Metal oxides form part of inorganic medicines called Bhasmas, which has been used in a non-allopathic medicine system practiced in India called Ayurveda. Bhasmas may be classified under the nano medicines of ancient India. The traditional preparation methods involve time consuming and complicated preparation procedures. This paper highlights a novel ultrasound assisted technique called sonochemical synthesis of transition metal oxides in a facile, faster, inherently safer and environmentally benign (green chemistry) way which could be considered to be used for the synthesis of metal oxides such as copper oxide which form part of the copper based Ayurvedic nano medicine called tamra bhasma, which is copper in its oxide form and used therapeutically as a source of copper. The synthesis procedure outlined here could be considered for the preparation of other types of Bhasmas also.