A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn)

B. Krupavaram, N. Venkat Rao, K. Nandakumar, T. S. Gowda, Md Shalam, S. M. Shantakumar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa (Linn) was evaluated in albino mice and rats. Mice were subjected to anoxia stress tolerance test for 3 weeks and rats to swimming and cold restraint stress for 10 days. In anoxia stress tolerance test, mean duration of stress tolerance time to anoxia was determined where as in swimming and cold restraint stress methods biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), blood cell count like RBC, WBC, DLC and weights of organs like liver, spleen and adrenal glands were estimated at the end of the stress period. Both alcoholic and chloroform extracts had significantly increased the anoxia stress tolerance time when compared to stress control. In swimming and cold restraint stress models, both the extracts have significantly(P<0.01) reduced the levels of biochemical parameters and blood cell count elevated due to stress and prevented variations in organ weights when compared to stress control animals. The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa was comparable to standard drug withania somnifera.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalIndian Drugs
Volume44
Issue number4
Publication statusPublished - 01-04-2007

Fingerprint

Nyctaginaceae
Chloroform
Organ Size
Blood Cell Count
Exercise Test
Withania
Blood Urea Nitrogen
Adrenal Glands
Triglycerides
Spleen
Cholesterol
Glucose
Hypoxia
Liver
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Krupavaram, B., Venkat Rao, N., Nandakumar, K., Gowda, T. S., Shalam, M., & Shantakumar, S. M. (2007). A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn). Indian Drugs, 44(4), 264-270.
Krupavaram, B. ; Venkat Rao, N. ; Nandakumar, K. ; Gowda, T. S. ; Shalam, Md ; Shantakumar, S. M. / A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn). In: Indian Drugs. 2007 ; Vol. 44, No. 4. pp. 264-270.
@article{acffb673386345d7b25aa0f82928fb9c,
title = "A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn)",
abstract = "The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa (Linn) was evaluated in albino mice and rats. Mice were subjected to anoxia stress tolerance test for 3 weeks and rats to swimming and cold restraint stress for 10 days. In anoxia stress tolerance test, mean duration of stress tolerance time to anoxia was determined where as in swimming and cold restraint stress methods biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), blood cell count like RBC, WBC, DLC and weights of organs like liver, spleen and adrenal glands were estimated at the end of the stress period. Both alcoholic and chloroform extracts had significantly increased the anoxia stress tolerance time when compared to stress control. In swimming and cold restraint stress models, both the extracts have significantly(P<0.01) reduced the levels of biochemical parameters and blood cell count elevated due to stress and prevented variations in organ weights when compared to stress control animals. The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa was comparable to standard drug withania somnifera.",
author = "B. Krupavaram and {Venkat Rao}, N. and K. Nandakumar and Gowda, {T. S.} and Md Shalam and Shantakumar, {S. M.}",
year = "2007",
month = "4",
day = "1",
language = "English",
volume = "44",
pages = "264--270",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "4",

}

Krupavaram, B, Venkat Rao, N, Nandakumar, K, Gowda, TS, Shalam, M & Shantakumar, SM 2007, 'A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn)', Indian Drugs, vol. 44, no. 4, pp. 264-270.

A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn). / Krupavaram, B.; Venkat Rao, N.; Nandakumar, K.; Gowda, T. S.; Shalam, Md; Shantakumar, S. M.

In: Indian Drugs, Vol. 44, No. 4, 01.04.2007, p. 264-270.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn)

AU - Krupavaram, B.

AU - Venkat Rao, N.

AU - Nandakumar, K.

AU - Gowda, T. S.

AU - Shalam, Md

AU - Shantakumar, S. M.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa (Linn) was evaluated in albino mice and rats. Mice were subjected to anoxia stress tolerance test for 3 weeks and rats to swimming and cold restraint stress for 10 days. In anoxia stress tolerance test, mean duration of stress tolerance time to anoxia was determined where as in swimming and cold restraint stress methods biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), blood cell count like RBC, WBC, DLC and weights of organs like liver, spleen and adrenal glands were estimated at the end of the stress period. Both alcoholic and chloroform extracts had significantly increased the anoxia stress tolerance time when compared to stress control. In swimming and cold restraint stress models, both the extracts have significantly(P<0.01) reduced the levels of biochemical parameters and blood cell count elevated due to stress and prevented variations in organ weights when compared to stress control animals. The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa was comparable to standard drug withania somnifera.

AB - The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa (Linn) was evaluated in albino mice and rats. Mice were subjected to anoxia stress tolerance test for 3 weeks and rats to swimming and cold restraint stress for 10 days. In anoxia stress tolerance test, mean duration of stress tolerance time to anoxia was determined where as in swimming and cold restraint stress methods biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), blood cell count like RBC, WBC, DLC and weights of organs like liver, spleen and adrenal glands were estimated at the end of the stress period. Both alcoholic and chloroform extracts had significantly increased the anoxia stress tolerance time when compared to stress control. In swimming and cold restraint stress models, both the extracts have significantly(P<0.01) reduced the levels of biochemical parameters and blood cell count elevated due to stress and prevented variations in organ weights when compared to stress control animals. The adaptogenic activity of alcoholic and chloroform extracts of roots of B. diffusa was comparable to standard drug withania somnifera.

UR - http://www.scopus.com/inward/record.url?scp=65949112403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65949112403&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:65949112403

VL - 44

SP - 264

EP - 270

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 4

ER -

Krupavaram B, Venkat Rao N, Nandakumar K, Gowda TS, Shalam M, Shantakumar SM. A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn). Indian Drugs. 2007 Apr 1;44(4):264-270.