A pathway map of glutamate metabolism

Soujanya D. Yelamanchi, Savita Jayaram, Joji Kurian Thomas, Seetaramanjaneyulu Gundimeda, Aafaque Ahmad Khan, Anish Singhal, T. S. Keshava Prasad, Akhilesh Pandey, B. L. Somani, Harsha Gowda

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalJournal of Cell Communication and Signaling
Volume10
Issue number1
DOIs
Publication statusPublished - 01-03-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Yelamanchi, S. D., Jayaram, S., Thomas, J. K., Gundimeda, S., Khan, A. A., Singhal, A., Keshava Prasad, T. S., Pandey, A., Somani, B. L., & Gowda, H. (2016). A pathway map of glutamate metabolism. Journal of Cell Communication and Signaling, 10(1), 69-75. https://doi.org/10.1007/s12079-015-0315-5