Cerotato de 1-triacontanol aislado de marsilea quadrifolia linn. Protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas

Translated title of the contribution: 1-triacontanol cerotate isolated from marsilea quadrifolia linn. Safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic rats

Adhikari Snehunsu, Satheesha B. Nayak, Mamta Kandwal, Adhikari Piyali, Murali Adiga, Pabitra Sahoo, T. Medabala, K. Raghavenra Rao, Alex Joseph

Research output: Contribution to journalArticle

Abstract

Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC: 40 mg/kg) & VI (1TAC: 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.

Original languageSpanish
Pages (from-to)265-272
Number of pages8
JournalInternational Journal of Morphology
Volume37
Issue number1
DOIs
Publication statusPublished - 01-01-2019

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Marsileaceae
Memory Disorders
Neurons
Anticonvulsants
Epilepsy
Pentylenetetrazole
Hippocampal CA3 Region
Pyramidal Cells
Wistar Rats
Seizures
hexacosanoic acid
1-triacontanol
Learning
Water
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Anatomy

Cite this

Snehunsu, Adhikari ; Nayak, Satheesha B. ; Kandwal, Mamta ; Piyali, Adhikari ; Adiga, Murali ; Sahoo, Pabitra ; Medabala, T. ; Rao, K. Raghavenra ; Joseph, Alex. / Cerotato de 1-triacontanol aislado de marsilea quadrifolia linn. Protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas. In: International Journal of Morphology. 2019 ; Vol. 37, No. 1. pp. 265-272.
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abstract = "Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC: 40 mg/kg) & VI (1TAC: 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.",
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Cerotato de 1-triacontanol aislado de marsilea quadrifolia linn. Protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas. / Snehunsu, Adhikari; Nayak, Satheesha B.; Kandwal, Mamta; Piyali, Adhikari; Adiga, Murali; Sahoo, Pabitra; Medabala, T.; Rao, K. Raghavenra; Joseph, Alex.

In: International Journal of Morphology, Vol. 37, No. 1, 01.01.2019, p. 265-272.

Research output: Contribution to journalArticle

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AU - Snehunsu, Adhikari

AU - Nayak, Satheesha B.

AU - Kandwal, Mamta

AU - Piyali, Adhikari

AU - Adiga, Murali

AU - Sahoo, Pabitra

AU - Medabala, T.

AU - Rao, K. Raghavenra

AU - Joseph, Alex

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