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• 2020

  An appraisal of current pharmacological perspectives of sesamol: A review

  Bosebabu, B., Cheruku, S. P., Chamallamudi, M. R., Nampoothiri, M., Shenoy, R. R., Nandakumar, K., Parihar, V. K. & Kumar, N., 2020, In: Mini-Reviews in Medicinal Chemistry. 20, 11, p. 988-1000 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • sesamol
  • Pharmacology
  • Sesamum
  • microbial metalloproteinases
  • Anti-Inflammatory Agents
  1 Citation (Scopus)

• A Review on Anticancer Potentials of Benzothiazole Derivatives

  Pathak, N., Rathi, E., Kumar, N., Kini, S. G. & Rao, C. M., 01-01-2020, In: Mini reviews in medicinal chemistry. 20, 1, p. 12-23 12 p.

  Research output: Contribution to journal › Article › peer-review

  • benzothiazole
  • Structure-Activity Relationship
  • Thiazoles
  • Cell Line
  • Neoplasms
  4 Citations (Scopus)

• Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study

  Rai, A., Gill, M., Kinra, M., Dsouza, L. A., Sumalatha, S., Raj, S., Shetty, R., Nandakumar, K., Chamallamudi, M. R. & Kumar, N., 01-11-2020, In: Andrologia.

  Research output: Contribution to journal › Article › peer-review

  • Catechin
  • Computer Simulation
  • Sildenafil Citrate
  • Spermatozoa
  • Testis

• Biologicals to direct nanotherapeutics towards HER2-positive breast cancers

  Kumar, G., Nandakumar, K., Mutalik, S. & Rao, C. M., 07-2020, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 27, 102197.

  Research output: Contribution to journal › Review article › peer-review

  • Biological Factors
  • Biological Products
  • Antineoplastic Combined Chemotherapy Protocols
  • Breast Neoplasms
  • Drug Compounding
  2 Citations (Scopus)

• Cinnamyl Sulfonamide Hydroxamate Derivatives Inhibited LPS-Stimulated NF-kB Expression in RAW 264.7 Cells in In Vitro and Mitigated Experimental Colitis in Wistar Rats in In Vivo

  Joshi, M., Reddy, N. D., Kumara, N., Sumalatha, S. & Rao, C. M., 24-06-2020, In: Current Pharmaceutical Design.

  Research output: Contribution to journal › Article › peer-review

  • RAW 264.7 Cells
  • Sulfonamides
  • NF-kappa B
  • Colitis
  • Lipopolysaccharides

• Corrigendum: Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress (Biomed Rep, (2019) 11, (79-84), 10.3892/br.2019.1226)

  Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 2020, In: Biomedical Reports. 13, 3, p. 1 1 p., 19.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Oxidative stress
  • Catechin
  • Rats
  • Catalase
  • Sprague Dawley Rats

• Dehydrozingerone protects temozolomide-induced cognitive impairment in normal and C6 glioma rats besides enhancing its anticancer potential

  Pathak, N., Cheruku, S. P., Rao, V., Vibhavari, R. J. A., Sumalatha, S., Gourishetti, K., Rao, C. M. & Kumar, N., 01-10-2020, In: 3 Biotech. 10, 10, 438.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methyl-3-methoxy-4-hydroxystyryl ketone
  • cognitive disorders
  • glioma
  • Temozolomide
  • Glioma

• Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice

  Mudgal, J., Basu Mallik, S., Nampoothiri, M., Kinra, M., Hall, S., Grant, G. D., Anoopkumar-Dukie, S., Davey, A. K., Rao, C. M. & Arora, D., 01-01-2020, In: Journal of Functional Foods. 103638.

  Research output: Contribution to journal › Article › peer-review

  • caffeic acid
  • Illness Behavior
  • Coffee
  • anxiety
  • caffeine
  3 Citations (Scopus)

• Evaluation of hepatoprotective effect of a polyherbal megakutki against paracetamol-induced hepatotoxicity

  Elizabeth Giri, A., Rao, V., Singhal, S., Gourishetti, K., Biswas, S., Nandakumar, K., Chamllamudi, M. R., Dave, J., Dave, R., Sumalatha, S. & Kumar, N., 01-10-2020, In: Indian Journal of Pharmaceutical Education and Research. 54, 4, p. 1080-1088 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acetaminophen
  • Silymarin
  • Inhibitory Concentration 50
  • In Vitro Techniques
  • DNA Fragmentation

• Radiotherapy and its impact on the nervous system of cancer survivors

  Kumar, G., Dutta, P., Parihar, V. K., Chamallamudi, M. R. & Kumar, N., 2020, In: CNS and Neurological Disorders - Drug Targets. 19, 5, p. 374-385 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cancer Survivors
  • Nervous System
  • Radiotherapy
  • Cognition
  • Search Engine

• Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents

  Kumar, J. S., Thirupataiah, B., Medishetti, R., Ray, A., Bele, S. D., Hossain, K. A., Reddy, G. S., Edwin, R. K., Joseph, A., Kumar, N., Shenoy, G. G., Rao, C. M. & Pal, M., 01-09-2020, In: European Journal of Medicinal Chemistry. 201, 112335.

  Research output: Contribution to journal › Article › peer-review

  • isocoumarin 3
  • Rosuvastatin Calcium
  • Cells
  • Antineoplastic Agents
  • Ultrasonics

• Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials

  Ghadge, G. A., Gourishetti, K., Chamallamudi, M. R., Nampurath, G. K., Nandakumar, K. & Kumar, N., 01-04-2020, In: 3 Biotech. 10, 4, 149.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • islets of Langerhans
  • Simvastatin
  • Mitochondrial Membrane Potential
  • Insulin-Secreting Cells
  1 Citation (Scopus)
• 2019

  Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice

  Sahu, P., Mudgal, J., Arora, D., Kinra, M., Mallik, S. B., Rao, C. M., Pai, K. S. R. & Nampoothiri, M., 01-06-2019, In: Psychopharmacology. 236, 6, p. 1829-1838 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Illness Behavior
  • Cannabinoid Receptors
  • Lipopolysaccharides
  • Oxidative Stress
  • Tumor Necrosis Factor-alpha
  10 Citations (Scopus)

• Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

  Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S. & Kumar, N., 01-01-2019, In: Biomedical Reports. 11, 2, p. 79-84 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative stress
  • Catechin
  • Rats
  • Sprague Dawley Rats
  • Oxidative Stress
  8 Citations (Scopus)

• Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders

  Eapen, P. M., Rao, C. M. & Nampoothiri, M., 01-04-2019, In: Reviews in the Neurosciences. 30, 3, p. 233-243 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurokinin-1 Receptors
  • Nervous System Diseases
  • Substance P
  • Neurokinin-1 Receptor Antagonists
  • Drug Industry

• Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats

  Kinra, M., Arora, D., Mudgal, J., Pai, K. S. R., Mallikarjuna Rao, C. & Nampoothiri, M., 01-04-2019, In: Pharmacology. 103, 5-6, p. 315-319 5 p.

  Research output: Contribution to journal › Article › peer-review

  • caffeic acid
  • Acute Kidney Injury
  • Reperfusion
  • Ischemia
  • Celecoxib
  4 Citations (Scopus)

• Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats

  Kumar, N., Rai, A., Reddy, N. D., Shenoy, R. R., Mudgal, J., Bansal, P., Mudgal, P. P., Arumugam, K., Udupa, N., Sharma, N. & Rao, C. M., 01-08-2019, In: Pharmacological Reports. 71, 4, p. 703-712 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Silymarin
  • Liposomes
  • Wistar Rats
  • Alcohols
  • In Vitro Techniques
  1 Citation (Scopus)

• Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition

  Azeemuddin, M. M., Rao, C. M., Rafiq, M., Babu, U. V. & Rangesh, P., 01-10-2019, In: Experimental Gerontology. 125, 1 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid
  • Muscle
  • Locomotion
  • Pharmacology
  • Sarcopenia

• Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice

  Mudgal, J., Nampoothiri, M., Basu Mallik, S., Kinra, M., Hall, S., Grant, G., Anoopkumar-Dukie, S., Rao, C. M. & Arora, D., 01-10-2019, In: Inflammopharmacology. 27, 5, p. 941-948 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipopolysaccharides
  • Down-Regulation
  • Illness Behavior
  • Oxidative Stress
  • Anti-Inflammatory Agents
  9 Citations (Scopus)

• Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma

  Ramalingayya, G. V., Gourishetti, K., Nayak, P. G., Mallikarjuna Rao, C., Kishore, A., Alnaseer, S. M., Hussain, S. M. & Nandakumar, K., 01-01-2019, In: Journal of Environmental Pathology, Toxicology and Oncology. 38, 2, p. 153-163 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylnitrosourea
  • Rutin
  • Rats
  • Doxorubicin
  • Cognitive Dysfunction
  3 Citations (Scopus)
• 2018

  Catechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of wistar rats

  Saimithra, T., Kumar, N., Nandakumar, K., Nampoothiri, M. & Rao, C. M., 01-05-2018, In: Indian Journal of Experimental Biology. 56, 5, p. 314-321 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Catechin
  • Cachexia
  • Tea
  • Acetylcholine
  • Dexamethasone
  2 Citations (Scopus)

• Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

  Cheruku, S. P., Ramalingayya, G. V., Rao, M. C., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K. & Kumar, N., 01-02-2018, In: Cytotechnology. p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxicity
  • Catechin
  • Rats
  • Episodic Memory
  • Memory Disorders
  24 Citations (Scopus)

• Chemically characterised extract of Saraca asoca improves the sexual function in male Wistar rats

  Gill, M., Rai, A., Kinra, M., Sumalatha, S., Rao, C. M., Cheruku, S. P., Devkar, R. & Kumar, N., 01-09-2018, In: Andrologia. 50, 7, e13037.

  Research output: Contribution to journal › Article › peer-review

  • Wistar Rats
  • Sexual Behavior
  • Spermatozoa
  • Aphrodisiacs
  • Sperm Count
  2 Citations (Scopus)

• Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

  Biswas, S. & Rao, C. M., 15-10-2018, In: European Journal of Pharmacology. 837, p. 8-24 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Epigenomics
  • Protein Domains
  • Neoplasms
  • Enzymes
  • Chromatin
  57 Citations (Scopus)

• Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model

  Gill, M., Kinra, M., Rai, A., Chamallamudi, M. R. & Kumar, N., 01-01-2018, In: NeuroReport. 29, 2, p. 134-140 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Antidepressive Agents
  • Antioxidants
  • Sucrose
  • Plant Bark
  • Cotyledon
  5 Citations (Scopus)

• Evaluation of novel 3-hydroxyflavone analogues as HDAC inhibitors against colorectal cancer

  Biswas, S., Reddy, N. D., Jayashree, B. S. & Rao, C. M., 01-01-2018, In: Advances in Pharmacological Sciences. 2018, 4751806.

  Research output: Contribution to journal › Article › peer-review

  • 3-hydroxyflavone
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Colorectal Neoplasms
  • Inhibitory Concentration 50
  4 Citations (Scopus)

• Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp

  Rai, A., Das, S., Chamallamudi, M. R., Nandakumar, K., Shetty, R., Gill, M., Sumalatha, S., Devkar, R., Gourishetti, K. & Kumar, N., 10-01-2018, In: Journal of Ethnopharmacology. 210, p. 118-124 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tamarindus
  • Aphrodisiacs
  • Gas Chromatography-Mass Spectrometry
  • Saponins
  • Phenol
  12 Citations (Scopus)

• Heterocyclic homoprostanoid derivative attenuates monoarthritis in rats: An in vitro and in vivo preclinical paradigm

  Mudgal, J., Manohara Reddy, S. A., Mathew, G., Kishore, A., Mallikarjuna Rao, C. & Nampurath, G. K., 01-01-2018, In: European Journal of Pharmaceutical Sciences. 111, p. 320-329 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-6
  • Lipopolysaccharides
  • In Vitro Techniques
  • Prostaglandin-Endoperoxide Synthases
  • Reactive Oxygen Species
  1 Citation (Scopus)

• Interplay between adenosine receptor antagonist and cyclooxygenase inhibitor in haloperidol-induced extrapyramidal effects in mice

  Arora, D., Mudgal, J., Nampoothiri, M., Mallik, S. B., Kinra, M., Hall, S., Anoopkumar-Dukie, S., Grant, G. D. & Rao, C. M., 01-08-2018, In: Metabolic Brain Disease. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Purinergic P1 Receptor Antagonists
  • Cyclooxygenase Inhibitors
  • Haloperidol
  • Antipsychotic Agents
  • Caffeine
  2 Citations (Scopus)

• Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

  Hirpara, M. R., Manikkath, J., Sivakumar, K., Managuli, R. S., Gourishetti, K., Krishnadas, N., Shenoy, R. R., Jayaprakash, B., Rao, C. M. & Mutalik, S., 01-02-2018, In: International Journal of Biological Macromolecules. 107, p. 2190-2200 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitosan
  • Nanoparticles
  • Calcium
  • Rosuvastatin Calcium
  • Drugs
  19 Citations (Scopus)

• N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats

  Fernandes, J., Mudgal, J., Rao, C. M., Arora, D., Basu Mallik, S., Pai, K. S. R. & Nampoothiri, M., 13-06-2018, In: Toxicology Mechanisms and Methods. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurokinin-1 Receptor Antagonists
  • Rats
  • Aluminum
  • Spatial Memory
  • Memory Disorders
  7 Citations (Scopus)

• Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo

  Ramalingayya, G. V., Nayak, P. G., Shenoy, R. R., Mallik, S. B., Gourishetti, K., Hussain, S. M., Rao, C. M. & Nandakumar, K., 01-04-2018, In: Pharmacognosy Magazine. 14, 55, p. S197-S207

  Research output: Contribution to journal › Article › peer-review

  • naringin
  • Doxorubicin
  • Cognitive Dysfunction
  • naringenin
  • In Vitro Techniques
  2 Citations (Scopus)

• Reversed-Phase HPLC Method for Determination of Temozolomide in Rat Plasma and Brain: Simple, Sensitive and Robust Method

  Attari, Z., Kumar, L., Mallikarjuna Rao, C. & Koteshwara, K. B., 01-06-2018, In: Pharmaceutical Chemistry Journal. 52, 3, p. 266-270 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • High Pressure Liquid Chromatography
  • Brain
  • Pharmaceutical Preparations
  • Temperature
• 2013

  Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats

  Vijaya Kumar, S., Sanghai, D. B., Mallikarjuna Rao, C. & Shreedhara, C. S., 2013, In: Research Journal of Pharmacy and Technology. 6, 11, p. 1195-1199 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Melia azedarach
  • Hypolipidemic Agents
  • ethyl acetate
  • Antioxidants
  • Flavonoids
  2 Citations (Scopus)

• A rat model against chemotherapy plus radiation-induced oral mucositis

  Patel, A., Rajesh, S., Chandrashekhar, V. M., Rathnam, S., Shah, K., Mallikarjuna Rao, C. & Nandakumar, K., 10-2013, In: Saudi Pharmaceutical Journal. 21, 4, p. 399-403 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Stomatitis
  • Radiation
  • Mucositis
  • Drug Therapy
  • Tongue
  3 Citations (Scopus)

• A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of its in vitro and in vivo cytotoxic potential through liposomal formulation

  Jain, P., Kumar, N., Josyula, V. R., Jagani, H. V., Udupa, N., Mallikarjuna Rao, C. & Vasanth Raj, P., 2013, In: European Journal of Pharmaceutical Sciences. 50, 3-4, p. 353-365 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Catechin
  • Caspases
  • Hep G2 Cells
  • In Vitro Techniques
  • Liposomes
  24 Citations (Scopus)

• Impact of caffeic acid on aluminium chloride-induced dementia in rats

  Khan, K. A., Kumar, N., Nayak, P. G., Nampoothiri, M., Shenoy, R. R., Krishnadas, N., Rao, C. M. & Mudgal, J., 12-2013, In: Journal of Pharmacy and Pharmacology. 65, 12, p. 1745-1752 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aluminum Chloride
  • caffeic acid
  • Dementia
  • Acetylcholinesterase
  • Nitrites
  42 Citations (Scopus)

• In vitro and in vivo evaluation of the efficacy of nanoformulation of siRNA as an adjuvant to improve the anticancer potential of cisplatin

  Koganti, S., Jagani, H. V., Palanimuthu, V. R., Mathew, J. A., Rao, M. C. & Rao, J. V., 02-2013, In: Experimental and Molecular Pathology. 94, 1, p. 137-147 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cisplatin
  • Small Interfering RNA
  • In Vitro Techniques
  • Tumors
  • Genes
  14 Citations (Scopus)

• Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

  Kondamudi, P. K., Kovelamudi, H., Mathew, G., Nayak, P. G., Mallikarjuna Rao, C. & Shenoy, R. R., 2013, In: Pharmacological Reports. 65, 3, p. 658-665 8 p.

  Research output: Contribution to journal › Article › peer-review

  • sesamol
  • Dinitrochlorobenzene
  • Sesamum
  • Sulfasalazine
  • Nitrites
  14 Citations (Scopus)

• Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of xanthium strumarium in transplantable tumors in mice

  Aranjani, J. M., Manuel, A., Mallikarjuna Rao, C., Udupa, N., Rao, J. V., Joy, A. M., Gandhi, P. & Radhakrishnan, E. K., 2013, In: American Journal of Chinese Medicine. 41, 1, p. 145-162 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Xanthium
  • In Vitro Techniques
  • Neoplasms
  • Hexanes
  • Chloroform
  10 Citations (Scopus)

• Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia

  Kumar, N., Mudgal, J., Parihar, V. K., Nayak, P. G., Kutty, N. G. & Rao, C. M., 06-2013, In: Lipids. 48, 6, p. 633-638 6 p.

  Research output: Contribution to journal › Article › peer-review

  • sesamolin
  • sesamol
  • Hyperlipidemias
  • tyloxapol
  • Plasmas
  24 Citations (Scopus)

• The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure

  Raghu, J., Raghuveer, V. C., Rao, M. C., Somayaji, N. S. & Babu, P. B., 2013, In: Interdisciplinary Toxicology. 6, 4, p. 217-221 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ginkgo biloba
  • Fluorides
  • Memory Disorders
  • Ascorbic Acid
  • Learning
  8 Citations (Scopus)