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  In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells

  Mudgal, J., Shetty, P., Reddy, N. D., Akhila, H. S., Gourishetti, K., Mathew, G., Nayak, P. G., Kumar, N., Kishore, A., Kutty, N. G., Nandakumar, K., Shenoy, R. R., Rao, C. M. & Joseph, A., 14-10-2016, In: Frontiers in Pharmacology. 7, OCT, 381.

  Research output: Contribution to journal › Article › peer-review

  • N-acetyltalosaminuronic acid
  • p38 Mitogen-Activated Protein Kinases
  • Sucrose
  • Diet
  • Phosphorylation
  2 Citations (Scopus)

• Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

  Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In: International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitosan
  • Nanoparticles
  • Calcium
  • Rosuvastatin Calcium
  • Drugs
  19 Citations (Scopus)

• Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

  Kondamudi, P. K., Kovelamudi, H., Mathew, G., Nayak, P. G., Mallikarjuna Rao, C. & Shenoy, R. R., 2013, In: Pharmacological Reports. 65, 3, p. 658-665 8 p.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • Dinitrochlorobenzene
  • Sesamum
  • Sulfasalazine
  • Nitrites
  14 Citations (Scopus)

• N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats

  Fernandes, J., Mudgal, J., Rao, C. M., Arora, D., Basu Mallik, S., Pai, K. S. R. & Nampoothiri, M., 13-06-2018, In: Toxicology Mechanisms and Methods. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurokinin-1 Receptor Antagonists
  • Rats
  • Aluminum
  • Spatial Memory
  • Memory Disorders
  7 Citations (Scopus)

• Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

  Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In: Pharmacognosy Magazine. 14, 55, p. S197-S207

  Research output: Contribution to journal › Article › peer-review

  • naringin
  • Doxorubicin
  • Cognitive Dysfunction
  • naringenin
  • In Vitro Techniques
  2 Citations (Scopus)

• Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks

  Ramalingayya, G. V., Nampoothiri, M., Nayak, P. G., Kishore, A., Shenoy, R. R., Rao, C. M. & Nandakumar, K., 2016, In: Pharmacognosy Magazine. 12, 45, p. S63-S70

  Research output: Contribution to journal › Article › peer-review

  • naringin
  • Rutin
  • Episodic Memory
  • Memory Disorders
  • Recognition (Psychology)
  29 Citations (Scopus)

• Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

  Shenoy, R. R., Sudheendra, A. T., Nayak, P. G., Paul, P., Kutty, N. G. & Rao, C. M., 27-01-2011, In: Journal of Ethnopharmacology. 133, 2, p. 608-612 5 p.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • Sesamum
  • Wound Healing
  • Dexamethasone
  • Protein-Lysine 6-Oxidase
  35 Citations (Scopus)

• Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition

  Azeemuddin, M. M., Rao, C. M., Rafiq, M., Babu, U. V. & Rangesh, P., 01-10-2019, In: Experimental Gerontology. 125, 1 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid
  • Muscle
  • Locomotion
  • Pharmacology
  • Sarcopenia

• Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice

  Mudgal, J., Nampoothiri, M., Basu Mallik, S., Kinra, M., Hall, S., Grant, G., Anoopkumar-Dukie, S., Rao, C. M. & Arora, D., 01-10-2019, In: Inflammopharmacology. 27, 5, p. 941-948 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipopolysaccharides
  • Down-Regulation
  • Illness Behavior
  • Oxidative Stress
  • Anti-Inflammatory Agents
  8 Citations (Scopus)

• Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach

  Mudgal, J., Gowdra, V. S., Mudgal, P. P., Nayak, P. G., Kumar, N., Attari, Z., Rao, C. M. & Nampurath, G. K., 25-08-2016, In: European Journal of Pharmaceutical Sciences. 91, p. 74-83 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Arthritis
  • Experimental Arthritis
  • Dinoprostone
  • Cytokines
  • Inhibition (Psychology)
  3 Citations (Scopus)

• Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of xanthium strumarium in transplantable tumors in mice

  Aranjani, J. M., Manuel, A., Mallikarjuna Rao, C., Udupa, N., Rao, J. V., Joy, A. M., Gandhi, P. & Radhakrishnan, E. K., 2013, In: American Journal of Chinese Medicine. 41, 1, p. 145-162 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Xanthium
  • In Vitro Techniques
  • Neoplasms
  • Hexanes
  • Chloroform
  10 Citations (Scopus)

• Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer

  Kumar, N., Dhamija, I., Vasanth Raj, P., Jayashree, B. S., Parihar, V., Manjula, S. N., Thomas, S., Gopalan Kutty, N. & Mallikarjuna Rao, C., 2014, In: Arabian Journal of Chemistry. 7, 4, p. 409-417 9 p.

  Research output: Contribution to journal › Article › peer-review

  • carbostyril
  • Tumors
  • Derivatives
  • Liquids
  • Cytotoxicity
  18 Citations (Scopus)

• Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds

  Shenoy, R. R., Sudheendra, A. T., Nayak, P. G., Paul, P., Kutty, N. G. & Rao, C. M., 12-2011, In: Journal of Basic and Clinical Physiology and Pharmacology. 22, 4, p. 131-135 5 p.

  Research output: Contribution to journal › Article › peer-review

  • morin
  • Dexamethasone
  • Antioxidants
  • Wounds and Injuries
  • Granulation Tissue
  1 Citation (Scopus)

• Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride

  Jetti, R., Raghuveer, C. & Rao, M. C., 2016, In: Toxicology and Industrial Health. 32, 1, p. 183-187 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ginkgo biloba
  • Fluorides
  • Memory Disorders
  • Ascorbic Acid
  • Learning
  10 Citations (Scopus)

• Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation

  Mudgal, J., Gowdra, V. S., Mathew, G., Nayak, P. G., Reddy, N. D., Namdeo, N., Kumar, R. R., Kantamaneni, C., Chamallamudi, M. R. & Nampurath, G. K., 05-03-2014, In: Chemico-Biological Interactions. 210, 1, p. 34-42 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Carrageenan
  • Rats
  • Dinoprostone
  • Cytokines
  • Inflammation
  10 Citations (Scopus)

• Reversed-Phase HPLC Method for Determination of Temozolomide in Rat Plasma and Brain: Simple, Sensitive and Robust Method

  Attari, Z., Kumar, L., Mallikarjuna Rao, C. & Koteshwara, K. B., 01-06-2018, In: Pharmaceutical Chemistry Journal. 52, 3, p. 266-270 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • High Pressure Liquid Chromatography
  • Brain
  • Pharmaceutical Preparations
  • Temperature

• Role of the drug transporter ABCC3 in breast cancer chemoresistance

  Balaji, S. A., Udupa, N., Chamallamudi, M. R., Gupta, V. & Rangarajan, A., 01-05-2016, In: PLoS One. 11, 5, e0155013.

  Research output: Contribution to journal › Article › peer-review

  • breast neoplasms
  • Chemotherapy
  • transporters
  • drugs
  • Breast Neoplasms
  35 Citations (Scopus)

• Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents

  Kumar, J. S., Thirupataiah, B., Medishetti, R., Ray, A., Bele, S. D., Hossain, K. A., Reddy, G. S., Edwin, R. K., Joseph, A., Kumar, N., Shenoy, G. G., Rao, C. M. & Pal, M., 01-09-2020, In: European Journal of Medicinal Chemistry. 201, 112335.

  Research output: Contribution to journal › Article › peer-review

  • isocoumarin 3
  • Rosuvastatin Calcium
  • Cells
  • Antineoplastic Agents
  • Ultrasonics

• Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

  Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In: Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylnitrosourea
  • Rutin
  • Rats
  • Doxorubicin
  • Cognitive Dysfunction
  3 Citations (Scopus)

• Sambar, an Indian Dish Prevents the Development of Dimethyl Hydrazine-Induced Colon Cancer: A Preclinical Study

  Prasad, V. G., Reddy, N., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, M. C. & Shenoy, R., 07-2016, In: Pharmacognosy Magazine. 12, 47, p. S441-S445

  Research output: Contribution to journal › Article › peer-review

  • hydrazine
  • 1,2-Dimethylhydrazine
  • Colonic Neoplasms
  • Aberrant Crypt Foci
  • Spices
  5 Citations (Scopus)

• Selected novel 5’-amino-2’-hydroxy-1, 3-diaryl-2- propen-1-ones arrest cell cycle of HCT-116 in G₀/G₁ phase

  Simon, L., Srinivasan, K. K., Kumar, N., Reddy, N. D., Biswas, S., Mallikarjuna Rao, C. & Moorkoth, S., 13-01-2016, In: EXCLI Journal. 15, p. 21-32 12 p.

  Research output: Contribution to journal › Article › peer-review

  • cell cycle checkpoints
  • HCT116 Cells
  • Cell Cycle Resting Phase
  • G1 Phase
  • interphase
  4 Citations (Scopus)

• Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials

  Ghadge, G. A., Gourishetti, K., Chamallamudi, M. R., Nampurath, G. K., Nandakumar, K. & Kumar, N., 01-04-2020, In: 3 Biotech. 10, 4, 149.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • islets of Langerhans
  • Simvastatin
  • Mitochondrial Membrane Potential
  • Insulin-Secreting Cells
  1 Citation (Scopus)

• Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia

  Kumar, N., Mudgal, J., Parihar, V. K., Nayak, P. G., Kutty, N. G. & Rao, C. M., 06-2013, In: Lipids. 48, 6, p. 633-638 6 p.

  Research output: Contribution to journal › Article › peer-review

  • sesamolin
  • sesamol
  • Hyperlipidemias
  • tyloxapol
  • Plasmas
  24 Citations (Scopus)

• Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells

  Kumar, N., Rai, A., Reddy, N. D., Raj, P. V., Jain, P., Deshpande, P., Mathew, G., Kutty, N. G., Udupa, N. & Rao, C. M., 2014, In: Pharmacological Reports. 66, 5, p. 788-798 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Silybin
  • Silymarin
  • Liposomes
  • Biological Availability
  • Hepatocytes
  59 Citations (Scopus)

• Standardised extract of safed musli (Chlorophytum borivilianum) increases aphrodisiac potential besides being safe in male Wistar rats

  Das, S., Singhal, S., Kumar, N., Rao, C. M., Sumalatha, S., Dave, J., Dave, R. & Nandakumar, K., 01-12-2016, In: Andrologia. 48, 10, p. 1236-1243 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aphrodisiacs
  • Wistar Rats
  • Oligospermia
  • Glass
  • Sperm Count
  8 Citations (Scopus)

• Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-ones substituted with p-chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder

  Gowdra, V. S., Mudgal, J., Bansal, P., Nayak, P. G., Manohara Reddy, S. A., Shenoy, G. G., Valiathan, M., Chamallamudi, M. R. & Nampurath, G. K., 2014, In: BioMed Research International. 2014, 620434.

  Research output: Contribution to journal › Article › peer-review

  • Clofibric Acid
  • Acetic Acid
  • Insulin Resistance
  • Hypoadiponectinemia
  • Medical problems
  4 Citations (Scopus)

• Synthesis and evaluation of selected 1,3,4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity

  Tiwari, A., Gopalan Kutty, N., Kumar, N., Chaudhary, A., Vasanth Raj, P., Shenoy, R. & Mallikarjuna Rao, C., 01-12-2016, In: Cytotechnology. 68, 6, p. 2553-2565 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 1,3,4-oxadiazole
  • Cytotoxicity
  • Amikacin
  • Tumors
  • Cells
  9 Citations (Scopus)

• Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2,1,b]-benzothiazole derivatives

  Malik, J. K., Noolvi, M. N., Manvi, F. V., Nanjwade, B. K., Patel, H. M., Manjula, S. N., Mallikarjuna Rao, C. & Barve, A., 10-2011, In: Letters in Drug Design and Discovery. 8, 8, p. 717-724 8 p.

  Research output: Contribution to journal › Article › peer-review

  • benzothiazole
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Proton Magnetic Resonance Spectroscopy
  • MCF-7 Cells
  • Inhibitory Concentration 50
  4 Citations (Scopus)

• Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives

  Malik, J. K., Noolvi, M. N., Manvi, F. V., Nanjwade, B. K., Patel, H. M., Manjula, S. N., Rao, M. C. & Barve, A., 11-2011, In: Letters in Drug Design and Discovery. 8, 9, p. 717-724 8 p.

  Research output: Contribution to journal › Article › peer-review

  • benzothiazole
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Proton Magnetic Resonance Spectroscopy
  • MCF-7 Cells
  • Inhibitory Concentration 50

• The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure

  Raghu, J., Raghuveer, V. C., Rao, M. C., Somayaji, N. S. & Babu, P. B., 2013, In: Interdisciplinary Toxicology. 6, 4, p. 217-221 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ginkgo biloba
  • Fluorides
  • Memory Disorders
  • Ascorbic Acid
  • Learning
  8 Citations (Scopus)

• The enriched fraction of Vernonia cinerea L. Induces apoptosis and inhibits multi-drug resistance transporters in human epithelial cancer cells

  Appadath Beeran, A., Maliyakkal, N., Rao, C. M. & Udupa, N., 02-12-2014, In: Journal of Ethnopharmacology. PART A, p. 33-42 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Vernonia
  • Multiple Drug Resistance
  • Methylene Chloride
  • Epithelial Cells
  • Apoptosis
  7 Citations (Scopus)

• Validation of a sensitive and robust reversed phase-HPLC method for determination of temozolomide

  Attari, Z., Kumar, L., Rao, C. M. & Koteshwara, K. B., 2016, In: Latin American Journal of Pharmacy. 35, 5, p. 967-971 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • High Pressure Liquid Chromatography
  • formic acid
  • acetonitrile
  • Alkylating Agents
  2 Citations (Scopus)