• Madhava Nagar, Manipal, Karnataka State. Pin 576104

    India

  • Madhav Nagar, MCOPS Building

    576104 Manipal

    India

  • 2237 Citations
  • 26 h-Index
20012020
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Research Output 2001 2020

  • 2237 Citations
  • 26 h-Index
  • 107 Article
  • 10 Review article
  • 1 Chapter
  • 1 Letter
2020
Mental Competency
Oocytes
Spermatozoa
Tuberculosis
Ethambutol
Alzheimer Disease
Nanotechnology
Peptide Aptamers
Exosomes
Quantum Dots

Surface engineered nanoliposomal platform for selective lymphatic uptake of asenapine maleate: In vitro and in vivo studies

Managuli, R. S., Wang, J. T. W., Faruqu, F. M., Pandey, A., Jain, S., Al-Jamal, K. T. & Mutalik, S., 04-2020, In : Materials Science and Engineering C. 109, 110620.

Research output: Contribution to journalArticle

maleates
Liposomes
drugs
platforms
bioavailability
2019
5 Citations (Scopus)

Active Targeting of Drugs and Bioactive Molecules via Oral Administration by Ligand-Conjugated Lipidic Nanocarriers: Recent Advances

Shreya, A. B., Raut, S. Y., Managuli, R. S., Udupa, N. & Mutalik, S., 01-01-2019, In : AAPS PharmSciTech. 20, 1, 15.

Research output: Contribution to journalReview article

Nanotechnology
Drug Delivery Systems
oral administration
Oral Administration
mouth

Application of hot melt extrusion for the solubility enhancement of a BCS class II drug

Kumar, A. M. S., Kulyadi, G. P., Mutalik, S., Kulkarni, V. I. & Tippavajhala, V. K., 08-2019, In : Research Journal of Pharmacy and Technology. 12, 8, p. 3751-3754 4 p.

Research output: Contribution to journalArticle

Solubility
Polymers
Pharmaceutical Preparations
Acetaminophen
Water
1 Citation (Scopus)

Asenapine maleate-loaded nanostructured lipid carriers: Optimization and in vitro, ex vivo and in vivo evaluations

Managuli, R. S., Wang, J. T., Faruqu, F. N., Kushwah, V., Raut, S. Y., Shreya, A. B., Al-Jamal, K. T., Jain, S. & Mutalik, S., 01-04-2019, In : Nanomedicine. 14, 7, p. 889-910 22 p.

Research output: Contribution to journalArticle

Lipids
Biological Availability
Pharmaceutical Preparations
Carbidopa
Differential Scanning Calorimetry
1 Citation (Scopus)
Seed
Silver
Nanoparticles
Biodiesel
Salts

Challenges in the development of analytical test procedure for aminoglycosides: A critical review

Hari, R., Taherunnisa, S., Raut, S. Y., Mutalik, S. & Koteshwara, K. B., 01-01-2019, In : Journal of Applied Pharmaceutical Science. 9, 11, p. 145-152 8 p.

Research output: Contribution to journalArticle

Open Access
Aminoglycosides
formic acid
Radioimmunoassay
Buffers
Enzyme-Linked Immunosorbent Assay
2 Citations (Scopus)

Cyclodextrins as Carriers in Targeted Delivery of Therapeutic Agents: Focused Review on Traditional and Inimitable Applications

Raut, S. Y., Manne, A. S. N., Kalthur, G., Jain, S. & Mutalik, S., 01-01-2019, In : Current Pharmaceutical Design. 25, 4, p. 444-454 11 p.

Research output: Contribution to journalArticle

Cyclodextrins
Pharmaceutical Preparations
Drug Delivery Systems
Therapeutics
Drug Carriers

Heterogeneous surface-modified nanoplatforms for the targeted therapy of haematological malignancies

Kulkarni, S., Pandey, A. & Mutalik, S., 01-01-2019, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Peptide Nucleic Acids
Phototherapy
Golgi Apparatus
Complementary Therapies
5 Citations (Scopus)
Nanocomposites
Diclofenac
Microspheres
Polymers
Pharmaceutical Preparations
1 Citation (Scopus)

Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo evaluation

Boppana, R., Yadaorao Raut, S., Krishna Mohan, G., Sa, B., Mutalik, S., Reddy, K. R., Das, K. K., Biradar, M. S. & Kulkarni, R. V., 01-08-2019, In : Colloids and Surfaces B: Biointerfaces. 180, p. 362-370 9 p.

Research output: Contribution to journalArticle

locusts
Ketoprofen
Sodium alginate
Polyacrylates
sodium
2 Citations (Scopus)
Skin
Pharmaceutical Preparations
Bipolar Disorder
Antipsychotic Agents
Biological Availability
1 Citation (Scopus)

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems

Shirodkar, R. K., Kumar, L., Mutalik, S. & Lewis, S., 01-08-2019, In : Pharmaceutical Chemistry Journal. 53, 5, p. 440-453 14 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Nanoparticles
Lipids
Pharmaceutical Preparations
Biological Availability

Supplementation of biotin to sperm preparation medium enhances fertilizing ability of spermatozoa and improves preimplantation embryo development

Salian, S. R., Nayak, G., Kumari, S., Patel, S., Gowda, S., Shenoy, Y., Sugunan, S., G.K, R., Managuli, R. S., Mutalik, S., Dahiya, V., Pal, S., Adiga, S. K. & Kalthur, G., 15-02-2019, In : Journal of Assisted Reproduction and Genetics. 36, 2, p. 255-266 12 p.

Research output: Contribution to journalArticle

Biotin
Embryonic Development
Spermatozoa
Pentoxifylline
Fertilization
2 Citations (Scopus)

Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform: A biomedical and toxicological perspective

Dhas, N., Parekh, K., Pandey, A., Kudarha, R., Mutalik, S. & Mehta, T., 28-08-2019, In : Journal of Controlled Release. 308, p. 130-161 32 p.

Research output: Contribution to journalReview article

Nanocomposites
Graphite
Toxicology
Carbon
Nanomedicine
2018
1 Citation (Scopus)

Delving deeper into dermal and transdermal drug delivery: Factors and mechanisms associated with nanocarrier-mediated strategies

Manikkath, J., Sumathy, T. K., Manikkath, A. & Mutalik, S., 01-01-2018, In : Current Pharmaceutical Design. 24, 27, p. 3210-3222 13 p.

Research output: Contribution to journalReview article

Skin
Pharmaceutical Preparations
Drug Administration Routes
Drug Carriers
Particle Size
1 Citation (Scopus)
letrozole
Design of experiments
Research Design
Liquids
Flow rate
8 Citations (Scopus)

Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In : International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

Research output: Contribution to journalArticle

Chitosan
Nanoparticles
Pharmacodynamics
Pharmacokinetics
Pharmaceutical Preparations
3 Citations (Scopus)
gemcitabine
Iontophoresis
Skin
Pharmaceutical Preparations
HEPES
3 Citations (Scopus)

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Joshi, H., Hegde, A. R., Shetty, P. K., Gollavilli, H., Managuli, R. S., Kalthur, G. & Mutalik, S., 01-01-2018, In : Photodermatology Photoimmunology and Photomedicine. 34, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

Sunscreening Agents
Nanoparticles
Skin
In Vitro Techniques
naringenin
8 Citations (Scopus)

Targeting the intestinal lymphatic system: a versatile path for enhanced oral bioavailability of drugs

Managuli, R. S., Raut, S. Y., Reddy, M. S. & Mutalik, S., 03-08-2018, In : Expert Opinion on Drug Delivery. 15, 8, p. 787-804 18 p.

Research output: Contribution to journalReview article

Lymphatic System
Biological Availability
Nanoparticles
Pharmaceutical Preparations
Peyer's Patches
2017
8 Citations (Scopus)

A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: Tumor-specific homing directed by nestin

Prabhu, S., Goda, J. S., Mutalik, S., Mohanty, B. S., Chaudhari, P., Rai, S., Udupa, N. & Rao, B. S. S., 14-08-2017, In : Nanoscale. 9, 30, p. 10919-10932 14 p.

Research output: Contribution to journalArticle

temozolomide
Nestin
Heterografts
Tumors
Nanocomposites
4 Citations (Scopus)
Chitosan
Scaffolds
Wound Healing
Curcumin
Electron Scanning Microscopy
1 Citation (Scopus)

Characterization of the Phenolic Compound, Gallic Acid from Sansevieria roxburghiana Schult and Schult. f. Rhizomes and Antioxidant and Cytotoxic Activities Evaluation

Maheshwari, R., Shreedhara, C. S., Polu, P. R., Managuli, R. S., Xavier, S. K., Lobo, R., Setty, M. & Mutalik, S., 11-10-2017, In : Pharmacognosy Magazine. 13, 51, p. S693-S699

Research output: Contribution to journalArticle

Sansevieria
Gallic Acid
Rhizome
Antioxidants
lissamine rhodamine B
3 Citations (Scopus)
Nanocomposites
Heterografts
Toxicity
Cells
Breast Neoplasms
1 Citation (Scopus)
Haploidy
Ammonia
Embryonic Structures
Blastocyst
Parthenogenesis
5 Citations (Scopus)
Propolis
Mitomycin
DNA Damage
Antioxidants
Fertility Preservation
24 Citations (Scopus)

Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

Manikkath, J., Hegde, A. R., Kalthur, G., Parekh, H. S. & Mutalik, S., 15-04-2017, In : International Journal of Pharmaceutics. 521, 1-2, p. 110-119 10 p.

Research output: Contribution to journalArticle

Ketoprofen
Dendrimers
Peptides
Pharmaceutical Preparations
Arginine
2 Citations (Scopus)
Inositol
Liposomes
Glycerol
Oocytes
Blastocyst
11 Citations (Scopus)

Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen

Manikkath, J., Manikkath, A., Shavi, G. V., Bhat, K. & Mutalik, S., 01-10-2017, In : Journal of Drug Delivery Science and Technology. 41, p. 334-343 10 p.

Research output: Contribution to journalArticle

Ketoprofen
Dendrimers
Skin
Pharmaceutical Preparations
Drug Combinations
19 Citations (Scopus)
Ketoprofen
Dendrimers
Iontophoresis
Skin
Peptides
3 Citations (Scopus)

Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP-HPLC method

Managuli, R. S., Gourishetti, K., Shenoy, R. R., Koteshwara, K. B., Reddy, M. S. & Mutalik, S., 01-07-2017, In : Bioanalysis. 9, 14, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Pharmacokinetics
High Pressure Liquid Chromatography
Tissue
Liquid-Liquid Extraction
Liquids
11 Citations (Scopus)

Skin Delivery of EGCG and Silibinin: Potential of Peptide Dendrimers for Enhanced Skin Permeation and Deposition

Shetty, P. K., Manikkath, J., Tupally, K., Kokil, G., Hegde, A. R., Raut, S. Y., Parekh, H. S. & Mutalik, S., 01-08-2017, In : AAPS PharmSciTech. 18, 6, p. 2346-2357 12 p.

Research output: Contribution to journalArticle

Dendrimers
epigallocatechin
peptides
Skin
Peptides
30 Citations (Scopus)

Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S. M., Hariharapura, R. C., Kalthur, G., Udupa, N. & Mutalik, S., 03-02-2017, In : Drug Delivery. 24, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Antioxidants
Radiation
Skin
Differential Scanning Calorimetry
1 Citation (Scopus)

Sperm-derived factors enhance the in vitro developmental potential of haploid parthenotes

Nair, R., Aboobacker, S., Mutalik, S., Kalthur, G. & Adiga, S. K., 28-11-2017, (Accepted/In press) In : Zygote. p. 1-14 14 p.

Research output: Contribution to journalArticle

Haploidy
Spermatozoa
Oocytes
Status Epilepticus
Zygote
11 Citations (Scopus)

Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa

Isaac, A. V., Kumari, S., Nair, R., Urs, D. R., Salian, S. R., Kalthur, G., Adiga, S. K., Manikkath, J., Mutalik, S., Sachdev, D. & Pasricha, R., 16-12-2017, In : Biochemical and Biophysical Research Communications. 494, 3-4, p. 656-662 7 p.

Research output: Contribution to journalArticle

Zinc Oxide
Cryopreservation
Nanoparticles
Spermatozoa
Fluorescence microscopy
2016
12 Citations (Scopus)

Aeromonas hydrophila OmpW PLGA nanoparticle oral vaccine shows a dose-dependent protective immunity in rohu (Labeo rohita)

Dubey, S., Avadhani, K., Mutalik, S., Sivadasan, S. M., Maiti, B., Paul, J., Girisha, S. K., Venugopal, M. N., Mutoloki, S., Evensen, Ø., Karunasagar, I. & Munang’andu, H. M., 01-06-2016, In : Vaccines. 4, 2, 21.

Research output: Contribution to journalArticle

glycolic acid
Aeromonas hydrophila
Nanoparticles
Immunity
Vaccines
5 Citations (Scopus)

A novel nanoproliposomes of lercanidipine: Development, in vitro and preclinical studies to support its effectiveness in hypertension therapy

Deshpande, P. B., Gurram, A. K., Deshpande, A., Shavi, G. V., Musmade, P., Arumugam, K., Averineni, R. K., Mutalik, S., Reddy, M. S. & Udupa, N., 01-10-2016, In : Life Sciences. 162, p. 125-137 13 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Rats
Pharmacokinetics
Hypertension
Particle Size

An overview of novel and controlled drug delivery systems

Nayak, U. Y., Mutalik, S. & Udupa, N., 01-05-2016, In : Indian Drugs. 53, 5, p. 5-12 8 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Pharmaceutical Preparations
Dosage Forms
Life Cycle Stages
Biological Availability

Determination of antibacterial and antifungal properties of rose extract- An in vitro study

Bahl, D., Karande, S., Chakravarthy, A., Mutalik, S. & Devkar, R., 2016, In : International Journal of Pharmacognosy and Phytochemical Research. 8, 10, p. 1695-1697 3 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

Mutalik, S., Suthar, N. A., Managuli, R. S., Shetty, P. K., Avadhani, K., Kalthur, G., Kulkarni, R. V. & Thomas, R., 01-05-2016, In : International Journal of Biological Macromolecules. 86, p. 709-720 12 p.

Research output: Contribution to journalArticle

Curcumin
Nanoparticles
Copolymers
Inflammatory Bowel Diseases
Rats
2 Citations (Scopus)

Development and validation of a reverse phase HPLC method for the estimation of lacidipine in rat plasma: Application to preclinical pharmacokinetics

Shirodkar, R. K., Kumar, L., Misra, C., Managuli, R., Attari, Z., Mutalik, S. & Lewis, S. A., 2016, In : Latin American Journal of Pharmacy. 35, 1, p. 124-129 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
High Pressure Liquid Chromatography
Felodipine
Oral Administration
Wistar Rats
9 Citations (Scopus)
Lipids
Degradation
Analysis of variance (ANOVA)
Asenapine
Flow rate
1 Citation (Scopus)
High Pressure Liquid Chromatography
Lipids
Antioxidants
Free Radical Scavengers
Immunologic Factors
19 Citations (Scopus)
Nanoparticles
Biological Availability
Permeability
Mouth Mucosa
Angina Pectoris
8 Citations (Scopus)

Edwardsiella tarda OmpA encapsulated in chitosan nanoparticles shows superior protection over inactivated whole cell vaccine in orally vaccinated fringed-lipped peninsula carp (Labeo fimbriatus)

Dubey, S., Avadhani, K., Mutalik, S., Sivadasan, S. M., Maiti, B., Girisha, S. K., Venugopal, M. N., Mutoloki, S., Evensen, Ø., Karunasagar, I. & Munang’andu, H. M., 01-12-2016, In : Vaccines. 4, 4, 40.

Research output: Contribution to journalArticle

Edwardsiella tarda
Carps
Chitosan
Nanoparticles
Vaccines
3 Citations (Scopus)

Ethambutol induces testicular damage and decreases the sperm functional competence in Swiss albino mice

Rao, A., Nayak, G., Kumari, S., Prabhu, A. D., Khandige, N., Kalthur, S. G., Mutalik, S., Kalthur, G. & Adiga, S. K., 01-10-2016, In : Environmental Toxicology and Pharmacology. 47, p. 28-37 10 p.

Research output: Contribution to journalArticle

Ethambutol
Mental Competency
Spermatozoa
Sperm Head
Sperm Count
11 Citations (Scopus)

Ethanolic extract of Moringa oleifera Lam. leaves protect the pre-pubertal spermatogonial cells from cyclophosphamide-induced damage

Nayak, G., Honguntikar, S. D., Kalthur, S. G., D'Souza, A. S., Mutalik, S., Setty, M. M., Kalyankumar, R., Krishnamurthy, H., Kalthur, G. & Adiga, S. K., 22-04-2016, In : Journal of Ethnopharmacology. 182, p. 101-109 9 p.

Research output: Contribution to journalArticle

Moringa oleifera
Germ Cells
Cyclophosphamide
DNA Damage
Body Weight
8 Citations (Scopus)

In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen

Boppana, R., Kulkarni, R. V., Mohan, G. K., Mutalik, S. & Aminabhavi, T. M., 2016, In : RSC Advances. 6, 69, p. 64344-64356 13 p.

Research output: Contribution to journalArticle

Ketoprofen
Interpenetrating polymer networks
Graft copolymers
Copolymers
Sodium alginate