A mitochondrial DNA variant 10398G>A in breast cancer among South Indians

An original study with meta-analysis

Amirtharaj Francis, Singh Pooja, Singh Rajender, Periyasamy Govindaraj, Nageswara Rao Tipirisetti, Daminani Surekha, Digumarthi Raghunatha Rao, Lakshmi Rao, Lingadakai Ramachandra, Satti Vishnupriya, K. Ramalingam, Kapaettu Satyamoorthy, Kumarasamy Thangaraj

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalMitochondrion
Volume13
Issue number6
DOIs
Publication statusPublished - 11-2013

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Mitochondrial DNA
Meta-Analysis
Breast Neoplasms
Neurodegenerative Diseases
India
Odds Ratio
Research
Population
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine

Cite this

Francis, A., Pooja, S., Rajender, S., Govindaraj, P., Tipirisetti, N. R., Surekha, D., ... Thangaraj, K. (2013). A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: An original study with meta-analysis. Mitochondrion, 13(6), 559-565. https://doi.org/10.1016/j.mito.2013.08.004
Francis, Amirtharaj ; Pooja, Singh ; Rajender, Singh ; Govindaraj, Periyasamy ; Tipirisetti, Nageswara Rao ; Surekha, Daminani ; Rao, Digumarthi Raghunatha ; Rao, Lakshmi ; Ramachandra, Lingadakai ; Vishnupriya, Satti ; Ramalingam, K. ; Satyamoorthy, Kapaettu ; Thangaraj, Kumarasamy. / A mitochondrial DNA variant 10398G>A in breast cancer among South Indians : An original study with meta-analysis. In: Mitochondrion. 2013 ; Vol. 13, No. 6. pp. 559-565.
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title = "A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: An original study with meta-analysis",
abstract = "The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.",
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Francis, A, Pooja, S, Rajender, S, Govindaraj, P, Tipirisetti, NR, Surekha, D, Rao, DR, Rao, L, Ramachandra, L, Vishnupriya, S, Ramalingam, K, Satyamoorthy, K & Thangaraj, K 2013, 'A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: An original study with meta-analysis', Mitochondrion, vol. 13, no. 6, pp. 559-565. https://doi.org/10.1016/j.mito.2013.08.004

A mitochondrial DNA variant 10398G>A in breast cancer among South Indians : An original study with meta-analysis. / Francis, Amirtharaj; Pooja, Singh; Rajender, Singh; Govindaraj, Periyasamy; Tipirisetti, Nageswara Rao; Surekha, Daminani; Rao, Digumarthi Raghunatha; Rao, Lakshmi; Ramachandra, Lingadakai; Vishnupriya, Satti; Ramalingam, K.; Satyamoorthy, Kapaettu; Thangaraj, Kumarasamy.

In: Mitochondrion, Vol. 13, No. 6, 11.2013, p. 559-565.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A mitochondrial DNA variant 10398G>A in breast cancer among South Indians

T2 - An original study with meta-analysis

AU - Francis, Amirtharaj

AU - Pooja, Singh

AU - Rajender, Singh

AU - Govindaraj, Periyasamy

AU - Tipirisetti, Nageswara Rao

AU - Surekha, Daminani

AU - Rao, Digumarthi Raghunatha

AU - Rao, Lakshmi

AU - Ramachandra, Lingadakai

AU - Vishnupriya, Satti

AU - Ramalingam, K.

AU - Satyamoorthy, Kapaettu

AU - Thangaraj, Kumarasamy

PY - 2013/11

Y1 - 2013/11

N2 - The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.

AB - The m.10398G. >. A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G. >. A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G. >. A polymorphism and breast cancer [OR. =. 0.916 (0.743-1.128); P. =. 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G. >. A substitution with breast cancer [OR. =. 1.016 (0.85-1.22); P. =. 0.86]. In conclusion, there is no evidence of association between m.10398G. >. A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.

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