A simple method to quantify maturation of wound collagen.

C. M. Rao, K. V. Ramesh, K. L. Bairy, D. R. Kulkarni

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

While investigating the effect of NSAIDs and Zn(II) (NSAIDs)2 complexes on healing of dead space wounds we found that both NSAIDs and Zn(II) (NSAIDs)2 reduced collagen content to a comparable extent yet only NSAIDs reduced breaking strength (BS) of wounds. Since collagen content and maturation are the two important determinants of BS it was obvious that only NSAIDs reduced maturation. A simple method to assess the extent of maturation in available collagen is being reported in the present study. While all NSAIDs significantly reduced the maturation of collagen, Zn(II) (NSAIDs)2 complexes per se did not affect the maturation of collagen of 10-day old. Though, chronologically, granulation tissues obtained from both the treated groups were 10-day old, maturation-wise the age of NSAIDs and Zn(II) (NSAIDs)2 treated granulation was 6 and 12 days respectively.

Original languageEnglish
Pages (from-to)156-158
Number of pages3
JournalIndian Journal of Experimental Biology
Volume29
Issue number2
Publication statusPublished - 02-1991

Fingerprint

Non-Steroidal Anti-Inflammatory Agents
Collagen
Wounds and Injuries
Granulation
Tissue
Granulation Tissue

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Rao, C. M., Ramesh, K. V., Bairy, K. L., & Kulkarni, D. R. (1991). A simple method to quantify maturation of wound collagen. Indian Journal of Experimental Biology, 29(2), 156-158.
Rao, C. M. ; Ramesh, K. V. ; Bairy, K. L. ; Kulkarni, D. R. / A simple method to quantify maturation of wound collagen. In: Indian Journal of Experimental Biology. 1991 ; Vol. 29, No. 2. pp. 156-158.
@article{d46199024d3e4146ba48dbeb5b347292,
title = "A simple method to quantify maturation of wound collagen.",
abstract = "While investigating the effect of NSAIDs and Zn(II) (NSAIDs)2 complexes on healing of dead space wounds we found that both NSAIDs and Zn(II) (NSAIDs)2 reduced collagen content to a comparable extent yet only NSAIDs reduced breaking strength (BS) of wounds. Since collagen content and maturation are the two important determinants of BS it was obvious that only NSAIDs reduced maturation. A simple method to assess the extent of maturation in available collagen is being reported in the present study. While all NSAIDs significantly reduced the maturation of collagen, Zn(II) (NSAIDs)2 complexes per se did not affect the maturation of collagen of 10-day old. Though, chronologically, granulation tissues obtained from both the treated groups were 10-day old, maturation-wise the age of NSAIDs and Zn(II) (NSAIDs)2 treated granulation was 6 and 12 days respectively.",
author = "Rao, {C. M.} and Ramesh, {K. V.} and Bairy, {K. L.} and Kulkarni, {D. R.}",
year = "1991",
month = "2",
language = "English",
volume = "29",
pages = "156--158",
journal = "Journal of scientific & industrial research. C. Biological sciences",
issn = "0019-5189",
publisher = "National Institute of Science Communication",
number = "2",

}

Rao, CM, Ramesh, KV, Bairy, KL & Kulkarni, DR 1991, 'A simple method to quantify maturation of wound collagen.', Indian Journal of Experimental Biology, vol. 29, no. 2, pp. 156-158.

A simple method to quantify maturation of wound collagen. / Rao, C. M.; Ramesh, K. V.; Bairy, K. L.; Kulkarni, D. R.

In: Indian Journal of Experimental Biology, Vol. 29, No. 2, 02.1991, p. 156-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A simple method to quantify maturation of wound collagen.

AU - Rao, C. M.

AU - Ramesh, K. V.

AU - Bairy, K. L.

AU - Kulkarni, D. R.

PY - 1991/2

Y1 - 1991/2

N2 - While investigating the effect of NSAIDs and Zn(II) (NSAIDs)2 complexes on healing of dead space wounds we found that both NSAIDs and Zn(II) (NSAIDs)2 reduced collagen content to a comparable extent yet only NSAIDs reduced breaking strength (BS) of wounds. Since collagen content and maturation are the two important determinants of BS it was obvious that only NSAIDs reduced maturation. A simple method to assess the extent of maturation in available collagen is being reported in the present study. While all NSAIDs significantly reduced the maturation of collagen, Zn(II) (NSAIDs)2 complexes per se did not affect the maturation of collagen of 10-day old. Though, chronologically, granulation tissues obtained from both the treated groups were 10-day old, maturation-wise the age of NSAIDs and Zn(II) (NSAIDs)2 treated granulation was 6 and 12 days respectively.

AB - While investigating the effect of NSAIDs and Zn(II) (NSAIDs)2 complexes on healing of dead space wounds we found that both NSAIDs and Zn(II) (NSAIDs)2 reduced collagen content to a comparable extent yet only NSAIDs reduced breaking strength (BS) of wounds. Since collagen content and maturation are the two important determinants of BS it was obvious that only NSAIDs reduced maturation. A simple method to assess the extent of maturation in available collagen is being reported in the present study. While all NSAIDs significantly reduced the maturation of collagen, Zn(II) (NSAIDs)2 complexes per se did not affect the maturation of collagen of 10-day old. Though, chronologically, granulation tissues obtained from both the treated groups were 10-day old, maturation-wise the age of NSAIDs and Zn(II) (NSAIDs)2 treated granulation was 6 and 12 days respectively.

UR - http://www.scopus.com/inward/record.url?scp=0026114226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026114226&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 156

EP - 158

JO - Journal of scientific & industrial research. C. Biological sciences

JF - Journal of scientific & industrial research. C. Biological sciences

SN - 0019-5189

IS - 2

ER -