A study of the haematologic spectrum of myelodysplastic syndrome

Jyoti Kini, Urmila N. Khadilkar, Jyostna P. Dayal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In 31 patients of myelodysplastic syndrome, RAEB-t was the commones: subtype (29%), and RARS, the lease common (6.4%); 19.4% were characterised as the unclassifiable (UC) group. Pallor was the dominant sign (90.3%). Low haemoglobin in RA & RARS (p<0.05), thrombocytopenia in RAEB-t (p<0.01) and high leuco/monocyte counts in CMML (p<0.001) were observed. Neutropenia occurred most frequently in RAEB & RAEB-t and circulating blasts in all cases of RAEB-t and CMML. Bicytopenia was the commonest finding (58.1%) and pancytopenia the least (16.1%). 84% of marrows were hypercellular and trilineage dysplasia was seen in 68% of patients. Megaloblastoid dyserythropoiesis was the predominant feature in all cases, dysgranulopoiesis in all cases of RAEB, RAEB-t and CMML, and micromegokaryocytes in all cases of RARS, RAEB & CMML were seen. RAEB-t and RAEB (33.3% each) were the predominant groups which progressed to leukemia, FAB AML-M2, being the commonest type (60%).

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalIndian Journal of Pathology and Microbiology
Volume44
Issue number1
Publication statusPublished - 01-01-2001

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Refractory Anemia with Excess of Blasts
Myelodysplastic Syndromes
Pallor
Pancytopenia
Neutropenia
Thrombocytopenia
Monocytes
Leukemia
Hemoglobins
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

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title = "A study of the haematologic spectrum of myelodysplastic syndrome",
abstract = "In 31 patients of myelodysplastic syndrome, RAEB-t was the commones: subtype (29{\%}), and RARS, the lease common (6.4{\%}); 19.4{\%} were characterised as the unclassifiable (UC) group. Pallor was the dominant sign (90.3{\%}). Low haemoglobin in RA & RARS (p<0.05), thrombocytopenia in RAEB-t (p<0.01) and high leuco/monocyte counts in CMML (p<0.001) were observed. Neutropenia occurred most frequently in RAEB & RAEB-t and circulating blasts in all cases of RAEB-t and CMML. Bicytopenia was the commonest finding (58.1{\%}) and pancytopenia the least (16.1{\%}). 84{\%} of marrows were hypercellular and trilineage dysplasia was seen in 68{\%} of patients. Megaloblastoid dyserythropoiesis was the predominant feature in all cases, dysgranulopoiesis in all cases of RAEB, RAEB-t and CMML, and micromegokaryocytes in all cases of RARS, RAEB & CMML were seen. RAEB-t and RAEB (33.3{\%} each) were the predominant groups which progressed to leukemia, FAB AML-M2, being the commonest type (60{\%}).",
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A study of the haematologic spectrum of myelodysplastic syndrome. / Kini, Jyoti; Khadilkar, Urmila N.; Dayal, Jyostna P.

In: Indian Journal of Pathology and Microbiology, Vol. 44, No. 1, 01.01.2001, p. 9-12.

Research output: Contribution to journalArticle

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