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• 2019

  Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice

  Sahu, P., Mudgal, J., Arora, D., Kinra, M., Mallik, S. B., Rao, C. M., Pai, K. S. R. & Nampoothiri, M., 01-06-2019, In: Psychopharmacology. 236, 6, p. 1829-1838 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Illness Behavior
  • Cannabinoid Receptors
  • Lipopolysaccharides
  • Oxidative Stress
  • Tumor Necrosis Factor-alpha
  13 Citations (Scopus)

• Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

  Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In: Biomedical Reports. 11, 2, p. 79-84 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative stress
  • Catechin
  • Rats
  • Sprague Dawley Rats
  • Oxidative Stress
  11 Citations (Scopus)

• Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders

  Eapen, P. M., Rao, C. M. & Nampoothiri, M., 01-04-2019, In: Reviews in the Neurosciences. 30, 3, p. 233-243 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurokinin-1 Receptors
  • Nervous System Diseases
  • Substance P
  • Neurokinin-1 Receptor Antagonists
  • Drug Industry

• Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats

  Kinra, M., Arora, D., Mudgal, J., Pai, K. S. R., Mallikarjuna Rao, C. & Nampoothiri, M., 01-04-2019, In: Pharmacology. 103, 5-6, p. 315-319 5 p.

  Research output: Contribution to journal › Article › peer-review

  • caffeic acid
  • Acute Kidney Injury
  • Reperfusion
  • Ischemia
  • Celecoxib
  4 Citations (Scopus)

• Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats

  Kumar, N., Rai, A., Reddy, N. D., Shenoy, R. R., Mudgal, J., Bansal, P., Mudgal, P. P., Arumugam, K., Udupa, N., Sharma, N. & Rao, C. M., 01-08-2019, In: Pharmacological Reports. 71, 4, p. 703-712 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Silymarin
  • Liposomes
  • Wistar Rats
  • Alcohols
  • In Vitro Techniques
  1 Citation (Scopus)

• Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition

  Azeemuddin, M. M., Rao, C. M., Rafiq, M., Babu, U. V. & Rangesh, P., 01-10-2019, In: Experimental Gerontology. 125, 1 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid
  • Muscle
  • Locomotion
  • Pharmacology
  • Sarcopenia

• Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice

  Mudgal, J., Nampoothiri, M., Basu Mallik, S., Kinra, M., Hall, S., Grant, G., Anoopkumar-Dukie, S., Rao, C. M. & Arora, D., 01-10-2019, In: Inflammopharmacology. 27, 5, p. 941-948 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipopolysaccharides
  • Down-Regulation
  • Illness Behavior
  • Oxidative Stress
  • Anti-Inflammatory Agents
  10 Citations (Scopus)

• Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

  Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In: Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylnitrosourea
  • Rutin
  • Rats
  • Doxorubicin
  • Cognitive Dysfunction
  4 Citations (Scopus)
• 2018

  Catechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of wistar rats

  Saimithra, T., Kumar, N., Nandakumar, K., Nampoothiri, M. & Rao, C. M., 01-05-2018, In: Indian Journal of Experimental Biology. 56, 5, p. 314-321 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Catechin
  • Cachexia
  • Tea
  • Acetylcholine
  • Dexamethasone
  2 Citations (Scopus)

• Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

  Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In: Cytotechnology. p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxicity
  • Catechin
  • Rats
  • Episodic Memory
  • Memory Disorders
  25 Citations (Scopus)

• Chemically characterised extract of Saraca asoca improves the sexual function in male Wistar rats

  Gill, M., Rai, A., Kinra, M., Sumalatha, S., Rao, C. M., Cheruku, S. P., Devkar, R. & Kumar, N., 01-09-2018, In: Andrologia. 50, 7, e13037.

  Research output: Contribution to journal › Article › peer-review

  • Wistar Rats
  • Sexual Behavior
  • Spermatozoa
  • Aphrodisiacs
  • Sperm Count
  2 Citations (Scopus)

• Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

  Biswas, S. & Rao, C. M., 15-10-2018, In: European Journal of Pharmacology. 837, p. 8-24 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Epigenomics
  • Protein Domains
  • Neoplasms
  • Enzymes
  • Chromatin
  63 Citations (Scopus)

• Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model

  Gill, M., Kinra, M., Rai, A., Chamallamudi, M. R. & Kumar, N., 01-01-2018, In: NeuroReport. 29, 2, p. 134-140 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Antidepressive Agents
  • Antioxidants
  • Sucrose
  • Plant Bark
  • Cotyledon
  5 Citations (Scopus)

• Evaluation of novel 3-hydroxyflavone analogues as HDAC inhibitors against colorectal cancer

  Biswas, S., Reddy, N. D., Jayashree, B. S. & Rao, C. M., 01-01-2018, In: Advances in Pharmacological Sciences. 2018, 4751806.

  Research output: Contribution to journal › Article › peer-review

  • 3-hydroxyflavone
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Colorectal Neoplasms
  • Inhibitory Concentration 50
  4 Citations (Scopus)

• Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

  Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In: Journal of Ethnopharmacology. 210, p. 118-124 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tamarindus
  • Aphrodisiacs
  • Gas Chromatography-Mass Spectrometry
  • Saponins
  • Phenol
  13 Citations (Scopus)

• Heterocyclic homoprostanoid derivative attenuates monoarthritis in rats: An in vitro and in vivo preclinical paradigm

  Mudgal, J., Manohara Reddy, S. A., Mathew, G., Kishore, A., Mallikarjuna Rao, C. & Nampurath, G. K., 01-01-2018, In: European Journal of Pharmaceutical Sciences. 111, p. 320-329 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-6
  • Lipopolysaccharides
  • In Vitro Techniques
  • Prostaglandin-Endoperoxide Synthases
  • Reactive Oxygen Species
  1 Citation (Scopus)

• Interplay between adenosine receptor antagonist and cyclooxygenase inhibitor in haloperidol-induced extrapyramidal effects in mice

  Arora, D., Mudgal, J., Nampoothiri, M., Mallik, S. B., Kinra, M., Hall, S., Anoopkumar-Dukie, S., Grant, G. D. & Rao, C. M., 01-08-2018, In: Metabolic Brain Disease. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Purinergic P1 Receptor Antagonists
  • Cyclooxygenase Inhibitors
  • Haloperidol
  • Antipsychotic Agents
  • Caffeine
  2 Citations (Scopus)

• Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

  Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In: International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitosan
  • Nanoparticles
  • Calcium
  • Rosuvastatin Calcium
  • Drugs
  19 Citations (Scopus)

• N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats

  Fernandes, J., Mudgal, J., Rao, C. M., Arora, D., Basu Mallik, S., Pai, K. S. R. & Nampoothiri, M., 13-06-2018, In: Toxicology Mechanisms and Methods. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurokinin-1 Receptor Antagonists
  • Rats
  • Aluminum
  • Spatial Memory
  • Memory Disorders
  7 Citations (Scopus)

• Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

  Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In: Pharmacognosy Magazine. 14, 55, p. S197-S207

  Research output: Contribution to journal › Article › peer-review

  • naringin
  • Doxorubicin
  • Cognitive Dysfunction
  • naringenin
  • In Vitro Techniques
  2 Citations (Scopus)

• Reversed-Phase HPLC Method for Determination of Temozolomide in Rat Plasma and Brain: Simple, Sensitive and Robust Method

  Attari, Z., Kumar, L., Mallikarjuna Rao, C. & Koteshwara, K. B., 01-06-2018, In: Pharmaceutical Chemistry Journal. 52, 3, p. 266-270 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • High Pressure Liquid Chromatography
  • Brain
  • Pharmaceutical Preparations
  • Temperature
• 2017

  Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

  Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-05-2017, In: NeuroReport. 28, 9, p. 540-544 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Aluminum Chloride
  • Spatial Memory
  • Dementia
  • Insulin
  • Glucose
  12 Citations (Scopus)

• Epigenetics in cancer: Fundamentals and Beyond

  Biswas, S. & Rao, C. M., 01-05-2017, In: Pharmacology and Therapeutics. 173, p. 118-134 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Epigenomics
  • Neoplasms
  • Carcinogenesis
  • Nucleosomes
  • Gene Targeting
  91 Citations (Scopus)

• Evaluation of hepatoprotective effect of aqueous extract of Schrebera swietenioides bark against carbon tetrachloride-induced toxicity in wistar rats

  Kumar, N., Choudhary, A., Tiwari, A., Rasal, A., Jetti, R. & Mallikarjuna Rao, C., 01-03-2017, In: Advanced Science Letters. 23, 3, p. 1917-1920 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon tetrachloride
  • Liver
  • Toxicity
  • Carbon
  • Carbon Tetrachloride
  1 Citation (Scopus)

• Evaluation of in vitro and in vivo anticancer potential of two 5-acetamido chalcones against breast cancer

  Wankhede, S., Kumar, N., Simon, L., Biswas, S., Gourishetti, K., Ramalingayya, G. V., Joshi, M. & Rao, C. M., 19-10-2017, In: EXCLI Journal. 16, p. 1150-1163 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Chalcones
  • chalcones
  • breast neoplasms
  • Tumor Burden
  • neoplasms
  1 Citation (Scopus)

• Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats

  Nampoothiri, M., Ramalingayya, G. V., Kutty, N. G., Krishnadas, N. & Rao, C. M., 01-01-2017, In: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 36, 2, p. 159-169 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Aluminum Chloride
  • Spatial Learning
  • Rats
  • Spatial Memory
  • Dementia
  4 Citations (Scopus)

• In vitro and in vivo anticancer studies of 2′-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by hdac inhibition and cell cycle arrest

  Pande, A. N., Biswas, S., Reddy, N. D., Jayashree, B. S., Kumar, N. & Rao, C. M., 03-04-2017, In: EXCLI Journal. 16, p. 448-463 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Chalcone
  • chalcone
  • cell cycle checkpoints
  • colorectal neoplasms
  • Cell Cycle Checkpoints
  14 Citations (Scopus)

• Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

  Ramalingayya, G. V., Cheruku, S. P., Nayak, P. G., Kishore, A., Shenoy, R., Rao, M. & Krishnadas, N., 29-03-2017, In: Drug Design, Development and Therapy. 11, p. 1011-1026 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Rutin
  • Memory Disorders
  • Doxorubicin
  • Wistar Rats
  • In Vitro Techniques
  26 Citations (Scopus)

• Temozolomide and its stability—a critical factor

  Attari, Z., Rao, C. M., Kumar, L. & Koteshwara, K. B., 01-03-2017, In: Advanced Science Letters. 23, 3, p. 1841-1845 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Drugs
  • drug
  • Degradation
  • Pharmaceutical Preparations
  2 Citations (Scopus)
• 2014

  Curriculum for pharmacology in pharmacy institutions in India: Opportunities and challenges

  Goyal, R. K., Bhise, S. B., Srinivasan, B. P., Rao, C. M., Sen, T. & Koneri, R., 2014, In: Indian Journal of Pharmacology. 46, 3, p. 241-245 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Molecular Farming
  • Pharmacy
  • Curriculum
  • India
  • Pharmacology
  3 Citations (Scopus)

• Erratum: Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats

  Kondamudi, P. K., Kovelamudi, H., Mathew, G., Nayak, P. G., Rao, M. C. & Shenoy, R. R., 2014, In: The Scientific World Journal. 2014, 430734.

  Research output: Contribution to journal › Comment/debate › peer-review
  5 Citations (Scopus)

• Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer

  Prasad, V. G., Kawade, S., Jayashree, B. S., Reddy, N. D., Francis, A., Nayak, P. G., Kishore, A., Nandakumar, K., Rao, C. M. & Shenoy, R. R., 2014, In: BioMed Research International. 2014, 569130.

  Research output: Contribution to journal › Article › peer-review

  • Dimenhydrinate
  • Aberrant Crypt Foci
  • 1,2-Dimethylhydrazine
  • Colonic Neoplasms
  • N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
  8 Citations (Scopus)

• Influence of milk components in establishing biofilm mediated bacterial mastitis infections in cattle: A fractional factorial approach

  Atulya, M., Jesil Mathew, A., Venkata Rao, J. & Mallikarjuna Rao, C., 02-2014, In: Research in Veterinary Science. 96, 1, p. 25-27 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Mastitis
  • milk composition
  • biofilm
  • mastitis
  • Biofilms
  11 Citations (Scopus)

• Insulin blocks glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells

  Nampoothiri, M., Reddy, N. D., John, J., Kumar, N., Kutty Nampurath, G. & Rao Chamallamudi, M., 2014, In: Behavioural Neurology. 2014, 674164.

  Research output: Contribution to journal › Article › peer-review

  • Glutamic Acid
  • Insulin
  • Reactive Oxygen Species
  • Acridine Orange
  • Ethidium
  34 Citations (Scopus)

• Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats

  Kondamudi, P. K., Kovelamudi, H., Mathew, G., Nayak, P. G., Rao, M. C. & Shenoy, R. R., 2014, In: The Scientific World Journal. 2014, 673248.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • Rats
  • Acetic Acid
  • acetic acid
  • Peroxidase
  10 Citations (Scopus)

• Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer

  Kumar, N., Dhamija, I., Vasanth Raj, P., Jayashree, B. S., Parihar, V., Manjula, S. N., Thomas, S., Gopalan Kutty, N. & Mallikarjuna Rao, C., 2014, In: Arabian Journal of Chemistry. 7, 4, p. 409-417 9 p.

  Research output: Contribution to journal › Article › peer-review

  • carbostyril
  • Tumors
  • Derivatives
  • Liquids
  • Cytotoxicity
  18 Citations (Scopus)

• Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation

  Mudgal, J., Gowdra, V. S., Mathew, G., Nayak, P. G., Reddy, N. D., Namdeo, N., Kumar, R. R., Kantamaneni, C., Chamallamudi, M. R. & Nampurath, G. K., 05-03-2014, In: Chemico-Biological Interactions. 210, 1, p. 34-42 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Carrageenan
  • Rats
  • Dinoprostone
  • Cytokines
  • Inflammation
  10 Citations (Scopus)

• Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells

  Kumar, N., Rai, A., Reddy, N. D., Raj, P. V., Jain, P., Deshpande, P., Mathew, G., Kutty, N. G., Udupa, N. & Rao, C. M., 2014, In: Pharmacological Reports. 66, 5, p. 788-798 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Silybin
  • Silymarin
  • Liposomes
  • Biological Availability
  • Hepatocytes
  61 Citations (Scopus)

• Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-ones substituted with p-chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder

  Gowdra, V. S., Mudgal, J., Bansal, P., Nayak, P. G., Manohara Reddy, S. A., Shenoy, G. G., Valiathan, M., Chamallamudi, M. R. & Nampurath, G. K., 2014, In: BioMed Research International. 2014, 620434.

  Research output: Contribution to journal › Article › peer-review

  • Clofibric Acid
  • Acetic Acid
  • Insulin Resistance
  • Hypoadiponectinemia
  • Medical problems
  4 Citations (Scopus)

• The enriched fraction of Vernonia cinerea L. Induces apoptosis and inhibits multi-drug resistance transporters in human epithelial cancer cells

  Appadath Beeran, A., Maliyakkal, N., Rao, C. M. & Udupa, N., 02-12-2014, In: Journal of Ethnopharmacology. PART A, p. 33-42 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Vernonia
  • Multiple Drug Resistance
  • Methylene Chloride
  • Epithelial Cells
  • Apoptosis
  7 Citations (Scopus)
• 2012

  Acute and subacute toxicity of chloroform and hexaneextracts of root of Xanthium strumarium

  Aranjani, J. M., Rao, C. M., Manuel, A., Rao, J. V., Udupa, N. & Hebbar, K., 12-2012, In: Comparative Clinical Pathology. 21, 6, p. 1223-1230 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Xanthium
  • Chloroform
  • Hexanes
  • Toxic Plants
  • Mortality
  5 Citations (Scopus)

• Anticancer activity of Berberis aristata in Ehrlich ascites carcinoma-bearing mice: A preliminary study

  Pai, K. S. R., Srilatha, P., Suryakant, K., Setty, M. M., Nayak, P. G., Rao, C. M. & Baliga, M. S., 03-2012, In: Pharmaceutical Biology. 50, 3, p. 270-277 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Berberis
  • Ascites
  • Cisplatin
  • Artemia
  • Carcinoma
  11 Citations (Scopus)

• Elucidation of Structure-activity Relationship of 2-Quinolone Derivatives and Exploration of Their Antitumor Potential Through Bax-induced Apoptotic Pathway

  Kumar, N., Raj, V. P., Jayshree, B. S., Kar, S. S., Anandam, A., Thomas, S., Jain, P., Rai, A. & Rao, C. M., 08-2012, In: Chemical Biology and Drug Design. 80, 2, p. 291-299 9 p.

  Research output: Contribution to journal › Article › peer-review

  • carbostyril
  • Structure-Activity Relationship
  • Cells
  • Derivatives
  • Assays
  34 Citations (Scopus)

• Histological and physiochemical standardization of Melia azedarach. Linn bark

  Kumar, S. V., Sanghai, D. B., Rao, C. M. & Shreedhara, C. S., 01-2012, In: Asian Pacific Journal of Tropical Biomedicine. 2, 1 SUPPL.

  Research output: Contribution to journal › Article › peer-review

  • Melia azedarach
  • Sieves
  • Phloem
  • Standardization
  • Phytochemicals
  4 Citations (Scopus)