Raghu Chandrashekhar H

BPharm, MPharm (Pharmaceutical Biotechnology), PhD

Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal

https://orcid.org/0000-0002-6538-7758

Phone+91-820-2922482
Emailraghu.c@manipal.edu
Websitehttps://manipal.edu/mcops-manipal/department-faculty/faculty-list/raghu-chandrashekhara-h.html

Madhava Nagar, Manipal. Karnataka State, Pin - 576104.
India

Source: Scopus
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661 Citations
13 h-Index
43 Article
4 Review article
2 Conference contribution
2 Comment/debate
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43 results

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2021
A set of simple methods for detection and extraction of laminarinase
Koteshwara, A., Philip, N. V., Aranjani, J. M., Hariharapura, R. C. & Volety Mallikarjuna, S., 12-2021, In: Scientific Reports. 11, 1, 2489.
Research output: Contribution to journal › Article › peer-review

Open Access
2020
Statistical Optimization for Coproduction of Chitinase and Beta 1, 4-Endoglucanase by Chitinolytic Paenibacillus elgii PB1 Having Antifungal Activity
Philip, N. V., Koteshwara, A., Kiran, G. A., Raja, S., Subrahmanyam, V. M. & Chandrashekar, H. R., 01-05-2020, In: Applied Biochemistry and Biotechnology.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Steering of β oxidation intermediates to polyhydroxyalkanoate copolymer biosynthesis by fatty acids and inhibitors using Taguchi design
Madhusoodanan, G., Selvaraj, S., Kuthethur Sarvajna, S., Hariharapura, R. C. & Mysore Somashekhar, D., 01-05-2020, In: International Journal of Environmental Science and Technology. 17, 5, p. 2853-2864 12 p.
Research output: Contribution to journal › Article › peer-review
Strategic design of dicer substrate siRNA to mitigate the resistance mediated by ABCC1 in doxorubicinresistant breast cancer
Gatta, A. K., Chandrashekhar, R., Udupa, N., Reddy, M. S., Mutalik, S. & Josyula, V. R., 04-2020, In: Indian Journal of Pharmaceutical Sciences. 82, 2, p. 329-340 12 p.
Research output: Contribution to journal › Article › peer-review
The effects of recasting on the cytotoxicity of dental base metal casting alloys
Nandish, B., Jayaprakash, K., Shetty, H., Rao, S., Ginjupalli, K., Chandrashekhar, H. & Prabhu, S., 01-07-2020, In: Journal of Conservative Dentistry. 23, 4, p. 412-416 5 p.
Research output: Contribution to journal › Article › peer-review
2019
Improvement of the Production and Characterisation of Polyhydroxyalkanoate by Bacillus endophyticus Using Inexpensive Carbon Feedstock
Geethu, M., Vrundha, R., Raja, S., Raghu Chandrashekar, H. & Divyashree, M. S., 01-05-2019, In: Journal of Polymers and the Environment. 27, 5, p. 917-928 12 p.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Marine microbial metabolites as drug candidates for alzheimer’s disease
Muralidharan, A., Chandrasekhar, R. & Rao, J. V., 12-2019, In: Research Journal of Pharmacy and Technology. 12, 12, p. 6081-6086 6 p.
Research output: Contribution to journal › Article › peer-review
Novel isatin-indole derivatives as potential inhibitors of chorismate mutase (CM): Their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd-Cu catalysis
Reddy, G. S., Hossain, K. A., Kumar, J. S., Thirupataiah, B., Edwin, R. K., Giliyaru, V. B., Chandrashekhar Hariharapura, R., Shenoy, G. G., Misra, P. & Pal, M., 01-01-2019, In: RSC Advances. 10, 1, p. 289-297 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM)
Reddy, G. S., Snehalatha, A. V., Edwin, R. K., Hossain, K. A., Giliyaru, V. B., Hariharapura, R. C., Gautham Shenoy, G., Misra, P. & Pal, M., 01-10-2019, In: Bioorganic Chemistry. 91, 103155.
Research output: Contribution to journal › Article › peer-review
2018
Propargylamine (secondary) as a building block in indole synthesis involving ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method: Unexpected formation of (pyrazole)imine derivatives
Sujeevan Reddy, G., Babu Nallapati, S., Sri Saranya, P. S. V. K., Sridhar, B., Bhat Giliyaru, V., Chandrashekhar Hariharapura, R., Gautham Shenoy, G. & Pal, M., 26-12-2018, In: Tetrahedron Letters. 59, 52, p. 4587-4592 6 p.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Serum-derived IgG from coxsackievirus A6-infected patients can enhance the infection of peripheral blood mononuclear cells with coxsackievirus A6
Aswathyraj, S., Sane, F., Raghu, C., Sabeena, S., Alidjinou, E. K., Arunkumar, G. & Hober, D., 01-12-2018, In: Microbial Pathogenesis. 125, p. 7-11 5 p.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
2017
Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data
Vastrad, B., Vastrad, C., Godavarthi, A. & Chandrashekar, R., 01-11-2017, In: Medical Oncology. 34, 11, 182.
Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus)
Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage
Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S. M., Hariharapura, R. C., Kalthur, G., Udupa, N. & Mutalik, S., 03-02-2017, In: Drug Delivery. 24, 1, p. 61-74 14 p.
Research output: Contribution to journal › Article › peer-review
65 Citations (Scopus)
2016
Biosynthesis of copper nanoparticles using copper-resistant Bacillus cereus, a soil isolate
Tiwari, M., Jain, P., Chandrashekhar Hariharapura, R., Narayanan, K., Bhat K., U., Udupa, N. & Rao, J. V., 01-10-2016, In: Process Biochemistry. 51, 10, p. 1348-1356 9 p.
Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus)
In vitro wound-healing effects of biosynthesized copper nanoparticles
Tiwari, M., Jain, P., Hariharpura, R. C., Udupa, N. & Rao, J. V., 01-02-2016, In: Asian Journal of Pharmaceutical Sciences. 11, 1, p. 158-159 2 p.
Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)
2015

A pulse radiolysis study of hyperoside isolated from Hypericum mysorense
Hariharapura, R. C., Mahal, H. S., Srinivasan, R., Jagani, H. & Vijayan, P., 2015, In: Radiation Physics and Chemistry. 107, p. 149-159 11 p.
Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)
2014
Investigation of the antioxidant and hepatoprotective potential of Hypericum mysorense
Hariharapura, R. C., Srinivasan, R., Ashok, G., Dongre, S. H., Jagani, H. V. & Vijayan, P., 01-09-2014, In: Antioxidants. 3, 3, p. 526-543 18 p.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
2013

A nanoformulation of siRNA and its role in cancer therapy: In vitro and in vivo evaluation
Jagani, H., Rao, J. V., Palanimuthu, V. R., Hariharapura, R. C. & Gang, S., 2013, In: Cellular and Molecular Biology Letters. 18, 1, p. 120-136 17 p.
Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)
Improvement of therapeutic efficacy of PLGA nanoformulation of siRNA targeting anti-apoptotic Bcl-2 through chitosan coating
Jagani, H. V., Josyula, V. R., Palanimuthu, V. R., Hariharapura, R. C. & Gang, S. S., 2013, In: European Journal of Pharmaceutical Sciences. 48, 4-5, p. 611-618 8 p.
Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)
Profiling of lens protease involved in generation of αA-66-80 crystallin peptide using an internally quenched protease substrate
Hariharapura, R., Santhoshkumar, P. & Krishna Sharma, K., 2013, In: Experimental Eye Research. 109, p. 51-59 9 p.
Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)
2011

Cytotoxicity, platelet aggregation inhibitory and antioxidant activity of Curcuma amada Roxb. extracts
Policegoudra, R. S., Chandrashekhar, R. H., Aradhya, S. M. & Singh, L., 2011, In: Food Technology and Biotechnology. 49, 2, p. 162-168 7 p.
Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)
In vitro anticancer activity of microbial isolates from diverse habitats
Treasathomas, A., Venkata Rao, J., Subrahmanyam, V. M., Chandrashekhar, H. R., Maliyakkal, N., Kisan, T. K., Joseph, A. & Udupa, N., 2011, In: Brazilian Journal of Pharmaceutical Sciences. 47, 2, p. 279-287 9 p.
Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
Nanoformulation of siRNA silencing Bcl-2 gene and its implication in cancer therapy
Jagani, H. V., Josyula, V. R., Hariharapura, R. C., Palanimuthu, V. R. & Gang, S. S. M., 2011, In: Arzneimittel-Forschung/Drug Research. 61, 10, p. 577-586 10 p.
Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)
2010
Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats
Raj, P. V., Nitesh, K., Chandrashekhar, H. R., Mallikarjuna Rao, C., Venkata Rao, J. & Udupa, N., 04-2010, In: Indian Journal of Clinical Biochemistry. 25, 2, p. 169-174 6 p.
Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus)
Hepatoprotective properties of Caesalpinia sappan Linn. heartwood on carbon tetrachloride induced toxicity
Srillakshmi, V. S., Vijayan, P., Raj, P. V., Dhanaraj, S. A. & Chandrashekhar, H. R., 2010, In: Indian Journal of Experimental Biology. 48, 9, p. 905-910 6 p.
Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus)
In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves
Raj, V. P., Chandrasekhar, R. H., Vijayan, P., Dhanaraj, S. A., Rao, M. C., Rao, V. J. & Nitesh, K., 01-03-2010, In: Indian Journal of Pharmacology. 42, 2, p. 99-104 6 p.
Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus)
Potent selective cytotoxic activity of kaempferia galanga L. Rhizome against cancer cell cultures
Jagadish, P. C., H., R. C., Vinod Kumar, S. & Latha, K. P., 2010, In: International Journal of Pharma and Bio Sciences. 1, 2
Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)
Protective role of catechin on D-galactosamine induced hepatotoxicity through a p53 dependent pathway
Vasanth Raj, P., Nitesh, K., Sagar Gang, S., Hitesh Jagani, V., Raghu Chandrashekhar, H., Venkata Rao, J., Mallikarjuna Rao, C. & Udupa, N., 2010, In: Indian Journal of Clinical Biochemistry. 25, 4, p. 349-356 8 p.
Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus)
Single dose vaccine delivery system of tetanus toxoid formulation based on chitosan microspheres
Dineshkumar, B., Dhanaraj, S. A., Santhi, K., Vijayan, P. & Chandrasekhar, R., 01-12-2010, In: International Journal of Advances in Pharmaceutical Sciences. 1, 1, p. 42-49 8 p.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
2009
Antioxidant activity of Hypericum hookerianum Wight and Arn.
Raghu Chandrashekhar, H., Venkatesh, P., Ponnusankar, S. & Vijayan, P., 2009, In: Natural Product Research. 23, 13, p. 1240-1251 12 p.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
Estimation of total phenols with special emphasis to antioxidant potentials of few hypericum species
Raghu Chandrashekhar, H., Venkatesh, P., Arumugam, M. & Vijayan, P., 2009, In: Pharmacologyonline. 1, p. 680-687 8 p.
Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)
Mosquito larvicidal activity of Vitex negundo
Vasanth Raj, P., Raghu Chandrasekhar, H., Dhanaraj, S. A., Vijayan, P., Nitesh, K., Subrahmanyam, V. M. & Venkata Rao, J., 2009, In: Pharmacologyonline. 2, p. 975-990 16 p.
Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
2008
Anti-adipogenic activity of Capsicum annum (Solanaceae) in 3T3 L1
Arumugam, M., Vijayan, P., Raghu, C., Ashok, G., Dhanaraj, S. A. & Kumarappan, C. T., 12-11-2008, In: Journal of Complementary and Integrative Medicine. 5, 1, 28.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Chemoprotective effect of Anogeissus latifolia bark extract on paracetamol-induced hepatotoxicity
Khan, S., Pradeep, H. A., Ashok Kumar, B. S., Anil Kumar, M., Manimaran, S., Chandrasekhar, R. & Vijayan, P., 2008, In: Pharmacologyonline. 2, p. 303-327 25 p.
Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)
In vitro and in vivo hepatoprotective effect of Vitex negundo leaves
Raj, P. V., Chandrasekhar, H. R., Vijayan, P., Dhanaraj, S. A., Rao, C. M., Rao, J. V. & Nitesh, K., 2008, In: Pharmacologyonline. 3, p. 281-295 15 p.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
2007
Antitumor activity of the methanol extract of Hypericum hookerianum stem against ehrlich ascites carcinoma in Swiss albino mice
Dongre, S. H., Badami, S., Natesan, S. & Chandrashekhar H., R., 30-04-2007, In: Journal of Pharmacological Sciences. 103, 4, p. 354-359 6 p.
Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus)
Potent in vitro cytotoxic and antioxidant activity of Careya arborea bark extracts
Senthilkumar, N., Badami, S., Cherian, M. M. & Hariharapura, R. C., 01-05-2007, In: Phytotherapy Research. 21, 5, p. 492-495 4 p.
Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)
Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)
Yar, M. S., Siddiqui, A. A., Ali, M. A., Murugan, V. & Chandrashekhar, R., 01-01-2007, In: Journal of the Chinese Chemical Society. 54, 1, p. 81-86 6 p.
Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)
2006
Synthesis of some amino acids incorporated 4(3H)-quinazolinones as possible antiherpes viral agents
Meyyanathan, S. N., Murali, K. E., Chandrashekhar, H. R., Godavarthi, A., Dhanaraj, S. A., Vijayan, P. & Suresh, B., 01-06-2006, In: Indian Drugs. 43, 6, p. 497-502 6 p.
Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
2005

In vitro cytotoxic properties of Ipomoea aquatica leaf
Prasad, K. N., Ashok, G., Raghu, C., Shivamurthy, G. R., Vijayan, P. & Aradhya, S. M., 01-11-2005, In: Indian Journal of Pharmacology. 37, 6, p. 397-398 2 p.
Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)
2004
Antiviral activity of medicinal plants of Nilgiris
Vijayan, P., Raghu, C., Ashok, G., Dhanaraj, S. A. & Suresh, B., 01-07-2004, In: Indian Journal of Medical Research. 120, 1, p. 24-29 6 p.
Research output: Contribution to journal › Article › peer-review
175 Citations (Scopus)
Free radical scavenging activity of selected essential oils
Ashok, G., Raghu, C., Dhanaraj, S. A., Suresh, B. & Vijayan, P., 01-04-2004, In: Indian Drugs. 41, 4, p. 244-245 2 p.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
The cytotoxic activity of the total alkaloids isolated from different parts of Solanum pseudocapsicum
Vijayan, P., Vijayaraj, P., Setty, P. H. C., Hariharpura, R. C., Godavarthi, A., Badami, S., Arumugam, D. S. & Bhojraj, S., 01-04-2004, In: Biological and Pharmaceutical Bulletin. 27, 4, p. 528-530 3 p.
Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus)

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