A study of C-reactive protein and its relationship with CHD and lipid metabolism

R. N. Devaki, H. Basavana Gowdappa, M. N. Suma, V. Prashanth, P. Akila, B. D. Anjali Devi, K. Deepa, B. K. Manjunatha Goud, Bhavna Nayal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inflammation is an important feature of atheroma and is associated with activation and proliferation of macrophages, endothelial and smooth muscle cells, the generation of growth factors and cytokines, the presence of other pro-inflammatory mediators, and the activation and deposition of complement particles. Increased serum CRP levels have been found recently in patients with both myocardial infarction and angina. Many trials have confirmed the association between high levels of CRP and the risk of future coronary events such as myocardial infarction and sudden cardiac death. A total 60 subjects were included in the study in the age group of 50-68 years. Troponin I, hs-CRP, serum total cholesterol, HDL-cholesterol, triglycerides, and VLDL levels were estimated and LDL-cholesterol was calculated by Fried-walds formula. There was a statistically significant difference between the ages of two groups. The total cholesterol and LDL levels were significantly increased in CHD patients as compared to control subjects p<0.001). Unlike other markers of inflammation, C-reactive protein levels are stable over long periods, have no diurnal variation, can be measured inexpensively with available high-sensitivity assays, and have shown specificity in terms of predicting the risk of cardiovascular disease. We conclude that in conjunction with Troponin I values, regular assay of CRP may play a valuable part in differential diagnosis and management of CHD.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume6
Issue number2
Publication statusPublished - 01-01-2011

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Troponin I
Lipid Metabolism
C-Reactive Protein
LDL Cholesterol
Age Groups
Myocardial Infarction
Inflammation
Macrophage Activation
Complement Activation
Sudden Cardiac Death
Atherosclerotic Plaques
Serum
HDL Cholesterol
Smooth Muscle Myocytes
Intercellular Signaling Peptides and Proteins
Differential Diagnosis
Cardiovascular Diseases
Cholesterol
Cytokines
very low density lipoprotein triglyceride

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Devaki, R. N., Basavana Gowdappa, H., Suma, M. N., Prashanth, V., Akila, P., Anjali Devi, B. D., ... Nayal, B. (2011). A study of C-reactive protein and its relationship with CHD and lipid metabolism. International Journal of Pharmaceutical Sciences Review and Research, 6(2), 125-127.
Devaki, R. N. ; Basavana Gowdappa, H. ; Suma, M. N. ; Prashanth, V. ; Akila, P. ; Anjali Devi, B. D. ; Deepa, K. ; Manjunatha Goud, B. K. ; Nayal, Bhavna. / A study of C-reactive protein and its relationship with CHD and lipid metabolism. In: International Journal of Pharmaceutical Sciences Review and Research. 2011 ; Vol. 6, No. 2. pp. 125-127.
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Devaki, RN, Basavana Gowdappa, H, Suma, MN, Prashanth, V, Akila, P, Anjali Devi, BD, Deepa, K, Manjunatha Goud, BK & Nayal, B 2011, 'A study of C-reactive protein and its relationship with CHD and lipid metabolism', International Journal of Pharmaceutical Sciences Review and Research, vol. 6, no. 2, pp. 125-127.

A study of C-reactive protein and its relationship with CHD and lipid metabolism. / Devaki, R. N.; Basavana Gowdappa, H.; Suma, M. N.; Prashanth, V.; Akila, P.; Anjali Devi, B. D.; Deepa, K.; Manjunatha Goud, B. K.; Nayal, Bhavna.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 6, No. 2, 01.01.2011, p. 125-127.

Research output: Contribution to journalArticle

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AU - Devaki, R. N.

AU - Basavana Gowdappa, H.

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AU - Deepa, K.

AU - Manjunatha Goud, B. K.

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AB - Inflammation is an important feature of atheroma and is associated with activation and proliferation of macrophages, endothelial and smooth muscle cells, the generation of growth factors and cytokines, the presence of other pro-inflammatory mediators, and the activation and deposition of complement particles. Increased serum CRP levels have been found recently in patients with both myocardial infarction and angina. Many trials have confirmed the association between high levels of CRP and the risk of future coronary events such as myocardial infarction and sudden cardiac death. A total 60 subjects were included in the study in the age group of 50-68 years. Troponin I, hs-CRP, serum total cholesterol, HDL-cholesterol, triglycerides, and VLDL levels were estimated and LDL-cholesterol was calculated by Fried-walds formula. There was a statistically significant difference between the ages of two groups. The total cholesterol and LDL levels were significantly increased in CHD patients as compared to control subjects p<0.001). Unlike other markers of inflammation, C-reactive protein levels are stable over long periods, have no diurnal variation, can be measured inexpensively with available high-sensitivity assays, and have shown specificity in terms of predicting the risk of cardiovascular disease. We conclude that in conjunction with Troponin I values, regular assay of CRP may play a valuable part in differential diagnosis and management of CHD.

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Devaki RN, Basavana Gowdappa H, Suma MN, Prashanth V, Akila P, Anjali Devi BD et al. A study of C-reactive protein and its relationship with CHD and lipid metabolism. International Journal of Pharmaceutical Sciences Review and Research. 2011 Jan 1;6(2):125-127.