A cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients

K. Kosaraju, S. Shenoy, U. Suchithra

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Our study was aimed to analyze clinical manifestations, autoantibodies and other serological abnormalities in South Indian patients with systemic lupus erythematosus. Clinical history and findings on systemic examination were noted. Antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) were detected by immunofluorescence and ANA profile by Immunoblotting. Arthritis was most common followed by fever and skin rash. Clinical manifestations vary according to geographical location of the patient. ANA was positive in 64.28% and anti-dsDNA in 89.36% of patients. All patients with lupus nephritis were positive for dsDNA. Detection of antibodies to dsDNA, RNP and anti-Smith (Sm) are of diagnostic and prognostic importance.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalIndian Journal of Medical Microbiology
Volume28
Issue number3
DOIs
Publication statusPublished - 01-07-2010

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Systemic Lupus Erythematosus
Autoantibodies
Antinuclear Antibodies
DNA
Lupus Nephritis
Antibodies
Exanthema
Immunoblotting
Arthritis
Fluorescent Antibody Technique
Fever

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

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