β-Thalassemia hijacking ineffective erythropoietin and iron overload: Two case reports and a review of literature

Aditi A. Byatnal, Aditi A. Byatnal, M. K Parvathi Devi, B. Badriramkrishna

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Abstract

Thalassemia is a rare, complex disease, representing a group of disorders of hemoglobin synthesis that are characterized by reduced synthesis of either the alpha-globin or β-globin chains of the hemoglobin molecule. Defective synthesis of β-globin resulting from a variety of molecular defects causes β-thalassemia. Thalassemia is an autosomal recessive disorder, which requires prompt diagnosis and an appropriate treatment. Thorough clinical, radiographic and laboratory assessment helps in diagnosing thalassemia and any other hematological disorder. Here, two cases of β-thalassemia showing distinct features are presented and the importance of detailed work-up of the cases has been highlighted.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalJournal of Natural Science, Biology and Medicine
Volume5
Issue number2
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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