A knowledgebase resource for interleukin-17 family mediated signaling

Jyoti Sharma, Lavanya Balakrishnan, Keshava K. Datta, Nandini A. Sahasrabuddhe, Aafaque Ahmad Khan, Apeksha Sahu, Anish Singhal, Derese Getnet, Rajesh Raju, Aditi Chatterjee, Harsha Gowda, T. S. Keshava Prasad, Subramanian Shankar, Akhilesh Pandey

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16 Citations (Scopus)

Abstract

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalJournal of Cell Communication and Signaling
Volume9
Issue number3
DOIs
Publication statusPublished - 29-09-2015
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Sharma, J., Balakrishnan, L., Datta, K. K., Sahasrabuddhe, N. A., Khan, A. A., Sahu, A., Singhal, A., Getnet, D., Raju, R., Chatterjee, A., Gowda, H., Keshava Prasad, T. S., Shankar, S., & Pandey, A. (2015). A knowledgebase resource for interleukin-17 family mediated signaling. Journal of Cell Communication and Signaling, 9(3), 291-296. https://doi.org/10.1007/s12079-015-0297-3