A rising threat – Risk factors and outcomes related to infections with Acinetobacter species

Prerna Khurana, Shrikala Baliga, M. Suchitra Shenoy, P. Prasanna Mithra

Research output: Contribution to journalArticle

Abstract

Objective: Acinetobacter species is an important cause of community as well as nosocomial infections with a high mortality rate. The study was done to analyze the risk factors associated with Acinetobacter infections and their outcomes. Methods: The clinical details of 100 patients having infections with Acinetobacter species over a period of 1-year were analyzed for underlying risk factors and outcomes. The antibiotic sensitivity results were interpreted according to the Clinical Laboratory Standards Institute guidelines. Results: Majority of the infections caused by the Acinetobacter species were lower respiratory tract infections, most common being ventilator-associated pneumonia. 47% of the isolates were multi drug resistant and 26% were extensively drug resistant. There is a significant chance of drug resistance and a poor outcome with intensive care unit (ICU) stay, prolonged hospital stay of more than 7 days, the presence of 5 or more risk factors. Endotracheal intubation and mechanical ventilation were the risk factors for increased drug resistance in the ICU. Drug resistance was also seen more frequently in patients with chronic obstructive pulmonary disease, chronic kidney disease, and patients on post-operative care. Conclusion: The steady increase in drug resistant Acinetobacter species and limited antibiotics available advocates an uncompromising approach toward infection control and a judicious use of antibiotics especially in the ICU. An understanding about the risk factors helps in the appropriate approach and management of the patient.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number3
DOIs
Publication statusPublished - 01-03-2017

Fingerprint

Acinetobacter Infections
Drug Resistance
Intensive Care Units
Acinetobacter
Anti-Bacterial Agents
Pharmaceutical Preparations
Ventilator-Associated Pneumonia
Intratracheal Intubation
Infection Control
Cross Infection
Chronic Renal Insufficiency
Artificial Respiration
Respiratory Tract Infections
Chronic Obstructive Pulmonary Disease
Length of Stay
Guidelines
Mortality

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

@article{8c839ae12dbc40fa9ddbd71e40a4d75a,
title = "A rising threat – Risk factors and outcomes related to infections with Acinetobacter species",
abstract = "Objective: Acinetobacter species is an important cause of community as well as nosocomial infections with a high mortality rate. The study was done to analyze the risk factors associated with Acinetobacter infections and their outcomes. Methods: The clinical details of 100 patients having infections with Acinetobacter species over a period of 1-year were analyzed for underlying risk factors and outcomes. The antibiotic sensitivity results were interpreted according to the Clinical Laboratory Standards Institute guidelines. Results: Majority of the infections caused by the Acinetobacter species were lower respiratory tract infections, most common being ventilator-associated pneumonia. 47{\%} of the isolates were multi drug resistant and 26{\%} were extensively drug resistant. There is a significant chance of drug resistance and a poor outcome with intensive care unit (ICU) stay, prolonged hospital stay of more than 7 days, the presence of 5 or more risk factors. Endotracheal intubation and mechanical ventilation were the risk factors for increased drug resistance in the ICU. Drug resistance was also seen more frequently in patients with chronic obstructive pulmonary disease, chronic kidney disease, and patients on post-operative care. Conclusion: The steady increase in drug resistant Acinetobacter species and limited antibiotics available advocates an uncompromising approach toward infection control and a judicious use of antibiotics especially in the ICU. An understanding about the risk factors helps in the appropriate approach and management of the patient.",
author = "Prerna Khurana and Shrikala Baliga and {Suchitra Shenoy}, M. and {Prasanna Mithra}, P.",
year = "2017",
month = "3",
day = "1",
doi = "10.22159/ajpcr.2017.v10i3.15364",
language = "English",
volume = "10",
pages = "108--111",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "3",

}

A rising threat – Risk factors and outcomes related to infections with Acinetobacter species. / Khurana, Prerna; Baliga, Shrikala; Suchitra Shenoy, M.; Prasanna Mithra, P.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 3, 01.03.2017, p. 108-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A rising threat – Risk factors and outcomes related to infections with Acinetobacter species

AU - Khurana, Prerna

AU - Baliga, Shrikala

AU - Suchitra Shenoy, M.

AU - Prasanna Mithra, P.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective: Acinetobacter species is an important cause of community as well as nosocomial infections with a high mortality rate. The study was done to analyze the risk factors associated with Acinetobacter infections and their outcomes. Methods: The clinical details of 100 patients having infections with Acinetobacter species over a period of 1-year were analyzed for underlying risk factors and outcomes. The antibiotic sensitivity results were interpreted according to the Clinical Laboratory Standards Institute guidelines. Results: Majority of the infections caused by the Acinetobacter species were lower respiratory tract infections, most common being ventilator-associated pneumonia. 47% of the isolates were multi drug resistant and 26% were extensively drug resistant. There is a significant chance of drug resistance and a poor outcome with intensive care unit (ICU) stay, prolonged hospital stay of more than 7 days, the presence of 5 or more risk factors. Endotracheal intubation and mechanical ventilation were the risk factors for increased drug resistance in the ICU. Drug resistance was also seen more frequently in patients with chronic obstructive pulmonary disease, chronic kidney disease, and patients on post-operative care. Conclusion: The steady increase in drug resistant Acinetobacter species and limited antibiotics available advocates an uncompromising approach toward infection control and a judicious use of antibiotics especially in the ICU. An understanding about the risk factors helps in the appropriate approach and management of the patient.

AB - Objective: Acinetobacter species is an important cause of community as well as nosocomial infections with a high mortality rate. The study was done to analyze the risk factors associated with Acinetobacter infections and their outcomes. Methods: The clinical details of 100 patients having infections with Acinetobacter species over a period of 1-year were analyzed for underlying risk factors and outcomes. The antibiotic sensitivity results were interpreted according to the Clinical Laboratory Standards Institute guidelines. Results: Majority of the infections caused by the Acinetobacter species were lower respiratory tract infections, most common being ventilator-associated pneumonia. 47% of the isolates were multi drug resistant and 26% were extensively drug resistant. There is a significant chance of drug resistance and a poor outcome with intensive care unit (ICU) stay, prolonged hospital stay of more than 7 days, the presence of 5 or more risk factors. Endotracheal intubation and mechanical ventilation were the risk factors for increased drug resistance in the ICU. Drug resistance was also seen more frequently in patients with chronic obstructive pulmonary disease, chronic kidney disease, and patients on post-operative care. Conclusion: The steady increase in drug resistant Acinetobacter species and limited antibiotics available advocates an uncompromising approach toward infection control and a judicious use of antibiotics especially in the ICU. An understanding about the risk factors helps in the appropriate approach and management of the patient.

UR - http://www.scopus.com/inward/record.url?scp=85014741981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014741981&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2017.v10i3.15364

DO - 10.22159/ajpcr.2017.v10i3.15364

M3 - Article

AN - SCOPUS:85014741981

VL - 10

SP - 108

EP - 111

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 3

ER -