A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai, Arun M. Isloor, Prakash Shetty, Nishitha Isloor, Mahesh Padaki, Hoong Kun Fun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

Original languageEnglish
Pages (from-to)1090-1097
Number of pages8
JournalMedicinal Chemistry Research
Volume21
Issue number7
DOIs
Publication statusPublished - 01-07-2012

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Amines
Halogen compounds
Trifluoroacetic Acid
Halogens
X ray analysis
Aldehydes
X-Rays
Single crystals
Catalysts

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Rai, U. Sankappa ; Isloor, Arun M. ; Shetty, Prakash ; Isloor, Nishitha ; Padaki, Mahesh ; Fun, Hoong Kun. / A novel series of homoallylic amines as potential antimicrobials. In: Medicinal Chemistry Research. 2012 ; Vol. 21, No. 7. pp. 1090-1097.
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A novel series of homoallylic amines as potential antimicrobials. / Rai, U. Sankappa; Isloor, Arun M.; Shetty, Prakash; Isloor, Nishitha; Padaki, Mahesh; Fun, Hoong Kun.

In: Medicinal Chemistry Research, Vol. 21, No. 7, 01.07.2012, p. 1090-1097.

Research output: Contribution to journalArticle

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