TY - JOUR
T1 - A comprehensive review on the carcinogenic potential of bisphenol A
T2 - clues and evidence
AU - Khan, Nadeem Ghani
AU - Correia, Jacinta
AU - Adiga, Divya
AU - Rai, Padmalatha Satwadi
AU - Dsouza, Herman Sunil
AU - Chakrabarty, Sanjiban
AU - Kabekkodu, Shama Prasada
N1 - Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.
AB - Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.
UR - http://www.scopus.com/inward/record.url?scp=85102208963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102208963&partnerID=8YFLogxK
U2 - 10.1007/s11356-021-13071-w
DO - 10.1007/s11356-021-13071-w
M3 - Review article
AN - SCOPUS:85102208963
SN - 0944-1344
VL - 28
SP - 19643
EP - 19663
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 16
ER -
