A preliminary study of optical biosensor towards blood-glucose measurements

Research output: Contribution to journalArticle

Abstract

Surface plasmons are the collective electron wave on the nanoscale thin film of metals. Under suitable conditions, these surface waves can be excited to create surface plasmon resonance. The resonance condition is extremely sensitive to the refractive index of the medium, making it a suitable technique for sensing purposes. The objective of the present work was to study the dependence of SPR curve on various parameters theoretically and to study SPR curve for air, water and aqueous solution of glucose using an SPR experimental set up. To construct the set up, parameters were calculated using a simulation program (in MATLAB) based on the three layer solution of the Fresnel equation. Dependence of the excitation wavelength and the thickness of the metal film on the SPR signature were investigated. Also, the limit of detection was estimated for given parameters. Experimentally, the dielectric media, air, water and aqueous solution of glucose were measured using the home built experimental set up. The obtained data were corrected for the refraction inside the glass prism. In case of the solutions, the refractive index change up to 9.7x10-4 RIU was detected successfully.

Original languageEnglish
Pages (from-to)8700-8704
Number of pages5
JournalInternational Journal of Pharmacy and Technology
Volume7
Issue number2
Publication statusPublished - 01-07-2015

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Biosensing Techniques
Biosensors
Glucose
Blood Glucose
Blood
Refractometry
Refractive index
Metals
Air
Plasmons
Surface Plasmon Resonance
Water
Surface plasmon resonance
Prisms
Refraction
Surface waves
MATLAB
Glass
Limit of Detection
Electrons

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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A preliminary study of optical biosensor towards blood-glucose measurements. / Laxmi, N.; Sinha, Rajeev Kumar.

In: International Journal of Pharmacy and Technology, Vol. 7, No. 2, 01.07.2015, p. 8700-8704.

Research output: Contribution to journalArticle

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