A novel prediction model for risk stratification in patients with a type 1 Brugada ECG pattern

Muthiah Subramanian, Mukund A. Prabhu, Maneesh Rai, M. S. Harikrishnan, Saritha Sekhar, Praveen G. Pai, Kumaraswamy U. Natarajan

Research output: Contribution to journalArticle

Abstract

Background: Risk stratification in Brugada syndrome remains a controversial and unresolved clinical problem, especially in asymptomatic patients with a type 1 ECG pattern. The purpose of this study is to derive and validate a prediction model based on clinical and ECG parameters to effectively identify patients with a type 1 ECG pattern who are at high risk of major arrhythmic events (MAE)during follow-up. Methods: This study analysed data from 103 consecutive patients with Brugada Type 1 ECG pattern and no history of previous cardiac arrest. The prediction model was derived using logistic regression with MAE as the primary outcome, and patient demographic and electrocardiographic parameters as potential predictor variables. The model was externally validated in an independent cohort of 42 patients. Results: The final model (Brugada Risk Stratification [BRS]score)consisted of 4 independent predictors (1 point each)of MAE during follow-up (median 85.3 months): spontaneous type 1 pattern, QRS fragments in inferior leads≥3,S wave upslope duration ratio ≥ 0.8, and T peak – T end ≥ 100 ms. The BRS score (AUC = 0.95,95% CI 0.0.92–0.98)stratifies patients with a type 1 ECG pattern into low (BRS score ≤ 2)and high (BRS score ≥ 3)risk classes, with a class specific risk of MAE of 0–1.1% and 92.3–100% across the derivation and validation cohorts, respectively. Conclusions: The BRS score is a simple bed-side tool with high predictive accuracy, for risk stratification of patients with a Brugada Type 1 ECG pattern. Prospective validation of the prediction model is necessary before this score can be implemented in clinical practice.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalJournal of Electrocardiology
Volume55
DOIs
Publication statusPublished - 01-07-2019

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Brugada Syndrome
Electrocardiography
Heart Arrest
Area Under Curve
Logistic Models
Demography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Subramanian, Muthiah ; Prabhu, Mukund A. ; Rai, Maneesh ; Harikrishnan, M. S. ; Sekhar, Saritha ; Pai, Praveen G. ; Natarajan, Kumaraswamy U. / A novel prediction model for risk stratification in patients with a type 1 Brugada ECG pattern. In: Journal of Electrocardiology. 2019 ; Vol. 55. pp. 65-71.
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A novel prediction model for risk stratification in patients with a type 1 Brugada ECG pattern. / Subramanian, Muthiah; Prabhu, Mukund A.; Rai, Maneesh; Harikrishnan, M. S.; Sekhar, Saritha; Pai, Praveen G.; Natarajan, Kumaraswamy U.

In: Journal of Electrocardiology, Vol. 55, 01.07.2019, p. 65-71.

Research output: Contribution to journalArticle

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AU - Natarajan, Kumaraswamy U.

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