatography-Mass Spectrometry

18 Citations (Scopus)

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya, G. V., Cheruku, S. P., Nayak, P. G., Kishore, A., Shenoy, R., Rao, M. & Krishnadas, N., 29-03-2017, In : Drug Design, Development and Therapy. 11, p. 1011-1026 16 p.

Research output: Contribution to journal › Article

Rutin

Memory Disorders

Doxorubicin

Wistar Rats

Neurites

3 Citations (Scopus)

Sodium valproate enhances doxorubicin-induced cognitive dysfunction in Wistar rats

Verma, T., Mallik, S. B., Ramalingayya, G. V., Nayak, P. G., Kishore, A., Pai, K. S. R. & Nandakumar, K., 01-12-2017, In : Biomedicine and Pharmacotherapy. 96, p. 736-741 6 p.

Research output: Contribution to journal › Article

Valproic Acid

Histone Deacetylases

Doxorubicin

Wistar Rats

Antioxidants

2016

1 Citation (Scopus)

Antimicrobial, anticancer and cytotoxic activities of acetone extract fraction from stem bark of Thespesia populnea (Linn.)

Jeyaseeli Florance, E., Dhayabaran, D. & Nandakumar, K., 2016, In : Research Journal of Pharmaceutical, Biological and Chemical Sciences. 7, 3, p. 1722-1728 7 p.

Research output: Contribution to journal › Article

Acetone

Cells

Cell Line

Klebsiella pneumoniae

Cytotoxicity

8 Citations (Scopus)

Assessment of female rats for studying episodic memory and its deficit associated with doxorubicin-induced chemobrain

Ramalingayya, G. V., Gourishetti, K., Kishore, A. & Nandakumar, K., 01-06-2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 6, p. 644-646 3 p.

Research output: Contribution to journal › Letter

1 Citation (Scopus)

Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome

Karot, S. S., Surenahalli, V. G., Kishore, A., Mudgal, J., Nandakumar, K., Chirayil, M. T., Mathew, G. & Nampurath, G. K., 01-09-2016, In : Journal of Diabetes. 8, 5, p. 629-639 11 p.

Research output: Contribution to journal › Article

Hypoglycemic Agents

Rodentia

Interleukin-6

Reactive Oxygen Species

Nitric Oxide

Endothelium dependent and independent mechanisms of vasorelaxant activity of synthesized 2,5-disubstituted-1,3,4-oxadiazole derivatives in rat thoracic aorta-ex vivo and molecular docking studies

Attari, Z., Mudgal, J., Nayak, P. G., Krishnadas, N., Rajappan, R. & Gopalan Kutty, N., 01-06-2016, In : Letters in Drug Design and Discovery. 13, 5, p. 441-450 10 p.

Research output: Contribution to journal › Article

Phenylephrine

Muscarinic Receptors

Thoracic Aorta

Vasodilator Agents

Vasodilation

Evaluation of antidiarrhoeal effect of acetone extract fraction from the stem bark of T. Populnea

Florance, E. J., Dhayabaran, D. & Nandakumar, K., 01-06-2016, In : International Journal of Pharmacognosy and Phytochemical Research. 8, 6, p. 956-959 4 p.

Research output: Contribution to journal › Article

Antidiarrheals

Acetone

Diarrhea

Castor Oil

Charcoal

2 Citations (Scopus)

Female rats induced with mammary cancer as a relevant animal model for doxorubicin-induced chemobrain in vivo

Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Rao, C. M. & Nandakumar, K., 01-09-2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 9, p. 862-863 2 p.

Research output: Contribution to journal › Letter

2 Citations (Scopus)

In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells

Mudgal, J., Shetty, P., Reddy, N. D., Akhila, H. S., Gourishetti, K., Mathew, G., Nayak, P. G., Kumar, N., Kishore, A., Kutty, N. G., Nandakumar, K., Shenoy, R. R., Rao, C. M. & Joseph, A., 14-10-2016, In : Frontiers in Pharmacology. 7, OCT, 381.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases

p38 Mitogen-Activated Protein Kinases

Sucrose

Diet

Phosphorylation

Monitoring of adverse reactions in geriatric south Indian patients in a tertiary care teaching hospital: A prospective study

Ramanath, K. V., Prabhu, M. M., Nandakumar, K. & Pai, K. S. R., 2016, In : Research Journal of Pharmaceutical, Biological and Chemical Sciences. 7, 1, p. 1381-1387 7 p.

Research output: Contribution to journal › Article

Geriatrics

Tertiary Healthcare

Teaching Hospitals

Teaching

Prospective Studies

24 Citations (Scopus)

Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks

Ramalingayya, G. V., Nampoothiri, M., Nayak, P. G., Kishore, A., Shenoy, R. R., Rao, C. M. & Nandakumar, K., 2016, In : Pharmacognosy Magazine. 12, 45, p. S63-S70

Research output: Contribution to journal › Article

Rutin

Episodic Memory

Memory Disorders

Scopolamine Hydrobromide

Long-Term Memory

6 Citations (Scopus)

Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 Hepatocellular carcinoma

Kumar, N., Biswas, S., Mathew, A. E., Varghese, S., Mathew, J. E., Nandakumar, K., Aranjani, J. M. & Lobo, R., 26-10-2016, In : BMC Complementary and Alternative Medicine. 16, 1, 420.

Research output: Contribution to journal › Article

Hepatocellular Carcinoma

Loranthaceae

Ether

Gallic Acid

Acridine Orange

5 Citations (Scopus)

Sambar, an Indian Dish Prevents the Development of Dimethyl Hydrazine-Induced Colon Cancer: A Preclinical Study

Prasad, V. G., Reddy, N., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, M. C. & Shenoy, R., 07-2016, In : Pharmacognosy Magazine. 12, 47, p. S441-S445

Research output: Contribution to journal › Article

hydrazine

1,2-Dimethylhydrazine

Colonic Neoplasms

Aberrant Crypt Foci

Spices

4 Citations (Scopus)

Standardised extract of safed musli (Chlorophytum borivilianum) increases aphrodisiac potential besides being safe in male Wistar rats

Das, S., Singhal, S., Kumar, N., Rao, C. M., Sumalatha, S., Dave, J., Dave, R. & Nandakumar, K., 01-12-2016, In : Andrologia. 48, 10, p. 1236-1243 8 p.

Research output: Contribution to journal › Article

Aphrodisiacs

Wistar Rats

Oligospermia

Glass

Safety

2 Citations (Scopus)

Urinary tract infection treatment pattern of elderly patients in a tertiary hospital setup in south India: A prospective study

Venkatesh, R. K., Prabhu, M. M., Nandakumar, K. & R Pai, K. S., 01-04-2016, In : Journal of Young Pharmacists. 8, 2, p. 108-113 6 p.

Research output: Contribution to journal › Article

Tertiary Care Centers

Urinary Tract Infections

India

Pharmaceutical Services

Prospective Studies

2014

5 Citations (Scopus)

Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara

Dhayabaran, D., Florance, E. J., Nandakumar, K., Shanmugarathinam, A. & Puratchikody, A., 2014, In : Journal of Natural Medicines. 68, 2, p. 310-315 6 p.

Research output: Contribution to journal › Article

6 Citations (Scopus)

Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents

Kumar, N., Dhayabaran, D., Nampoothiri, M., Nandakumar, K., Puratchikody, A., Lalani, N., Dawood, K. & Ghosh, A., 01-10-2014, In : Korean Journal of Physiology and Pharmacology. 18, 5, p. 365-369 5 p.

Research output: Contribution to journal › Article

Cedrus

Second-Generation Antidepressive Agents

Hindlimb Suspension

Rodentia

Serotonin

5 Citations (Scopus)

Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer

Prasad, V. G., Kawade, S., Jayashree, B. S., Reddy, N. D., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, C. M. & Shenoy, R. R., 2014, In : BioMed Research International. 2014, 569130.

Research output: Contribution to journal › Article

Dimenhydrinate

Aberrant Crypt Foci

1,2-Dimethylhydrazine

Colonic Neoplasms

Cells

5 Citations (Scopus)

Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis

Patel, A., Biswas, S., Shoja, M. H., Ramalingayya, G. V. & Nandakumar, K., 2014, In : The Scientific World Journal. 2014, p. 345939

Research output: Contribution to journal › Article

Solanum nigrum

Chemoradiotherapy

Stomatitis

Chemotherapy

chemotherapy

Reversal of Chronic Fatigue Induced Alterations by Sesamol in Mice: Evidence for Involvement of Oxidative Stress And Inflammatory Pathway

Nayak, P. G., Talwar, S., Bansal, P., Mudgal, J., Nandakumar, K. & Pai, K. S. R., 11-2014, In : Value in Health. 17, 7, p. A810

Research output: Contribution to journal › Article

2013

3 Citations (Scopus)

A rat model against chemotherapy plus radiation-induced oral mucositis

Patel, A., Rajesh, S., Chandrashekhar, V. M., Rathnam, S., Shah, K., Mallikarjuna Rao, C. & Nandakumar, K., 10-2013, In : Saudi Pharmaceutical Journal. 21, 4, p. 399-403 5 p.

Research output: Contribution to journal › Article

Stomatitis

Radiation

Mucositis

Drug Therapy

Tongue

3 Citations (Scopus)

Evaluation of in vitro antioxidant and in Vivo analgesic potential of Terminalia paniculata aqueous bark extract

Talwar, S., Nayak, P. G., Mudgal, J., Paul, P., Bansal, P. & Nandakumar, K., 2013, In : Journal of Medicinal Food. 16, 12, p. 1153-1161 9 p.

Research output: Contribution to journal › Article

4 Citations (Scopus)

Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats

Debnath, T., Radhakrishnan, R., Gopal, M., Talwar, S. & Nandakumar, K., 2013, In : Pakistan Journal of Pharmaceutical Sciences. 26, 4, p. 673-679 7 p.

Research output: Contribution to journal › Article

40 Citations (Scopus)

Impact of caffeic acid on aluminium chloride-induced dementia in rats

Khan, K. A., Kumar, N., Nayak, P. G., Nampoothiri, M., Shenoy, R. R., Krishnadas, N., Rao, C. M. & Mudgal, J., 12-2013, In : Journal of Pharmacy and Pharmacology. 65, 12, p. 1745-1752 8 p.

Research output: Contribution to journal › Article

Dementia

Brain

Acetylcholinesterase

Nitrites

Glutathione Transferase

13 Citations (Scopus)

Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents

Talwar, S., Jagani, H. V., Nayak, P. G., Kumar, N., Kishore, A., Bansal, P., Shenoy, R. R. & Nandakumar, K., 06-06-2013, In : BMC Complementary and Alternative Medicine. 13, 127.

Research output: Contribution to journal › Article

Terminalia

Toxicology

Rodentia

Liver

Wounds and Injuries

2012

1 Citation (Scopus)

Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum

Dhayabaran, D., Florance, J., Krsihnadas, N., [Unknown], I. & Varma, M., 2012, In : Brazilian Journal of Pharmacognosy. 22, 3, p. 623-629 7 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Isolation and anxiolytic activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione from the ethanolic extract of heart wood of Cedrus deodara

Dhayabaran, D., Florance, J., Nandakumar, K. & Puratchikody, A., 2012, In : Medicinal Chemistry Research. 21, 11, p. 3460-3464 5 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones

Viswanatha, G. L., Priyadarshini, B. J., Krishnadas, N., Janardhanan, S., Rangappa, S. & Hanumanthappa, S., 2012, In : Saudi Pharmaceutical Journal. 20, 1, p. 45-52 8 p.

Research output: Contribution to journal › Article

2011

7 Citations (Scopus)

Analgesic, anti-inflammatory and antiarthritic activity of newly synthesized bicyclothieno 1, 2, 3 - triazines

Viswanatha, G. L., Akinapally, N., Shylaja, H., Nandakumar, K., Srinath, R. & Janardhanan, S., 2011, In : Macedonian Journal of Medical Sciences. 4, 2, p. 131-138 8 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents: Possible antimotility and antisecretory mechanisms

Viswanatha, G. L. S., Hanumanthappa, S., Krishnadas, N. & Rangappa, S., 2011, In : Asian Pacific Journal of Tropical Medicine. 4, 6, p. 451-456 6 p.

Research output: Contribution to journal › Article

Antidiarrhoeal activity of leaf extracts of Tylophora indica (Asclepiadaceae) in rodents

Patel, N. J., Gujarati, V. B., Gouda, T. S., Venkat Rao, N. & Nandakumar, K., 2011, In : Pharmacologyonline. 2, p. 586-596 11 p.

Research output: Contribution to journal › Article