A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

H. B. Sridevi, P. R. Shanthala, C. V. Raghuveer, Ananth K. Prabhu, Jallaluddin K.C. Akbar, G. S. Shivaprasad, Pooja K. Suresh, Sanjay Navani

Research output: Contribution to journalArticle

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Abstract

Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.

Original languageEnglish
Number of pages1
JournalJournal of Cancer Research and Therapeutics
Volume11
Issue number3
DOIs
Publication statusPublished - 01-01-2015

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Primary Cutaneous Anaplastic Large Cell Lymphoma
Young Adult
Lymphoma
Skin
Anaplastic Large-Cell Lymphoma
Neck
Tomography
Biopsy
Drug Therapy
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Sridevi, H. B. ; Shanthala, P. R. ; Raghuveer, C. V. ; Prabhu, Ananth K. ; Akbar, Jallaluddin K.C. ; Shivaprasad, G. S. ; Suresh, Pooja K. ; Navani, Sanjay. / A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult. In: Journal of Cancer Research and Therapeutics. 2015 ; Vol. 11, No. 3.
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abstract = "Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.",
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A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult. / Sridevi, H. B.; Shanthala, P. R.; Raghuveer, C. V.; Prabhu, Ananth K.; Akbar, Jallaluddin K.C.; Shivaprasad, G. S.; Suresh, Pooja K.; Navani, Sanjay.

In: Journal of Cancer Research and Therapeutics, Vol. 11, No. 3, 01.01.2015.

Research output: Contribution to journalArticle

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T1 - A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

AU - Sridevi, H. B.

AU - Shanthala, P. R.

AU - Raghuveer, C. V.

AU - Prabhu, Ananth K.

AU - Akbar, Jallaluddin K.C.

AU - Shivaprasad, G. S.

AU - Suresh, Pooja K.

AU - Navani, Sanjay

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AB - Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.

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