A correlative study of status of serum cholesterol, triglyceride and HDL-cholesterol in type 2 diabetes mellitus patients with and without hypertension

K. Narasimha Rai, P. S. Jeganathan

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Abstract

Individuals with Diabetes mellitus may have several forms of dyslipidemia. In obese patients with type II diabetes, a distinct "diabetic dyslipidemia" is characteristic of the insulin resistance syndrome. The present study was undertaken to correlate the serum cholesterol, triglyceride and HDL-Cholesterol levels in healthy participants and type 2 Diabetes mellitus patients. The present work was carried out at KMC hospital, Attavar, Mangalore, after a written consent from all the participants. The study includes 160 subjects and was divided into Group 1 with 57 non Diabetic subjects, Group 2 with 58 Diabetic patients without hypertension and Group 3 containing 45 Diabetes with hypertension patients respectively. About 5 ml of blood sample was collected and used for the estimation of serum cholesterol, triglyceride and HDL-Cholesterol levels using standard methods. Statistical analysis was done using one-way ANOVA and p<0.05 was considered as significant. From our study, we found that there was a significant increase (P<0.001) in serum cholesterol and triglyceride in Diabetic patients with or without hypertension, but HDL-cholesterol was declined significantly (P< 0.001) when compared to normal individuals. In type 2 Diabetes mellitus patients, an increase in serum cholesterol, triglycerides and decline in HDL-Cholesterols is due to an increased lipolysis which causes the liver to increase glucose, serum cholesterol and triglycerides. The decline in HDL-Cholesterols might be due to its reciprocal relation with triglycerides. In Diabetic patients, the serum-cholesterol and triglyceride level increases, where as HDL-cholesterol level declines.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume1
Issue number3
Publication statusPublished - 01-07-2010
Externally publishedYes

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Medical problems
Type 2 Diabetes Mellitus
HDL Cholesterol
Triglycerides
Cholesterol
Hypertension
Serum
Dyslipidemias
Lipolysis
Analysis of variance (ANOVA)
Liver
Insulin Resistance
Statistical methods
Diabetes Mellitus
Analysis of Variance
Healthy Volunteers
Blood
Insulin
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Individuals with Diabetes mellitus may have several forms of dyslipidemia. In obese patients with type II diabetes, a distinct {"}diabetic dyslipidemia{"} is characteristic of the insulin resistance syndrome. The present study was undertaken to correlate the serum cholesterol, triglyceride and HDL-Cholesterol levels in healthy participants and type 2 Diabetes mellitus patients. The present work was carried out at KMC hospital, Attavar, Mangalore, after a written consent from all the participants. The study includes 160 subjects and was divided into Group 1 with 57 non Diabetic subjects, Group 2 with 58 Diabetic patients without hypertension and Group 3 containing 45 Diabetes with hypertension patients respectively. About 5 ml of blood sample was collected and used for the estimation of serum cholesterol, triglyceride and HDL-Cholesterol levels using standard methods. Statistical analysis was done using one-way ANOVA and p<0.05 was considered as significant. From our study, we found that there was a significant increase (P<0.001) in serum cholesterol and triglyceride in Diabetic patients with or without hypertension, but HDL-cholesterol was declined significantly (P< 0.001) when compared to normal individuals. In type 2 Diabetes mellitus patients, an increase in serum cholesterol, triglycerides and decline in HDL-Cholesterols is due to an increased lipolysis which causes the liver to increase glucose, serum cholesterol and triglycerides. The decline in HDL-Cholesterols might be due to its reciprocal relation with triglycerides. In Diabetic patients, the serum-cholesterol and triglyceride level increases, where as HDL-cholesterol level declines.",
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