A Sensitive High Performance Liquid Chromatography Method for Determination of Bioequivalence of Atenolol Formulations

S. A. Shah, I. S. Rathod, C. J. Shishoo, S. S. Savale, M. C. Satia, K. M. Bhat

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A sensitive and specific HPLC method with fluorescence detector has been developed for the analysis of atenolol in plasma using a reverse phase column (ODS, 250 × 4.6 mm, 10 μm). Atenolol levels were measured using its excitation and emission maxima at 276 nm and 302 nm, respectively. The method has a linearity range of 50-1000 ng/ml and recovery was found to be 95.7%. This method has been successfully used for the bioequivalence study of atenolol tablets (25 mg). Cmax, tmax and AUC0-∞ of the test formulation statistically does not show significant difference from the standard formulation.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume62
Issue number3
Publication statusPublished - 01-05-2000

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Therapeutic Equivalency
Atenolol
High Pressure Liquid Chromatography
Tablets
Fluorescence

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Shah, S. A. ; Rathod, I. S. ; Shishoo, C. J. ; Savale, S. S. ; Satia, M. C. ; Bhat, K. M. / A Sensitive High Performance Liquid Chromatography Method for Determination of Bioequivalence of Atenolol Formulations. In: Indian Journal of Pharmaceutical Sciences. 2000 ; Vol. 62, No. 3. pp. 187-192.
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A Sensitive High Performance Liquid Chromatography Method for Determination of Bioequivalence of Atenolol Formulations. / Shah, S. A.; Rathod, I. S.; Shishoo, C. J.; Savale, S. S.; Satia, M. C.; Bhat, K. M.

In: Indian Journal of Pharmaceutical Sciences, Vol. 62, No. 3, 01.05.2000, p. 187-192.

Research output: Contribution to journalArticle

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