A clinicohaematologic comparison of adult Chronic Myeloid Leukaemia and Juvenile Myelomonocytic Leukaemia in young patients

S. Mohan, Chethan Manohar, M. Mathew, A. Kurien, S. Mehta

Research output: Contribution to journalArticle

Abstract

Chronic Myeloid Leukaemia (CML) is rare in young patients. Out of 93 cases diagnosed as CML, 11 patients were under the age of twenty years (11.8%). Nine of them showed typical features of ACML while two children less than 6 years old showed features of JMML. This study compares the two groups of patients in terms of clinical features, peripheral blood and bone marrow findings. Patients with ACML had a mean age of 10.5 years against the mean of 4 years for JMML patients. ACML showed a female predominance while both patients of JMML were male children. patients in both groups presented with organomegaly but JMML patients exhibited a more aggressive clinical course and expired two and ten months after diagnosis. The peripheral blood showed an elevated WBC count in both groups. The platelet count was normal in most patients of ACML while it was reduced in one and increased in the second patient of JMML. The diagnosis of JMML was based on the findings of absolute monocytosis, reduced or absent megakaryocytes and absence of micromegakaryocytes.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalIndian Journal of Hematology and Blood Transfusion
Volume20
Issue number1
Publication statusPublished - 01-03-2002

Fingerprint

Juvenile Myelomonocytic Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Megakaryocytes
Platelet Count

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

@article{95b8f70a39884f07b4260aae2ba27f9a,
title = "A clinicohaematologic comparison of adult Chronic Myeloid Leukaemia and Juvenile Myelomonocytic Leukaemia in young patients",
abstract = "Chronic Myeloid Leukaemia (CML) is rare in young patients. Out of 93 cases diagnosed as CML, 11 patients were under the age of twenty years (11.8{\%}). Nine of them showed typical features of ACML while two children less than 6 years old showed features of JMML. This study compares the two groups of patients in terms of clinical features, peripheral blood and bone marrow findings. Patients with ACML had a mean age of 10.5 years against the mean of 4 years for JMML patients. ACML showed a female predominance while both patients of JMML were male children. patients in both groups presented with organomegaly but JMML patients exhibited a more aggressive clinical course and expired two and ten months after diagnosis. The peripheral blood showed an elevated WBC count in both groups. The platelet count was normal in most patients of ACML while it was reduced in one and increased in the second patient of JMML. The diagnosis of JMML was based on the findings of absolute monocytosis, reduced or absent megakaryocytes and absence of micromegakaryocytes.",
author = "S. Mohan and Chethan Manohar and M. Mathew and A. Kurien and S. Mehta",
year = "2002",
month = "3",
day = "1",
language = "English",
volume = "20",
pages = "19--21",
journal = "Indian Journal of Hematology and Blood Transfusion",
issn = "0971-4502",
publisher = "Springer India",
number = "1",

}

A clinicohaematologic comparison of adult Chronic Myeloid Leukaemia and Juvenile Myelomonocytic Leukaemia in young patients. / Mohan, S.; Manohar, Chethan; Mathew, M.; Kurien, A.; Mehta, S.

In: Indian Journal of Hematology and Blood Transfusion, Vol. 20, No. 1, 01.03.2002, p. 19-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A clinicohaematologic comparison of adult Chronic Myeloid Leukaemia and Juvenile Myelomonocytic Leukaemia in young patients

AU - Mohan, S.

AU - Manohar, Chethan

AU - Mathew, M.

AU - Kurien, A.

AU - Mehta, S.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Chronic Myeloid Leukaemia (CML) is rare in young patients. Out of 93 cases diagnosed as CML, 11 patients were under the age of twenty years (11.8%). Nine of them showed typical features of ACML while two children less than 6 years old showed features of JMML. This study compares the two groups of patients in terms of clinical features, peripheral blood and bone marrow findings. Patients with ACML had a mean age of 10.5 years against the mean of 4 years for JMML patients. ACML showed a female predominance while both patients of JMML were male children. patients in both groups presented with organomegaly but JMML patients exhibited a more aggressive clinical course and expired two and ten months after diagnosis. The peripheral blood showed an elevated WBC count in both groups. The platelet count was normal in most patients of ACML while it was reduced in one and increased in the second patient of JMML. The diagnosis of JMML was based on the findings of absolute monocytosis, reduced or absent megakaryocytes and absence of micromegakaryocytes.

AB - Chronic Myeloid Leukaemia (CML) is rare in young patients. Out of 93 cases diagnosed as CML, 11 patients were under the age of twenty years (11.8%). Nine of them showed typical features of ACML while two children less than 6 years old showed features of JMML. This study compares the two groups of patients in terms of clinical features, peripheral blood and bone marrow findings. Patients with ACML had a mean age of 10.5 years against the mean of 4 years for JMML patients. ACML showed a female predominance while both patients of JMML were male children. patients in both groups presented with organomegaly but JMML patients exhibited a more aggressive clinical course and expired two and ten months after diagnosis. The peripheral blood showed an elevated WBC count in both groups. The platelet count was normal in most patients of ACML while it was reduced in one and increased in the second patient of JMML. The diagnosis of JMML was based on the findings of absolute monocytosis, reduced or absent megakaryocytes and absence of micromegakaryocytes.

UR - http://www.scopus.com/inward/record.url?scp=0036521266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036521266&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 19

EP - 21

JO - Indian Journal of Hematology and Blood Transfusion

JF - Indian Journal of Hematology and Blood Transfusion

SN - 0971-4502

IS - 1

ER -