A histomorphological pattern analysis of pulmonary tuberculosis in lung autopsy and surgically resected specimens

Mamta Gupta, Flora D. Lobo, Deepa Sowkur Anandarama Adiga, Abhishek Gupta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of diagnosis was 41 years with male predominance (92.5%). Tuberculosis was suspected in only 12.1% of cases before death. Seven cases were operated upon due to associated complications or suspicion of malignancy. Tubercular consolidation was the most frequent pattern followed by miliary tuberculosis. The presence of necrotizing granulomas was seen in 33 cases (82.5%). Acid fast bacilli were seen in 57.5% cases on Ziehl-Neelsen stain. Conclusion. Histopathology remains one of the most important methods for diagnosing tuberculosis, especially in TB prevalent areas. It should be considered in the differential diagnosis of all respiratory diseases because of its varied clinical presentations and manifestations.

Original languageEnglish
Article number8132741
JournalPathology Research International
Volume2016
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Pulmonary Tuberculosis
Autopsy
Tuberculosis
Lung
Bacillus
Miliary Tuberculosis
Granuloma
Mycobacterium tuberculosis
Differential Diagnosis
Coloring Agents
Morbidity
Acids
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{0a5236e1dde441e591f00aacc16245a4,
title = "A histomorphological pattern analysis of pulmonary tuberculosis in lung autopsy and surgically resected specimens",
abstract = "Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of diagnosis was 41 years with male predominance (92.5{\%}). Tuberculosis was suspected in only 12.1{\%} of cases before death. Seven cases were operated upon due to associated complications or suspicion of malignancy. Tubercular consolidation was the most frequent pattern followed by miliary tuberculosis. The presence of necrotizing granulomas was seen in 33 cases (82.5{\%}). Acid fast bacilli were seen in 57.5{\%} cases on Ziehl-Neelsen stain. Conclusion. Histopathology remains one of the most important methods for diagnosing tuberculosis, especially in TB prevalent areas. It should be considered in the differential diagnosis of all respiratory diseases because of its varied clinical presentations and manifestations.",
author = "Mamta Gupta and Lobo, {Flora D.} and Adiga, {Deepa Sowkur Anandarama} and Abhishek Gupta",
year = "2016",
month = "1",
day = "1",
doi = "10.1155/2016/8132741",
language = "English",
volume = "2016",
journal = "Pathology Research International",
issn = "2042-003X",
publisher = "Hindawi Publishing Corporation",

}

A histomorphological pattern analysis of pulmonary tuberculosis in lung autopsy and surgically resected specimens. / Gupta, Mamta; Lobo, Flora D.; Adiga, Deepa Sowkur Anandarama; Gupta, Abhishek.

In: Pathology Research International, Vol. 2016, 8132741, 01.01.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A histomorphological pattern analysis of pulmonary tuberculosis in lung autopsy and surgically resected specimens

AU - Gupta, Mamta

AU - Lobo, Flora D.

AU - Adiga, Deepa Sowkur Anandarama

AU - Gupta, Abhishek

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of diagnosis was 41 years with male predominance (92.5%). Tuberculosis was suspected in only 12.1% of cases before death. Seven cases were operated upon due to associated complications or suspicion of malignancy. Tubercular consolidation was the most frequent pattern followed by miliary tuberculosis. The presence of necrotizing granulomas was seen in 33 cases (82.5%). Acid fast bacilli were seen in 57.5% cases on Ziehl-Neelsen stain. Conclusion. Histopathology remains one of the most important methods for diagnosing tuberculosis, especially in TB prevalent areas. It should be considered in the differential diagnosis of all respiratory diseases because of its varied clinical presentations and manifestations.

AB - Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of diagnosis was 41 years with male predominance (92.5%). Tuberculosis was suspected in only 12.1% of cases before death. Seven cases were operated upon due to associated complications or suspicion of malignancy. Tubercular consolidation was the most frequent pattern followed by miliary tuberculosis. The presence of necrotizing granulomas was seen in 33 cases (82.5%). Acid fast bacilli were seen in 57.5% cases on Ziehl-Neelsen stain. Conclusion. Histopathology remains one of the most important methods for diagnosing tuberculosis, especially in TB prevalent areas. It should be considered in the differential diagnosis of all respiratory diseases because of its varied clinical presentations and manifestations.

UR - http://www.scopus.com/inward/record.url?scp=84964879494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964879494&partnerID=8YFLogxK

U2 - 10.1155/2016/8132741

DO - 10.1155/2016/8132741

M3 - Article

VL - 2016

JO - Pathology Research International

JF - Pathology Research International

SN - 2042-003X

M1 - 8132741

ER -