A difficult case in clinical practice

combined polycythaemia vera and protein s deficiency in a patient with both thrombotic and bleeding complications

Sushanth Wattal, Ashwal Adamane Jayaram, Padmakumar Ramachandran, Abdul U.K. Razak, Suheil Dhanse

Research output: Contribution to journalArticle

Abstract

Polycythemia Vera (PV) is a chronic myeloproliferative disorder which is characterised by a high risk of developing arterial as well as venous thromboembolic complications like deep vein thrombosis, stroke, cortical vein thrombosis and rarely acute Myocardial Infarction (MI). PV has a risk rate of major thrombosis as high as 50%. Bleeding, thrombotic, and vascular complications are the major causes of morbidity and mortality, occurring in 40 to 60% of these patients. MI with heart failure is the most common cause of death in these patients. Congenital Protein S deficiency is an autosomal dominant disease. Venous thrombosis develops in 60-80% of patients who are heterozygous for Protein S deficiency. Hereditary Protein S deficiency is a well known risk factor not only for venous thrombosis but also for arterial thrombosis including MI and stroke. However, association of Protein S deficiency with arterial thrombosis is less appreciated. Very rarely, we find all the varied thrombotic complications in one patient. We hereby present a case who had varied thrombotic presentations due to underlying polycythemia with Protein S deficiency.

Original languageEnglish
Pages (from-to)OD11-OD14
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number4
DOIs
Publication statusPublished - 01-04-2018

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Protein S Deficiency
Protein Deficiency
Polycythemia Vera
Protein S
Hemorrhage
Thrombosis
Venous Thrombosis
Myocardial Infarction
Proteins
Stroke
Myeloproliferative Disorders
Polycythemia
Blood Vessels
Cause of Death
Veins
Heart Failure
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Polycythemia Vera (PV) is a chronic myeloproliferative disorder which is characterised by a high risk of developing arterial as well as venous thromboembolic complications like deep vein thrombosis, stroke, cortical vein thrombosis and rarely acute Myocardial Infarction (MI). PV has a risk rate of major thrombosis as high as 50{\%}. Bleeding, thrombotic, and vascular complications are the major causes of morbidity and mortality, occurring in 40 to 60{\%} of these patients. MI with heart failure is the most common cause of death in these patients. Congenital Protein S deficiency is an autosomal dominant disease. Venous thrombosis develops in 60-80{\%} of patients who are heterozygous for Protein S deficiency. Hereditary Protein S deficiency is a well known risk factor not only for venous thrombosis but also for arterial thrombosis including MI and stroke. However, association of Protein S deficiency with arterial thrombosis is less appreciated. Very rarely, we find all the varied thrombotic complications in one patient. We hereby present a case who had varied thrombotic presentations due to underlying polycythemia with Protein S deficiency.",
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A difficult case in clinical practice : combined polycythaemia vera and protein s deficiency in a patient with both thrombotic and bleeding complications. / Wattal, Sushanth; Jayaram, Ashwal Adamane; Ramachandran, Padmakumar; Razak, Abdul U.K.; Dhanse, Suheil.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 4, 01.04.2018, p. OD11-OD14.

Research output: Contribution to journalArticle

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