A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst

Namratha Bhandari, Santosh L. Gaonkar

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[MediaObject not available: see fulltext.]The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.

Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalChemistry of Heterocyclic Compounds
Issue number4
Publication statusPublished - 01-04-2015


All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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