A comparative assessment of the ADR profile in various anti-cancer regimens excluding gastro-intestinal and haematological toxicity at a tertiary care centre

M. K. Vijayalaxmi, Princy Louis Palatty, Parvathi Bhat, M. Dinesh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study compared the adverse drug reaction (ADR) profile in various anti-cancer regimens in 55 patients who attended a tertiary care centre. The adverse drug reactions which are caused by anticancer agents are common and they may be enhanced when the drugs are used in combinations. The cases which conformed to the inclusion criteriae were selected and the details were noted in a proforma, which were then statistically analyzed. The results which were obtained, showed that the ADRs were common, but that they occurred in a similar frequency as in other study groups and that the severity grade was low. The counter measures to tackle the adverse reactions were also effective, leading to a hundred percent survival through the six cycles and the two year survival, which in itself spoke volumes about the ADRs. These findings were in tune with the findings of various researchers in the field of anti cancer toxicity profiles. The incidence of the neurotoxicity, the dermatological adverse effects and other miscellaneous ADRs was frequent, but not of high severity.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalJournal of Clinical and Diagnostic Research
Volume5
Issue number6
Publication statusPublished - 05-06-2012
Externally publishedYes

Fingerprint

Drug-Related Side Effects and Adverse Reactions
Tertiary Care Centers
Toxicity
Survival
Pharmaceutical Preparations
Antineoplastic Agents
Neoplasms
Research Personnel
Incidence

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

@article{b8010953725b43eb8b54a1df7a478a01,
title = "A comparative assessment of the ADR profile in various anti-cancer regimens excluding gastro-intestinal and haematological toxicity at a tertiary care centre",
abstract = "This study compared the adverse drug reaction (ADR) profile in various anti-cancer regimens in 55 patients who attended a tertiary care centre. The adverse drug reactions which are caused by anticancer agents are common and they may be enhanced when the drugs are used in combinations. The cases which conformed to the inclusion criteriae were selected and the details were noted in a proforma, which were then statistically analyzed. The results which were obtained, showed that the ADRs were common, but that they occurred in a similar frequency as in other study groups and that the severity grade was low. The counter measures to tackle the adverse reactions were also effective, leading to a hundred percent survival through the six cycles and the two year survival, which in itself spoke volumes about the ADRs. These findings were in tune with the findings of various researchers in the field of anti cancer toxicity profiles. The incidence of the neurotoxicity, the dermatological adverse effects and other miscellaneous ADRs was frequent, but not of high severity.",
author = "Vijayalaxmi, {M. K.} and Palatty, {Princy Louis} and Parvathi Bhat and M. Dinesh",
year = "2012",
month = "6",
day = "5",
language = "English",
volume = "5",
pages = "1209--1213",
journal = "Journal of Clinical and Diagnostic Research",
issn = "2249-782X",
publisher = "Journal of Clinical and Diagnostic Research",
number = "6",

}

A comparative assessment of the ADR profile in various anti-cancer regimens excluding gastro-intestinal and haematological toxicity at a tertiary care centre. / Vijayalaxmi, M. K.; Palatty, Princy Louis; Bhat, Parvathi; Dinesh, M.

In: Journal of Clinical and Diagnostic Research, Vol. 5, No. 6, 05.06.2012, p. 1209-1213.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A comparative assessment of the ADR profile in various anti-cancer regimens excluding gastro-intestinal and haematological toxicity at a tertiary care centre

AU - Vijayalaxmi, M. K.

AU - Palatty, Princy Louis

AU - Bhat, Parvathi

AU - Dinesh, M.

PY - 2012/6/5

Y1 - 2012/6/5

N2 - This study compared the adverse drug reaction (ADR) profile in various anti-cancer regimens in 55 patients who attended a tertiary care centre. The adverse drug reactions which are caused by anticancer agents are common and they may be enhanced when the drugs are used in combinations. The cases which conformed to the inclusion criteriae were selected and the details were noted in a proforma, which were then statistically analyzed. The results which were obtained, showed that the ADRs were common, but that they occurred in a similar frequency as in other study groups and that the severity grade was low. The counter measures to tackle the adverse reactions were also effective, leading to a hundred percent survival through the six cycles and the two year survival, which in itself spoke volumes about the ADRs. These findings were in tune with the findings of various researchers in the field of anti cancer toxicity profiles. The incidence of the neurotoxicity, the dermatological adverse effects and other miscellaneous ADRs was frequent, but not of high severity.

AB - This study compared the adverse drug reaction (ADR) profile in various anti-cancer regimens in 55 patients who attended a tertiary care centre. The adverse drug reactions which are caused by anticancer agents are common and they may be enhanced when the drugs are used in combinations. The cases which conformed to the inclusion criteriae were selected and the details were noted in a proforma, which were then statistically analyzed. The results which were obtained, showed that the ADRs were common, but that they occurred in a similar frequency as in other study groups and that the severity grade was low. The counter measures to tackle the adverse reactions were also effective, leading to a hundred percent survival through the six cycles and the two year survival, which in itself spoke volumes about the ADRs. These findings were in tune with the findings of various researchers in the field of anti cancer toxicity profiles. The incidence of the neurotoxicity, the dermatological adverse effects and other miscellaneous ADRs was frequent, but not of high severity.

UR - http://www.scopus.com/inward/record.url?scp=84861703403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861703403&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 1209

EP - 1213

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 2249-782X

IS - 6

ER -