Abstract
BACKGROUND: Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. OBJECTIVE: To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. METHODS: The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. RESULTS: There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. CONCLUSIONS: The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.
| Original language | English |
|---|---|
| Pages (from-to) | 213-216 |
| Number of pages | 4 |
| Journal | The Indian journal of chest diseases & allied sciences |
| Volume | 51 |
| Issue number | 4 |
| Publication status | Published - 01-10-2009 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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A study of high-sensitivity C-reactive protein in bronchial asthma. / Sahoo, Ramesh Chandra; Acharya, Preetam Rajgopal; Noushad, T. H.; Anand, R.; Acharya, Vishak K.; Sahu, Kausalya R.
In: The Indian journal of chest diseases & allied sciences, Vol. 51, No. 4, 01.10.2009, p. 213-216.Research output: Contribution to journal › Article
TY - JOUR
T1 - A study of high-sensitivity C-reactive protein in bronchial asthma.
AU - Sahoo, Ramesh Chandra
AU - Acharya, Preetam Rajgopal
AU - Noushad, T. H.
AU - Anand, R.
AU - Acharya, Vishak K.
AU - Sahu, Kausalya R.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - BACKGROUND: Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. OBJECTIVE: To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. METHODS: The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. RESULTS: There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. CONCLUSIONS: The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.
AB - BACKGROUND: Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. OBJECTIVE: To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. METHODS: The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. RESULTS: There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. CONCLUSIONS: The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.
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M3 - Article
C2 - 20073372
AN - SCOPUS:77449085179
VL - 51
SP - 213
EP - 216
JO - The Indian journal of chest diseases
JF - The Indian journal of chest diseases
SN - 0377-9343
IS - 4
ER -