TY - JOUR
T1 - A mitochondrial DNA variant 10398G>A in breast cancer among South Indians
T2 - An original study with meta-analysis
AU - Francis, Amirtharaj
AU - Pooja, Singh
AU - Rajender, Singh
AU - Govindaraj, Periyasamy
AU - Tipirisetti, Nageswara Rao
AU - Surekha, Daminani
AU - Rao, Digumarthi Raghunatha
AU - Rao, Lakshmi
AU - Ramachandra, Lingadakai
AU - Vishnupriya, Satti
AU - Ramalingam, K.
AU - Satyamoorthy, Kapaettu
AU - Thangaraj, Kumarasamy
PY - 2013/11
Y1 - 2013/11
N2 - The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.
AB - The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.
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U2 - 10.1016/j.mito.2013.08.004
DO - 10.1016/j.mito.2013.08.004
M3 - Article
C2 - 23993954
AN - SCOPUS:84884188763
SN - 1567-7249
VL - 13
SP - 559
EP - 565
JO - Mitochondrion
JF - Mitochondrion
IS - 6
ER -
