A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai, Arun M. Isloor, Prakash Shetty, Nishitha Isloor, Mahesh Padaki, Hoong Kun Fun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

Original languageEnglish
Pages (from-to)1090-1097
Number of pages8
JournalMedicinal Chemistry Research
Volume21
Issue number7
DOIs
Publication statusPublished - 01-07-2012

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this