A clinical study of patients with idiopathic thrombocytopenic purpura

Karthik Rao, N. Gurukanth Rao, Navin Patil, O. Balaji, N. R. Rao, Jayaprakash Rao, Satish Nayak

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to analyze the incidence, age and sex distribution among adults, various modes of presentation, correlation between thrombocytopenia and bleeding manifestations, and various modalities of treatment of ITP in a tertiary care hospital in India. Methods: A prospective study included 40 cases of ITP admitted to Kasturba Medical College Hospital, Manipal, from November 2005 to March 2007. Patients above 14 years of age admitted with thrombocytopenia in this institution were screened based on detailed clinical history, physical examination, and laboratory investigations. Results: The maximum incidence was in the 3rd decade of life accounting for 27.5% of the patients. Male-to–female ratio was 1:1.9 with female preponderance. Females in the 3rd decade had maximum incidence while males in the 4th decade have maximum incidence. The majority (12, 85.71%) of male patients and 15 (57.69%) female patients developed purpura during the course of disease. The mean count was 17.8×109/L with range between 2.0×109/L and 76×109/L. Cutaneous bleeding spots were found to be associated with counts above 25000×109/L and hematuria with lowest counts around 4000×109/L. A number of 20 (50%) of the above 40 patients responded to corticosteroids alone and did not have any further relapse. Among the remaining patients, 3 (7.5%) had a relapse of symptoms within next 6 months and responded to repeat prednisolone started at 1 mg/kg. 2 (5%) patients were given steroids tapering dose with IV immune globulins for initial 5 days as therapy to which they responded. Conclusion: Idiopathic thrombocytopenia is 1.9 times more common in females than males. Most common presentation is bleeding spots over body. Bleeding manifestations are more common with thrombocytopenia <30000/mm3. Corticosteroids are the mainstay in treatment. Complete remission is seen in up to 57.5% of the patients. Splenectomy is the second modality of treatment in ITP. Complete and sustained remission is seen 75% of patients.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number7
DOIs
Publication statusPublished - 01-01-2017

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Idiopathic Thrombocytopenic Purpura
Inosine Triphosphate
Thrombocytopenia
Hemorrhage
Incidence
Adrenal Cortex Hormones
Clinical Studies
Recurrence
Sex Distribution
Purpura
Age Distribution
Hematuria
Splenectomy
Tertiary Healthcare
Therapeutics
Prednisolone
Tertiary Care Centers
Physical Examination
Immunoglobulins
India

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Rao, Karthik ; Gurukanth Rao, N. ; Patil, Navin ; Balaji, O. ; Rao, N. R. ; Rao, Jayaprakash ; Nayak, Satish. / A clinical study of patients with idiopathic thrombocytopenic purpura. In: Asian Journal of Pharmaceutical and Clinical Research. 2017 ; Vol. 10, No. 7. pp. 373-377.
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abstract = "Objective: The aim of this study was to analyze the incidence, age and sex distribution among adults, various modes of presentation, correlation between thrombocytopenia and bleeding manifestations, and various modalities of treatment of ITP in a tertiary care hospital in India. Methods: A prospective study included 40 cases of ITP admitted to Kasturba Medical College Hospital, Manipal, from November 2005 to March 2007. Patients above 14 years of age admitted with thrombocytopenia in this institution were screened based on detailed clinical history, physical examination, and laboratory investigations. Results: The maximum incidence was in the 3rd decade of life accounting for 27.5{\%} of the patients. Male-to–female ratio was 1:1.9 with female preponderance. Females in the 3rd decade had maximum incidence while males in the 4th decade have maximum incidence. The majority (12, 85.71{\%}) of male patients and 15 (57.69{\%}) female patients developed purpura during the course of disease. The mean count was 17.8×109/L with range between 2.0×109/L and 76×109/L. Cutaneous bleeding spots were found to be associated with counts above 25000×109/L and hematuria with lowest counts around 4000×109/L. A number of 20 (50{\%}) of the above 40 patients responded to corticosteroids alone and did not have any further relapse. Among the remaining patients, 3 (7.5{\%}) had a relapse of symptoms within next 6 months and responded to repeat prednisolone started at 1 mg/kg. 2 (5{\%}) patients were given steroids tapering dose with IV immune globulins for initial 5 days as therapy to which they responded. Conclusion: Idiopathic thrombocytopenia is 1.9 times more common in females than males. Most common presentation is bleeding spots over body. Bleeding manifestations are more common with thrombocytopenia <30000/mm3. Corticosteroids are the mainstay in treatment. Complete remission is seen in up to 57.5{\%} of the patients. Splenectomy is the second modality of treatment in ITP. Complete and sustained remission is seen 75{\%} of patients.",
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A clinical study of patients with idiopathic thrombocytopenic purpura. / Rao, Karthik; Gurukanth Rao, N.; Patil, Navin; Balaji, O.; Rao, N. R.; Rao, Jayaprakash; Nayak, Satish.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 7, 01.01.2017, p. 373-377.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A clinical study of patients with idiopathic thrombocytopenic purpura

AU - Rao, Karthik

AU - Gurukanth Rao, N.

AU - Patil, Navin

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AU - Rao, N. R.

AU - Rao, Jayaprakash

AU - Nayak, Satish

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N2 - Objective: The aim of this study was to analyze the incidence, age and sex distribution among adults, various modes of presentation, correlation between thrombocytopenia and bleeding manifestations, and various modalities of treatment of ITP in a tertiary care hospital in India. Methods: A prospective study included 40 cases of ITP admitted to Kasturba Medical College Hospital, Manipal, from November 2005 to March 2007. Patients above 14 years of age admitted with thrombocytopenia in this institution were screened based on detailed clinical history, physical examination, and laboratory investigations. Results: The maximum incidence was in the 3rd decade of life accounting for 27.5% of the patients. Male-to–female ratio was 1:1.9 with female preponderance. Females in the 3rd decade had maximum incidence while males in the 4th decade have maximum incidence. The majority (12, 85.71%) of male patients and 15 (57.69%) female patients developed purpura during the course of disease. The mean count was 17.8×109/L with range between 2.0×109/L and 76×109/L. Cutaneous bleeding spots were found to be associated with counts above 25000×109/L and hematuria with lowest counts around 4000×109/L. A number of 20 (50%) of the above 40 patients responded to corticosteroids alone and did not have any further relapse. Among the remaining patients, 3 (7.5%) had a relapse of symptoms within next 6 months and responded to repeat prednisolone started at 1 mg/kg. 2 (5%) patients were given steroids tapering dose with IV immune globulins for initial 5 days as therapy to which they responded. Conclusion: Idiopathic thrombocytopenia is 1.9 times more common in females than males. Most common presentation is bleeding spots over body. Bleeding manifestations are more common with thrombocytopenia <30000/mm3. Corticosteroids are the mainstay in treatment. Complete remission is seen in up to 57.5% of the patients. Splenectomy is the second modality of treatment in ITP. Complete and sustained remission is seen 75% of patients.

AB - Objective: The aim of this study was to analyze the incidence, age and sex distribution among adults, various modes of presentation, correlation between thrombocytopenia and bleeding manifestations, and various modalities of treatment of ITP in a tertiary care hospital in India. Methods: A prospective study included 40 cases of ITP admitted to Kasturba Medical College Hospital, Manipal, from November 2005 to March 2007. Patients above 14 years of age admitted with thrombocytopenia in this institution were screened based on detailed clinical history, physical examination, and laboratory investigations. Results: The maximum incidence was in the 3rd decade of life accounting for 27.5% of the patients. Male-to–female ratio was 1:1.9 with female preponderance. Females in the 3rd decade had maximum incidence while males in the 4th decade have maximum incidence. The majority (12, 85.71%) of male patients and 15 (57.69%) female patients developed purpura during the course of disease. The mean count was 17.8×109/L with range between 2.0×109/L and 76×109/L. Cutaneous bleeding spots were found to be associated with counts above 25000×109/L and hematuria with lowest counts around 4000×109/L. A number of 20 (50%) of the above 40 patients responded to corticosteroids alone and did not have any further relapse. Among the remaining patients, 3 (7.5%) had a relapse of symptoms within next 6 months and responded to repeat prednisolone started at 1 mg/kg. 2 (5%) patients were given steroids tapering dose with IV immune globulins for initial 5 days as therapy to which they responded. Conclusion: Idiopathic thrombocytopenia is 1.9 times more common in females than males. Most common presentation is bleeding spots over body. Bleeding manifestations are more common with thrombocytopenia <30000/mm3. Corticosteroids are the mainstay in treatment. Complete remission is seen in up to 57.5% of the patients. Splenectomy is the second modality of treatment in ITP. Complete and sustained remission is seen 75% of patients.

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