The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.
All Science Journal Classification (ASJC) codes
- Cell Biology
- Molecular Biology
- Molecular Medicine