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  Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing method for solubility and bioavailability enhancement of drugs

  Manne, A. S. N., Hegde, A. R., Raut, S. Y., Rao, R. R., Kulkarni, V. I. & Mutalik, S., 2020, (Accepted/In press) In: Drug Delivery and Translational Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclodextrins
  • Solubility
  • Biological Availability
  • 2-Hydroxypropyl-beta-cyclodextrin
  • Pharmaceutical Preparations

• Hyaluronic acid-drug conjugate modified core-shell MOFs as pH responsive nanoplatform for multimodal therapy of glioblastoma

  Pandey, A., Kulkarni, S., Vincent, A. P., Nannuri, S. H., George, S. D. & Mutalik, S., 15-10-2020, In: International Journal of Pharmaceutics. 588, 119735.

  Research output: Contribution to journal › Article › peer-review

  • Lactoferrin
  • Nanocomposites
  • Hyaluronic Acid
  • Glioblastoma
  • Pharmaceutical Preparations
  1 Citation (Scopus)

• Indian propolis ameliorates the mitomycin C-induced testicular toxicity by reducing DNA damage and elevating the antioxidant activity

  Kumari, S., Nayak, G., Lukose, S. T., Kalthur, S. G., Bhat, N., Hegde, A. R., Mutalik, S., Kalthur, G. & Adiga, S. K., 01-11-2017, In: Biomedicine and Pharmacotherapy. 95, p. 252-263 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Propolis
  • Mitomycin
  • DNA Damage
  • Antioxidants
  • Fertility Preservation
  7 Citations (Scopus)

• Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

  Manikkath, J., Hegde, A. R., Kalthur, G., Parekh, H. S. & Mutalik, S., 15-04-2017, In: International Journal of Pharmaceutics. 521, 1-2, p. 110-119 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Ketoprofen
  • Peptides
  • Arginine
  • Pharmaceutical Preparations
  33 Citations (Scopus)

• Interpenetrating polymer network microcapsules of gellan gum and egg albumin entrapped with diltiazem-resin complex for controlled release application

  Kulkarni, R. V., Mangond, B. S., Mutalik, S. & Sa, B., 2011, In: Carbohydrate Polymers. 83, 2, p. 1001-1007 7 p.

  Research output: Contribution to journal › Article › peer-review
  80 Citations (Scopus)

• Intraoral slow-releasing polymeric patches containing sodium fluoride and chlorhexidine: Development and evaluation

  Karuna, Y. M., Nayak, A. P., Pralhad, S., Mutalik, S. & Padya, B. S., 10-2020, In: Journal of Applied Pharmaceutical Science. 10, 10, p. 30-35 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sodium Fluoride
  • Chlorhexidine
  • Fluorides
  • Dental Caries
  • Anti-Infective Agents

• In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen

  Boppana, R., Kulkarni, R. V., Mohan, G. K., Mutalik, S. & Aminabhavi, T. M., 2016, In: RSC Advances. 6, 69, p. 64344-64356 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Graft copolymers
  • Microbeads
  • Interpenetrating polymer networks
  • Ketoprofen
  • Copolymers
  10 Citations (Scopus)

• In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold

  Amirthalingam, M., Kasinathan, N., Mutalik, S. & Udupa, N., 19-05-2015, In: Journal of Microencapsulation. 32, 4, p. 364-371 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitosan
  • Biocompatibility
  • biocompatibility
  • Scaffolds
  • Curcumin
  5 Citations (Scopus)

• Iontophoresis-mediated transdermal permeation of peptide dendrimers across human epidermis

  Mutalik, S., Parekh, H. S., Anissimov, Y. G., Grice, J. E. & Roberts, M. S., 2013, In: Skin Pharmacology and Physiology. 26, 3, p. 127-138 12 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Lidocaine Transdermal Patch: Pharmacokinetic Modeling and In Vitro–In Vivo Correlation (IVIVC)

  Kondamudi, P. K., Tirumalasetty, P. P., Malayandi, R., Mutalik, S. & Pillai, R., 2016, In: AAPS PharmSciTech. 17, 3, p. 588-596 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Transdermal Patch
  • lidocaine
  • Lidocaine
  • pharmacokinetics
  • Pharmacokinetics
  10 Citations (Scopus)

• Liposome-encapsulated diacyl glycerol and inositol triphosphate-induced delayed oocyte activation and poor development of parthenotes

  Nair, R., Manikkath, J., Hegde, A. R., Mutalik, S., Kalthur, G. & Adiga, S. K., 01-09-2017, In: Journal of the Turkish German Gynecology Association. 18, 3, p. 102-109 8 p.

  Research output: Contribution to journal › Article › peer-review

  • triphosphoric acid
  • Inositol
  • Glycerol
  • dipalmitin
  • Liposomes
  2 Citations (Scopus)

• Liposome encapsulated soy lecithin and cholesterol can efficiently replace chicken egg yolk in human semen cryopreservation medium

  Mutalik, S., Salian, S. R., Avadhani, K., Menon, J., Joshi, H., Hegde, A. R., Kumar, P., Kalthur, G. & Adiga, S. K., 2014, In: Systems Biology in Reproductive Medicine. 60, 3, p. 183-188 6 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen

  Manikkath, J., Manikkath, A., Shavi, G. V., Bhat, K. & Mutalik, S., 01-10-2017, In: Journal of Drug Delivery Science and Technology. 41, p. 334-343 10 p.

  Research output: Contribution to journal › Article › peer-review

  • PAMAM Starburst
  • Ketoprofen
  • Dendrimers
  • Skin
  • Pharmaceutical Preparations
  15 Citations (Scopus)

• Lymphatic delivery of anti-HIV drug nanoparticles

  Nayak, Y., Avadhani, K., Mutalik, S. & Nayak, U. Y., 01-08-2016, In: Recent Patents on Nanotechnology. 10, 2, p. 116-127 12 p.

  Research output: Contribution to journal › Article › peer-review

  • human immunodeficiency virus
  • Anti-HIV Agents
  • drugs
  • Nanoparticles
  • lymphatic system
  7 Citations (Scopus)

• Methyl parathion inhibits the nuclear maturation, decreases the cytoplasmic quality in oocytes and alters the developmental potential of embryos of Swiss albino mice

  Nair, R., Singh, V. J., Salian, S. R., Kalthur, S. G., D'Souza, A. S., Shetty, P. K., Mutalik, S., Kalthur, G. & Adiga, S. K., 2014, In: Toxicology and Applied Pharmacology. 279, 3, p. 338-350 13 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Mitigating effect of Indian propolis against mitomycin C induced bone marrow toxicity

  Kumari, S., Naik, P., Vishma, B. L., Salian, S. R., Devkar, R. A., Khan, S., Mutalik, S., Kalthur, G. & Adiga, S. K., 01-10-2016, In: Cytotechnology. 68, 5, p. 1789-1800 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Propolis
  • Lipids
  • Toxicity
  • Assays
  • Mitomycin
  8 Citations (Scopus)

• Multidrug resistant pathogenic bacterial biofilm inhibition by Lactobacillus plantarum exopolysaccharide

  Pradeepa, Shetty, A. D., Matthews, K., Hegde, A. R., Akshatha, B., Mathias, A. B., Mutalik, S. & Vidya, S. M., 01-07-2016, In: Bioactive Carbohydrates and Dietary Fibre. 8, 1, p. 7-14 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lactobacillus plantarum
  • Biofilms
  • exopolysaccharides
  • biofilm
  • Cell Communication
  8 Citations (Scopus)

• Nano-transfersomal formulations for transdermal delivery of asenapine maleate: in vitro and in vivo performance evaluations

  Shreya, A. B., Managuli, R. S., Menon, J., Kondapalli, L., Hegde, A. R., Avadhani, K., Shetty, P. K., Amirthalingam, M., Kalthur, G. & Mutalik, S., 02-07-2016, In: Journal of Liposome Research. 26, 3, p. 221-232 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Asenapine
  • Biological Availability
  • In Vitro Techniques
  • Deoxycholic Acid
  • Skin
  32 Citations (Scopus)

• Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation

  Gollavilli, H., Hegde, A. R., Managuli, R. S., Bhaskar, K. V., Dengale, S. J., Reddy, M. S., Kalthur, G. & Mutalik, S., 09-2020, In: Colloids and Surfaces B: Biointerfaces. 193, 111122.

  Research output: Contribution to journal › Article › peer-review

  • Sun hoods
  • naringin
  • antioxidants
  • Sunscreening Agents
  • drugs
  3 Citations (Scopus)

• Novel interpenetrated polymer network microbeads of natural polysaccharides for modified release of water soluble drug: In-vitro and in-vivo evaluation

  Kulkarni, R. V., Mutalik, S., Mangond, B. S. & Nayak, U. Y., 2012, In: Journal of Pharmacy and Pharmacology. 64, 4, p. 530-540 11 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Novel pH-sensitive IPNs of polyacrylamide-g-gum ghatti and sodium alginate for gastro-protective drug delivery

  Boppana, R., Krishna Mohan, G., Nayak, U., Mutalik, S., Sa, B. & Kulkarni, R. V., 2015, In: International Journal of Biological Macromolecules. 75, p. 133-143 11 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Pediatric dosage forms-challenges and recent developments: A critical review

  Galande, A. D., Khurana, N. A. & Mutalik, S., 01-07-2020, In: Journal of Applied Pharmaceutical Science. 10, 7, p. 155-166 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dosage Forms
  • Pediatrics
  • Off-Label Use
  • Age Groups
  • Excipients
  1 Citation (Scopus)

• PEGylation of superparamagnetic iron oxide nanoparticle for drug delivery applications with decreased toxicity: an in vivo study

  Prabhu, S., Mutalik, S., Rai, S., Udupa, N. & Rao, B. S. S., 01-10-2015, In: Journal of Nanoparticle Research. 17, 10, 412.

  Research output: Contribution to journal › Article › peer-review

  • Drug Delivery
  • Nanoparticles
  • Oxides
  • Drug delivery
  • Iron
  15 Citations (Scopus)

• Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery

  Hegde, A. R., Rewatkar, P. V., Manikkath, J., Tupally, K., Parekh, H. S. & Mutalik, S., 01-05-2017, In: European Journal of Pharmaceutical Sciences. 102, p. 237-249 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Ketoprofen
  • Iontophoresis
  • Peptides
  • Skin
  24 Citations (Scopus)

• PH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in vivo evaluation

  Kulkarni, R. V., Boppana, R., Krishna Mohan, G., Mutalik, S. & Kalyane, N. V., 2012, In: Journal of Colloid and Interface Science. 367, 1, p. 509-517 9 p.

  Research output: Contribution to journal › Article › peer-review
  102 Citations (Scopus)

• Polymethacrylate coated valsartan tablets for ileo-colonic delivery: Formulation development and in vitro and in vivo evaluations

  Nayak, U. Y., Mutalik, S. & Nayak, Y., 2013, In: Research Journal of Pharmacy and Technology. 6, 12, p. 1362-1369 8 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP-HPLC method

  Managuli, R. S., Gourishetti, K., Shenoy, R. R., Koteshwara, K. B., Reddy, M. S. & Mutalik, S., 01-07-2017, In: Bioanalysis. 9, 14, p. 1037-1047 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Asenapine
  • Pharmacokinetics
  • High Pressure Liquid Chromatography
  • Tissue
  • Liquid-Liquid Extraction
  4 Citations (Scopus)

• Preparation, characterization and pharmacokinetic study of nelfinavir nanocrystals for oral bioavailability enhancement

  Naresh, D. N., Nayak, U. Y., Musmade, P., Mutalik, S. & Nayak, Y., 2015, In: Current Nanoscience. 11, 3, p. 379-387 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Biological Availability
  • Nelfinavir
  • Nanocrystals
  • Pharmacokinetics
  • Nanoparticles
  2 Citations (Scopus)

• Preparation of gold nanoparticles by novel bacterial exopolysaccharide for antibiotic delivery

  Pradeepa, Vidya, S. M., Mutalik, S., Udaya Bhat, K., Huilgol, P. & Avadhani, K., 15-05-2016, In: Life Sciences. 153, p. 171-179 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gold nanoparticles
  • Nanostructures
  • Assays
  • Bacteria
  • Gold
  24 Citations (Scopus)

• Quinoline Derivative Enhances Human Sperm Motility and Improves the Functional Competence

  Kumari, S., Salian, S. R., Rao, A., Somagond, S. M., Kamble, R. R., Nesaragi, A., Das, J., Rajanikant, G. K., Mutalik, S., Raghu, S. V., Adiga, S. K. & Kalthur, G., 2020, (Accepted/In press) In: Reproductive Sciences.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • quinoline
  • Sperm Motility
  • Mental Competency
  • Spermatozoa
  • Blastocyst

• Skin Delivery of EGCG and Silibinin: Potential of Peptide Dendrimers for Enhanced Skin Permeation and Deposition

  Shetty, P. K., Manikkath, J., Tupally, K., Kokil, G., Hegde, A. R., Raut, S. Y., Parekh, H. S. & Mutalik, S., 01-08-2017, In: AAPS PharmSciTech. 18, 6, p. 2346-2357 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Silybin
  • Dendrimers
  • epigallocatechin gallate
  • Peptides
  • Skin
  19 Citations (Scopus)

• Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

  Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S. M., Hariharapura, R. C., Kalthur, G., Udupa, N. & Mutalik, S., 03-02-2017, In: Drug Delivery. 24, 1, p. 61-74 14 p.

  Research output: Contribution to journal › Article › peer-review

  • epigallocatechin gallate
  • Hyaluronic Acid
  • Ultraviolet Rays
  • Antioxidants
  • Skin
  65 Citations (Scopus)

• Sonophoresis-mediated permeation and retention of peptide dendrimers across human epidermis

  Mutalik, S., Nayak, U. Y., Kalra, R., Kumar, A., Kulkarni, R. V. & Parekh, H. S., 2012, In: Skin Research and Technology. 18, 1, p. 101-107 7 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Sperm abnormalities induced by pre-pubertal exposure to cyclophosphamide are effectively mitigated by Moringa oleifera leaf extract

  Nayak, G., Vadinkar, A., Nair, S., Kalthur, S. G., D'Souza, A. S., Shetty, P. K., Mutalik, S., Shetty, M. M., Kalthur, G. & Adiga, S. K., 01-03-2016, In: Andrologia. 48, 2, p. 125-136 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Moringa oleifera
  • Cyclophosphamide
  • Spermatozoa
  • Injections
  • DNA Damage
  25 Citations (Scopus)

• Sperm-derived factors enhance the in vitro developmental potential of haploid parthenotes

  Nair, R., Aboobacker, S., Mutalik, S., Kalthur, G. & Adiga, S. K., 01-12-2017, In: Zygote. p. 1-14 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Haploidy
  • Spermatozoa
  • Oocytes
  • In Vitro Techniques
  • strontium chloride
  1 Citation (Scopus)

• Strategic design of dicer substrate siRNA to mitigate the resistance mediated by ABCC1 in doxorubicinresistant breast cancer

  Gatta, A. K., Chandrashekhar, R., Udupa, N., Reddy, M. S., Mutalik, S. & Josyula, V. R., 04-2020, In: Indian Journal of Pharmaceutical Sciences. 82, 2, p. 329-340 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Doxorubicin
  • Nanoparticles
  • Small Interfering RNA
  • Folic Acid
  • RNA

• Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats

  Shirodkar, R., Misra, C., Gh, C., Shetty, P., Attari, Z., Mutalik, S. & Lewis, S., 2015, In: Scientific World Journal. 2015

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Subacute toxicity study of lacidipine nanoformulation

  Shirodkar, R., Reddy, N., Kumar, N., Ramalingayya, G., Mutalik, S. & Lewis, S., 26-09-2015, In: Latin American Journal of Pharmacy. 34, 8, p. 1526-1533 8 p.

  Research output: Contribution to journal › Article › peer-review

  • lacidipine
  • Nanoparticles
  • Lipids
  • Body Weight
  • Drug Compounding
  2 Citations (Scopus)

• Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa

  Isaac, A. V., Kumari, S., Nair, R., Urs, D. R., Salian, S. R., Kalthur, G., Adiga, S. K., Manikkath, J., Mutalik, S., Sachdev, D. & Pasricha, R., 16-12-2017, In: Biochemical and Biophysical Research Communications. 494, 3-4, p. 656-662 7 p.

  Research output: Contribution to journal › Article › peer-review

  • ZnO nanoparticles
  • Zinc Oxide
  • Cryopreservation
  • Spermatozoa
  • Nanoparticles
  21 Citations (Scopus)

• Surface engineered nanoliposomal platform for selective lymphatic uptake of asenapine maleate: In vitro and in vivo studies

  Managuli, R. S., Wang, J. T. W., Faruqu, F. M., Pandey, A., Jain, S., Al-Jamal, K. T. & Mutalik, S., 04-2020, In: Materials Science and Engineering C. 109, 110620.

  Research output: Contribution to journal › Article › peer-review

  • Asenapine
  • maleates
  • Liposomes
  • drugs
  • platforms
  7 Citations (Scopus)

• Surface-engineered nanoliposomes with lipidated and non-lipidated peptide-dendrimeric scaffold for efficient transdermal delivery of a therapeutic agent: Development, characterization, toxicological and preclinical performance analyses

  Manikkath, J., Parekh, H. S. & Mutalik, S., 11-2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 156, p. 97-113 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Asenapine
  • Dendrimers
  • Toxicology
  • Peptides
  • Liposomes

• Synthesis, spectral characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff bases derived from 3-formyl quinoline and 2,6-diaminopyridine and their biological studies

  [Unknown], N., Dhumwad, S. D., Mutalik, S., Hugar, M. H. & Naik, P. N., 2013, In: Main Group Chemistry. 12, 1, p. 87-104 18 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Transdermal delivery of lercanidipine hydrochloride: Effect of chemical enhancers and ultrasound

  Shetty, P. K., Suthar, N. A., Menon, J., Deshpande, P. B., Avadhani, K., Kulkarni, R. V. & Mutalik, S., 2013, In: Current Drug Delivery. 10, 4, p. 427-434 8 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Two fold increase in synthesis of gold nanoparticles assisted by proteins and phenolic compounds in Pongamia seed cake extract: response surface methodology approach

  Nayak, S., Sajankila, S. P., Goveas, L. C., Rao, V. C., Mutalik, S. & Shreya, B. A., 04-2020, In: SN Applied Sciences. 2, 4, 634.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gold nanoparticles
  • phenolic compound
  • response surface methodology
  • Seed
  • Nanoparticles

• Viscosity and thermal conductivity of ZnO–water-based nanofluids stabilized by grafted SMA-g-MPEG comb-shaped copolymer for heat transfer applications

  Pavithra, K. S., Yashoda, M. P., Prasannakumar, S. & Mutalik, S., 01-02-2020, In: Iranian Polymer Journal (English Edition). 29, 2, p. 185-196 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Maleic Anhydrides
  • Styrene
  • Maleic anhydride
  • Polyethylene glycols
  • Copolymers
  2 Citations (Scopus)