A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure

B. Sadananda Naik, M. Chakrapani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Brucine is the predominant alkaloid present in the bark of the tree Strychnos nux vomica and is a weaker alkaloid when compared to strychnine. However, its toxicological property is akin to strychnine. We report a rare case of brucine poisoning complicated by acute renal failure and rhabdomyolysis. A 24-year-old male presented with a history of consumption of a decoction made from the bark of the Strychnos nux vomica tree. Soon after, he developed widespread muscle spasms and convulsions, which were promptly treated. On the fifth day of admission, he developed features of rhabdomyolysis and acute renal failure. Investigations revealed elevated creatine phosphokinase levels and elevated blood urea and serum creatinine. The patient was managed with hemodialysis and recovered gradually. There are many reports of strychnine poisoning producing rhabdomyolysis and renal failure. In this case report, attention is drawn to the fact that brucine, although a weaker alkaloid, can also produce life threatening complications like rhabdomyolysis and acute renal failure.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalMalaysian Journal of Pathology
Volume31
Issue number1
Publication statusPublished - 06-2009

Fingerprint

Rhabdomyolysis
Acute Kidney Injury
Strychnine
Poisoning
Strychnos nux-vomica
Alkaloids
Plant Bark
Spasm
Creatine Kinase
Toxicology
Renal Insufficiency
Renal Dialysis
Urea
Creatinine
Seizures
brucine
Serum

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Medicine(all)
  • Cell Biology

Cite this

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A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. / Naik, B. Sadananda; Chakrapani, M.

In: Malaysian Journal of Pathology, Vol. 31, No. 1, 06.2009, p. 67-69.

Research output: Contribution to journalArticle

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AB - Brucine is the predominant alkaloid present in the bark of the tree Strychnos nux vomica and is a weaker alkaloid when compared to strychnine. However, its toxicological property is akin to strychnine. We report a rare case of brucine poisoning complicated by acute renal failure and rhabdomyolysis. A 24-year-old male presented with a history of consumption of a decoction made from the bark of the Strychnos nux vomica tree. Soon after, he developed widespread muscle spasms and convulsions, which were promptly treated. On the fifth day of admission, he developed features of rhabdomyolysis and acute renal failure. Investigations revealed elevated creatine phosphokinase levels and elevated blood urea and serum creatinine. The patient was managed with hemodialysis and recovered gradually. There are many reports of strychnine poisoning producing rhabdomyolysis and renal failure. In this case report, attention is drawn to the fact that brucine, although a weaker alkaloid, can also produce life threatening complications like rhabdomyolysis and acute renal failure.

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