A rare case of malignant fibrous histiocytoma of the gingiva

Rupali Agnihotri, K. Mahalinga Bhat, G. Subraya Bhat

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Malignant fibrous histiocytoma (MFH) is an aggressive, high-grade tumor with poor prognosis. It is the most common soft tissue sarcoma in adults, usually occurring retroperitoneally in extremities. MFH of the head and neck is rare. Cases with primary involvement of only the oral soft tissues have been reported; a few occurred in the gingiva. Its clinical features include a painless enlarging mass, which may or may not be ulcerated. Methods: A 20-year-old female patient presented with a non-healing necrotic ulceration of 4 months' duration on the maxillary anterior labial gingiva. Based on her history and agricultural background, a provisional diagnosis of chronic fungal and chronic bacterial infection was given. The patient was placed on a topical antifungal in combination with antibiotic therapy for 10 days. Because the lesion failed to respond to the initial therapy, an incisional biopsy was performed. The lesion was diagnosed as MFH based on clinical, histopathologic, and immunohistochemical findings. Results: The patient was referred to the Department of Oncology and Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, for further evaluation and treatment; the lesion was treated by resection of the premaxilla, and a splint was placed. She was followed up for 3 months with improvement in her condition. Conclusions: Because MFH is rare in the oral cavity, misdiagnosis may not be unusual based on the initial clinical examination. Any suspicious lesion that is unresponsive to treatment must be subjected to histopathologic evaluation to arrive at a final diagnosis.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalJournal of Periodontology
Volume79
Issue number5
DOIs
Publication statusPublished - 01-05-2008

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Malignant Fibrous Histiocytoma
Gingiva
Oral Surgery
Splints
Therapeutics
Lip
Diagnostic Errors
Bacterial Infections
Sarcoma
Mouth
Tooth
Neck
Extremities
History
Head
Anti-Bacterial Agents
Biopsy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Agnihotri, Rupali ; Mahalinga Bhat, K. ; Subraya Bhat, G. / A rare case of malignant fibrous histiocytoma of the gingiva. In: Journal of Periodontology. 2008 ; Vol. 79, No. 5. pp. 955-960.
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abstract = "Background: Malignant fibrous histiocytoma (MFH) is an aggressive, high-grade tumor with poor prognosis. It is the most common soft tissue sarcoma in adults, usually occurring retroperitoneally in extremities. MFH of the head and neck is rare. Cases with primary involvement of only the oral soft tissues have been reported; a few occurred in the gingiva. Its clinical features include a painless enlarging mass, which may or may not be ulcerated. Methods: A 20-year-old female patient presented with a non-healing necrotic ulceration of 4 months' duration on the maxillary anterior labial gingiva. Based on her history and agricultural background, a provisional diagnosis of chronic fungal and chronic bacterial infection was given. The patient was placed on a topical antifungal in combination with antibiotic therapy for 10 days. Because the lesion failed to respond to the initial therapy, an incisional biopsy was performed. The lesion was diagnosed as MFH based on clinical, histopathologic, and immunohistochemical findings. Results: The patient was referred to the Department of Oncology and Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, for further evaluation and treatment; the lesion was treated by resection of the premaxilla, and a splint was placed. She was followed up for 3 months with improvement in her condition. Conclusions: Because MFH is rare in the oral cavity, misdiagnosis may not be unusual based on the initial clinical examination. Any suspicious lesion that is unresponsive to treatment must be subjected to histopathologic evaluation to arrive at a final diagnosis.",
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A rare case of malignant fibrous histiocytoma of the gingiva. / Agnihotri, Rupali; Mahalinga Bhat, K.; Subraya Bhat, G.

In: Journal of Periodontology, Vol. 79, No. 5, 01.05.2008, p. 955-960.

Research output: Contribution to journalArticle

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