A guide and guard

The many faces of T-cadherin

Maria Philippova, Manjunath B. Joshi, Emmanouil Kyriakakis, Dennis Pfaff, Paul Erne, Therese J. Resink

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member, lacking transmembrane and cytosolic domains and possessing a glycosylphosphatidylinositol moiety that anchors T-cadherin to the plasma membrane. This article reviews current knowledge on the biomolecular characteristics of T-cadherin, its expression and function in different tissues in health and disease and its mechanisms of signal transduction. The structural characteristics of T-cadherin protein predict that it is unlikely to function as a "true" adhesion molecule in vivo. Studies from different fields suggest that it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cellular expression levels of T-cadherin in various tissues frequently correlate (be it negatively or positively) with the proliferative potential of the cells. Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth. Gathering evidence suggests that the "functional predestination" of T-cadherin is in control of tissue architecture through "guiding" navigation of moving structures, segregating functional tissue compartments and "guarding" integrity of functionally connected tissue layers.

Original languageEnglish
Pages (from-to)1035-1044
Number of pages10
JournalCellular Signalling
Volume21
Issue number7
DOIs
Publication statusPublished - 07-2009

Fingerprint

H-cadherin
Cell Movement
Glycosylphosphatidylinositols
Cadherins
Signal Transduction
Proteins
Cell Proliferation
Cell Membrane
Calcium
Phenotype
Health
Growth

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Philippova, M., Joshi, M. B., Kyriakakis, E., Pfaff, D., Erne, P., & Resink, T. J. (2009). A guide and guard: The many faces of T-cadherin. Cellular Signalling, 21(7), 1035-1044. https://doi.org/10.1016/j.cellsig.2009.01.035
Philippova, Maria ; Joshi, Manjunath B. ; Kyriakakis, Emmanouil ; Pfaff, Dennis ; Erne, Paul ; Resink, Therese J. / A guide and guard : The many faces of T-cadherin. In: Cellular Signalling. 2009 ; Vol. 21, No. 7. pp. 1035-1044.
@article{6313f34fd49d491c88931e04bb4beb28,
title = "A guide and guard: The many faces of T-cadherin",
abstract = "Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member, lacking transmembrane and cytosolic domains and possessing a glycosylphosphatidylinositol moiety that anchors T-cadherin to the plasma membrane. This article reviews current knowledge on the biomolecular characteristics of T-cadherin, its expression and function in different tissues in health and disease and its mechanisms of signal transduction. The structural characteristics of T-cadherin protein predict that it is unlikely to function as a {"}true{"} adhesion molecule in vivo. Studies from different fields suggest that it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cellular expression levels of T-cadherin in various tissues frequently correlate (be it negatively or positively) with the proliferative potential of the cells. Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth. Gathering evidence suggests that the {"}functional predestination{"} of T-cadherin is in control of tissue architecture through {"}guiding{"} navigation of moving structures, segregating functional tissue compartments and {"}guarding{"} integrity of functionally connected tissue layers.",
author = "Maria Philippova and Joshi, {Manjunath B.} and Emmanouil Kyriakakis and Dennis Pfaff and Paul Erne and Resink, {Therese J.}",
year = "2009",
month = "7",
doi = "10.1016/j.cellsig.2009.01.035",
language = "English",
volume = "21",
pages = "1035--1044",
journal = "Cellular Signalling",
issn = "0898-6568",
publisher = "Elsevier Inc.",
number = "7",

}

Philippova, M, Joshi, MB, Kyriakakis, E, Pfaff, D, Erne, P & Resink, TJ 2009, 'A guide and guard: The many faces of T-cadherin', Cellular Signalling, vol. 21, no. 7, pp. 1035-1044. https://doi.org/10.1016/j.cellsig.2009.01.035

A guide and guard : The many faces of T-cadherin. / Philippova, Maria; Joshi, Manjunath B.; Kyriakakis, Emmanouil; Pfaff, Dennis; Erne, Paul; Resink, Therese J.

In: Cellular Signalling, Vol. 21, No. 7, 07.2009, p. 1035-1044.

Research output: Contribution to journalReview article

TY - JOUR

T1 - A guide and guard

T2 - The many faces of T-cadherin

AU - Philippova, Maria

AU - Joshi, Manjunath B.

AU - Kyriakakis, Emmanouil

AU - Pfaff, Dennis

AU - Erne, Paul

AU - Resink, Therese J.

PY - 2009/7

Y1 - 2009/7

N2 - Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member, lacking transmembrane and cytosolic domains and possessing a glycosylphosphatidylinositol moiety that anchors T-cadherin to the plasma membrane. This article reviews current knowledge on the biomolecular characteristics of T-cadherin, its expression and function in different tissues in health and disease and its mechanisms of signal transduction. The structural characteristics of T-cadherin protein predict that it is unlikely to function as a "true" adhesion molecule in vivo. Studies from different fields suggest that it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cellular expression levels of T-cadherin in various tissues frequently correlate (be it negatively or positively) with the proliferative potential of the cells. Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth. Gathering evidence suggests that the "functional predestination" of T-cadherin is in control of tissue architecture through "guiding" navigation of moving structures, segregating functional tissue compartments and "guarding" integrity of functionally connected tissue layers.

AB - Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member, lacking transmembrane and cytosolic domains and possessing a glycosylphosphatidylinositol moiety that anchors T-cadherin to the plasma membrane. This article reviews current knowledge on the biomolecular characteristics of T-cadherin, its expression and function in different tissues in health and disease and its mechanisms of signal transduction. The structural characteristics of T-cadherin protein predict that it is unlikely to function as a "true" adhesion molecule in vivo. Studies from different fields suggest that it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cellular expression levels of T-cadherin in various tissues frequently correlate (be it negatively or positively) with the proliferative potential of the cells. Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth. Gathering evidence suggests that the "functional predestination" of T-cadherin is in control of tissue architecture through "guiding" navigation of moving structures, segregating functional tissue compartments and "guarding" integrity of functionally connected tissue layers.

UR - http://www.scopus.com/inward/record.url?scp=67349278461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349278461&partnerID=8YFLogxK

U2 - 10.1016/j.cellsig.2009.01.035

DO - 10.1016/j.cellsig.2009.01.035

M3 - Review article

VL - 21

SP - 1035

EP - 1044

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 7

ER -

Philippova M, Joshi MB, Kyriakakis E, Pfaff D, Erne P, Resink TJ. A guide and guard: The many faces of T-cadherin. Cellular Signalling. 2009 Jul;21(7):1035-1044. https://doi.org/10.1016/j.cellsig.2009.01.035