A novel gene THSD7A is associated with obesity

S. Nizamuddin, P. Govindaraj, S. Saxena, M. Kashyap, A. Mishra, S. Singh, H. Rotti, R. Raval, J. Nayak, B. K. Bhat, B. V. Prasanna, V. R. Dhumal, S. Bhale, K. S. Joshi, A. P. Dedge, R. Bharadwaj, G. G. Gangadharan, S. Nair, P. M. Gopinath, B. PatwardhanP. Kondaiah, K. Satyamoorthy, M. S. Valiathan, K. Thangaraj

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Abstract

Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P≤3.75 × 10 -5), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10 -5, 8.922 × 10 -6 and 2.504 × 10 -9 in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.

Original languageEnglish
Pages (from-to)1662-1665
Number of pages4
JournalInternational Journal of Obesity
Volume39
Issue number11
DOIs
Publication statusPublished - 01-11-2015

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Nizamuddin, S., Govindaraj, P., Saxena, S., Kashyap, M., Mishra, A., Singh, S., ... Thangaraj, K. (2015). A novel gene THSD7A is associated with obesity. International Journal of Obesity, 39(11), 1662-1665. https://doi.org/10.1038/ijo.2015.144