A study of the hematological profile of human immunodeficiency virus positive patients in coastal South Indian Region

Debarshi Saha, Jyoti R. Kini, Reshmi Subramaniam

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. We analyzed the hematological profile in a group of 150 HIV infected patients. Materials and Methods: A retrospective and prospective study of medical records of 150 HIV positive patients at Clinical Pathology laboratory at our institution was done between August 1st and October 15th, 2011 using nonrandom sampling. Hemoglobin (Hb), hematocrit, red cell indices, total leukocyte and differential count, CD4+ and platelet count were noted. Results: Of the 150 patients, 40 (26.67%) were below age 10 and 98 (65.33%) in 21-50 years age group. Eighty-six (57.33%) were females. Hundred patients had anemia (Hb <12 g/dl) of which 58% were microcytic hypochromic (MCHC). Eighteen patients had leukopenia along with anemia. Total number of patients with low CD4 count (<200/μL) was 32 (21.33%) and all had hematological abnormalities, mostly anemias with few leukopenia and thrombocytopenias. All patients with pancytopenia had low CD4+ counts. Total number of patients with thrombocytopenia (<1.5 lacs/dl) was 20 (13.33%). Four patients (2.67%) had pancytopenia. Conclusions: MCHC anemia is the most common morphological variant of anemia. Leukopenia was found to be consistently associated with anemia. Thus, anemia and to a greater extent leukopenia are bad prognostic indicators of disease. Pancytopenia may herald a low CD4+ count.

Original languageEnglish
Pages (from-to)190-193
Number of pages4
JournalJournal of Medical Sciences (Taiwan)
Volume35
Issue number5
DOIs
Publication statusPublished - 01-01-2015

Fingerprint

HIV
Anemia
Leukopenia
CD4 Lymphocyte Count
Pancytopenia
Thrombocytopenia
Hemoglobins
Clinical Pathology
Erythrocyte Indices
Virus Diseases
Viral Load
Platelet Count
Leukocyte Count
Hematocrit
Medical Records
India
Retrospective Studies
Age Groups
Prospective Studies
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{5307f05559d74b2abe819d2c49714434,
title = "A study of the hematological profile of human immunodeficiency virus positive patients in coastal South Indian Region",
abstract = "Introduction: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. We analyzed the hematological profile in a group of 150 HIV infected patients. Materials and Methods: A retrospective and prospective study of medical records of 150 HIV positive patients at Clinical Pathology laboratory at our institution was done between August 1st and October 15th, 2011 using nonrandom sampling. Hemoglobin (Hb), hematocrit, red cell indices, total leukocyte and differential count, CD4+ and platelet count were noted. Results: Of the 150 patients, 40 (26.67{\%}) were below age 10 and 98 (65.33{\%}) in 21-50 years age group. Eighty-six (57.33{\%}) were females. Hundred patients had anemia (Hb <12 g/dl) of which 58{\%} were microcytic hypochromic (MCHC). Eighteen patients had leukopenia along with anemia. Total number of patients with low CD4 count (<200/μL) was 32 (21.33{\%}) and all had hematological abnormalities, mostly anemias with few leukopenia and thrombocytopenias. All patients with pancytopenia had low CD4+ counts. Total number of patients with thrombocytopenia (<1.5 lacs/dl) was 20 (13.33{\%}). Four patients (2.67{\%}) had pancytopenia. Conclusions: MCHC anemia is the most common morphological variant of anemia. Leukopenia was found to be consistently associated with anemia. Thus, anemia and to a greater extent leukopenia are bad prognostic indicators of disease. Pancytopenia may herald a low CD4+ count.",
author = "Debarshi Saha and Kini, {Jyoti R.} and Reshmi Subramaniam",
year = "2015",
month = "1",
day = "1",
doi = "10.4103/1011-4564.167735",
language = "English",
volume = "35",
pages = "190--193",
journal = "Journal of Medical Sciences (Faisalabad)",
issn = "1011-4564",
publisher = "National Defense Medical Center",
number = "5",

}

A study of the hematological profile of human immunodeficiency virus positive patients in coastal South Indian Region. / Saha, Debarshi; Kini, Jyoti R.; Subramaniam, Reshmi.

In: Journal of Medical Sciences (Taiwan), Vol. 35, No. 5, 01.01.2015, p. 190-193.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A study of the hematological profile of human immunodeficiency virus positive patients in coastal South Indian Region

AU - Saha, Debarshi

AU - Kini, Jyoti R.

AU - Subramaniam, Reshmi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. We analyzed the hematological profile in a group of 150 HIV infected patients. Materials and Methods: A retrospective and prospective study of medical records of 150 HIV positive patients at Clinical Pathology laboratory at our institution was done between August 1st and October 15th, 2011 using nonrandom sampling. Hemoglobin (Hb), hematocrit, red cell indices, total leukocyte and differential count, CD4+ and platelet count were noted. Results: Of the 150 patients, 40 (26.67%) were below age 10 and 98 (65.33%) in 21-50 years age group. Eighty-six (57.33%) were females. Hundred patients had anemia (Hb <12 g/dl) of which 58% were microcytic hypochromic (MCHC). Eighteen patients had leukopenia along with anemia. Total number of patients with low CD4 count (<200/μL) was 32 (21.33%) and all had hematological abnormalities, mostly anemias with few leukopenia and thrombocytopenias. All patients with pancytopenia had low CD4+ counts. Total number of patients with thrombocytopenia (<1.5 lacs/dl) was 20 (13.33%). Four patients (2.67%) had pancytopenia. Conclusions: MCHC anemia is the most common morphological variant of anemia. Leukopenia was found to be consistently associated with anemia. Thus, anemia and to a greater extent leukopenia are bad prognostic indicators of disease. Pancytopenia may herald a low CD4+ count.

AB - Introduction: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. We analyzed the hematological profile in a group of 150 HIV infected patients. Materials and Methods: A retrospective and prospective study of medical records of 150 HIV positive patients at Clinical Pathology laboratory at our institution was done between August 1st and October 15th, 2011 using nonrandom sampling. Hemoglobin (Hb), hematocrit, red cell indices, total leukocyte and differential count, CD4+ and platelet count were noted. Results: Of the 150 patients, 40 (26.67%) were below age 10 and 98 (65.33%) in 21-50 years age group. Eighty-six (57.33%) were females. Hundred patients had anemia (Hb <12 g/dl) of which 58% were microcytic hypochromic (MCHC). Eighteen patients had leukopenia along with anemia. Total number of patients with low CD4 count (<200/μL) was 32 (21.33%) and all had hematological abnormalities, mostly anemias with few leukopenia and thrombocytopenias. All patients with pancytopenia had low CD4+ counts. Total number of patients with thrombocytopenia (<1.5 lacs/dl) was 20 (13.33%). Four patients (2.67%) had pancytopenia. Conclusions: MCHC anemia is the most common morphological variant of anemia. Leukopenia was found to be consistently associated with anemia. Thus, anemia and to a greater extent leukopenia are bad prognostic indicators of disease. Pancytopenia may herald a low CD4+ count.

UR - http://www.scopus.com/inward/record.url?scp=84944742030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944742030&partnerID=8YFLogxK

U2 - 10.4103/1011-4564.167735

DO - 10.4103/1011-4564.167735

M3 - Article

VL - 35

SP - 190

EP - 193

JO - Journal of Medical Sciences (Faisalabad)

JF - Journal of Medical Sciences (Faisalabad)

SN - 1011-4564

IS - 5

ER -