A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

Benedicta D'Souza, Vivian D'Souza, S. Sowmya, G. Seema, C. N. Hemalatha, M. Anu, G. Sajana

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalIndian Journal of Clinical Biochemistry
Volume23
Issue number3
DOIs
Publication statusPublished - 01-12-2008
Externally publishedYes

Fingerprint

Oxidative stress
Medical problems
Oxidative Stress
Antioxidants
Stroke
Malondialdehyde
Ceruloplasmin
Uric Acid
Lipids
Lipid Peroxidation
Glutathione
Association reactions

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

D'Souza, Benedicta ; D'Souza, Vivian ; Sowmya, S. ; Seema, G. ; Hemalatha, C. N. ; Anu, M. ; Sajana, G. / A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes. In: Indian Journal of Clinical Biochemistry. 2008 ; Vol. 23, No. 3. pp. 218-222.
@article{9ec2adf4492c490db29ea328e9e5951a,
title = "A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes",
abstract = "The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.",
author = "Benedicta D'Souza and Vivian D'Souza and S. Sowmya and G. Seema and Hemalatha, {C. N.} and M. Anu and G. Sajana",
year = "2008",
month = "12",
day = "1",
doi = "10.1007/s12291-008-0049-8",
language = "English",
volume = "23",
pages = "218--222",
journal = "Indian Journal of Clinical Biochemistry",
issn = "0970-1915",
publisher = "Springer India",
number = "3",

}

A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes. / D'Souza, Benedicta; D'Souza, Vivian; Sowmya, S.; Seema, G.; Hemalatha, C. N.; Anu, M.; Sajana, G.

In: Indian Journal of Clinical Biochemistry, Vol. 23, No. 3, 01.12.2008, p. 218-222.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

AU - D'Souza, Benedicta

AU - D'Souza, Vivian

AU - Sowmya, S.

AU - Seema, G.

AU - Hemalatha, C. N.

AU - Anu, M.

AU - Sajana, G.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.

AB - The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs) with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes.

UR - http://www.scopus.com/inward/record.url?scp=56749169361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749169361&partnerID=8YFLogxK

U2 - 10.1007/s12291-008-0049-8

DO - 10.1007/s12291-008-0049-8

M3 - Article

VL - 23

SP - 218

EP - 222

JO - Indian Journal of Clinical Biochemistry

JF - Indian Journal of Clinical Biochemistry

SN - 0970-1915

IS - 3

ER -