A study on proteolytic enzyme activity in the erythrocytes of diabetic patients

B. S. Varashree, P. Gopalakrishna Bhat

Research output: Contribution to journalArticle

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Abstract

The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell.

Original languageEnglish
JournalOnline Journal of Health and Allied Sciences
Volume9
Issue number4
Publication statusPublished - 2010

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Hemoglobins
Peptide Hydrolases
Erythrocytes
Proteins
phenylhydrazine

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell.",
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A study on proteolytic enzyme activity in the erythrocytes of diabetic patients. / Varashree, B. S.; Gopalakrishna Bhat, P.

In: Online Journal of Health and Allied Sciences, Vol. 9, No. 4, 2010.

Research output: Contribution to journalArticle

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AB - The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell.

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