A pilot study of the antioxidant effect of curcumin in tropical pancreatitis

S. Durgaprasad, C. Ganesh Pai, Vasanthkumar, Jose Filipe Alvres, Sanjeeva, Namitha

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Background & objectives: Oxidative stress occurs in association with painful exacerbations of chronic pancreatitis and antioxidant supplementation appears to benefit this condition. Curcumin, the active constituent of turmeric, is known to exhibit antioxidant activity. This pilot study was therefore undertaken to evaluate the effect of oral curcumin with piperine on the pain, and the markers of oxidative stress in patients with tropical pancreatitis (TP). Methods: Twenty consecutive patients with tropical pancreatitis were randomised to receive 500mg of curcumin with 5mg of piperine, or placebo for 6 wk, and the effects on the pattern of pain, and on red blood cell levels of malonyldialdehyde (MDA) and glutathione (GSH) were assessed. Results: There was a significant reduction in the erythrocyte MDA levels following curcumin therapy compared with placebo; with a significant increase in GSH levels. There was no corresponding improvement in pain. Interpretation & conclusion: Oral curcumin with piperine reversed lipid peroxidation in patients with tropical pancreatitis. Further studies with large sample are needed to define its effect on the pain and other manifestations of tropical pancreatitis.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalIndian Journal of Medical Research
Volume122
Issue number4
Publication statusPublished - 01-10-2005

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piperine
Curcumin
Pancreatitis
Antioxidants
Pain
Oxidative stress
Malondialdehyde
Oxidative Stress
Erythrocytes
Placebos
Curcuma
Chronic Pancreatitis
Lipid Peroxidation
Glutathione
Blood
Cells
Association reactions
Lipids

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Durgaprasad, S., Ganesh Pai, C., Vasanthkumar, Alvres, J. F., Sanjeeva, & Namitha (2005). A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian Journal of Medical Research, 122(4), 315-318.
Durgaprasad, S. ; Ganesh Pai, C. ; Vasanthkumar ; Alvres, Jose Filipe ; Sanjeeva ; Namitha. / A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. In: Indian Journal of Medical Research. 2005 ; Vol. 122, No. 4. pp. 315-318.
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Durgaprasad, S, Ganesh Pai, C, Vasanthkumar, Alvres, JF, Sanjeeva & Namitha 2005, 'A pilot study of the antioxidant effect of curcumin in tropical pancreatitis', Indian Journal of Medical Research, vol. 122, no. 4, pp. 315-318.

A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. / Durgaprasad, S.; Ganesh Pai, C.; Vasanthkumar; Alvres, Jose Filipe; Sanjeeva; Namitha.

In: Indian Journal of Medical Research, Vol. 122, No. 4, 01.10.2005, p. 315-318.

Research output: Contribution to journalArticle

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N2 - Background & objectives: Oxidative stress occurs in association with painful exacerbations of chronic pancreatitis and antioxidant supplementation appears to benefit this condition. Curcumin, the active constituent of turmeric, is known to exhibit antioxidant activity. This pilot study was therefore undertaken to evaluate the effect of oral curcumin with piperine on the pain, and the markers of oxidative stress in patients with tropical pancreatitis (TP). Methods: Twenty consecutive patients with tropical pancreatitis were randomised to receive 500mg of curcumin with 5mg of piperine, or placebo for 6 wk, and the effects on the pattern of pain, and on red blood cell levels of malonyldialdehyde (MDA) and glutathione (GSH) were assessed. Results: There was a significant reduction in the erythrocyte MDA levels following curcumin therapy compared with placebo; with a significant increase in GSH levels. There was no corresponding improvement in pain. Interpretation & conclusion: Oral curcumin with piperine reversed lipid peroxidation in patients with tropical pancreatitis. Further studies with large sample are needed to define its effect on the pain and other manifestations of tropical pancreatitis.

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Durgaprasad S, Ganesh Pai C, Vasanthkumar, Alvres JF, Sanjeeva, Namitha. A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian Journal of Medical Research. 2005 Oct 1;122(4):315-318.