A correlative study of glycosylated hemoglobin in normal and type 2 diabeteic patients

K. Narasimha Rai, P. S. Jeganathan

Research output: Contribution to journalArticle

Abstract

Obesity is a positive risk factor in the development of type 2 diabetes mellitus. For the last few years estimation of glycosylated hemoglobin & fructosamine has been increasingly used to achieve better monitoring of long term glycemic control in diabetics. The present study was undertaken to correlate glycosylated hemoglobin in normal and type 2 diabetes mellitus patients. The study group was divided into Control (non diabetic subjects, N=57), Group 1 (Diabetic only patients, N=58), and Group 2 (Diabetic with hypertension patients, N=58). Glycosylated hemoglobin was measured by auto analyzer method. Any value >7% were considered as increased HbA1c. HbA1c was measured after one month of recording FBS & PPBS levels. The mean value of FBS in Controls, Group1 and Group2 were 87.82 ± 1.21, 125.18 ± 4.82 and 127.25 ± 4.30 respectively. The mean value of PPBS in Controls, Group1 and Group2 were 126.10 ± 5.46, 186.03 ± 7.36 and 186.76 ± 6.55 respectively. The mean value of HbA1c in Controls, Group1 and Group2 were 7.08 ± 0.22, 8.01 ± 0.16 and 8.34 ± 0.15 respectively. When the inter comparison of Controls, Group1 and Group 2 for FBS, PPBS and HbA1c shows a significant increase in the level of all the three parameters (Tukey's test, P<0.001) in Group1 and Group2. The present data indicate that significant increase in FBS, PPBS and HbA1c levels in diabetics and diabetes with hypertension patients, the increase in HbA1c levels could be due to an increase in non enzymatic glycation of hemoglobin.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume1
Issue number3
Publication statusPublished - 01-07-2010
Externally publishedYes

Fingerprint

Glycosylated Hemoglobin A
Medical problems
Type 2 Diabetes Mellitus
Fructosamine
Hypertension
Hemoglobins
Obesity
Control Groups
Monitoring

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "A correlative study of glycosylated hemoglobin in normal and type 2 diabeteic patients",
abstract = "Obesity is a positive risk factor in the development of type 2 diabetes mellitus. For the last few years estimation of glycosylated hemoglobin & fructosamine has been increasingly used to achieve better monitoring of long term glycemic control in diabetics. The present study was undertaken to correlate glycosylated hemoglobin in normal and type 2 diabetes mellitus patients. The study group was divided into Control (non diabetic subjects, N=57), Group 1 (Diabetic only patients, N=58), and Group 2 (Diabetic with hypertension patients, N=58). Glycosylated hemoglobin was measured by auto analyzer method. Any value >7{\%} were considered as increased HbA1c. HbA1c was measured after one month of recording FBS & PPBS levels. The mean value of FBS in Controls, Group1 and Group2 were 87.82 ± 1.21, 125.18 ± 4.82 and 127.25 ± 4.30 respectively. The mean value of PPBS in Controls, Group1 and Group2 were 126.10 ± 5.46, 186.03 ± 7.36 and 186.76 ± 6.55 respectively. The mean value of HbA1c in Controls, Group1 and Group2 were 7.08 ± 0.22, 8.01 ± 0.16 and 8.34 ± 0.15 respectively. When the inter comparison of Controls, Group1 and Group 2 for FBS, PPBS and HbA1c shows a significant increase in the level of all the three parameters (Tukey's test, P<0.001) in Group1 and Group2. The present data indicate that significant increase in FBS, PPBS and HbA1c levels in diabetics and diabetes with hypertension patients, the increase in HbA1c levels could be due to an increase in non enzymatic glycation of hemoglobin.",
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A correlative study of glycosylated hemoglobin in normal and type 2 diabeteic patients. / Narasimha Rai, K.; Jeganathan, P. S.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 1, No. 3, 01.07.2010, p. 626-630.

Research output: Contribution to journalArticle

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