Background: Cancer is an important health issue. According to the WHO report, globally, cervical cancer comprises 12% of all cancers in women and it is the leading gynaecological malignancy in the world. In many developing countries, it is the most common cancer among women where 85% of the estimated 493 000 new cases and 273 000 deaths in 2002 occurred worldwide. Objectives: 1. To study the association between cervical cancer and parity. 2. To study the association between cervical cancer and other selected exposure variables. Settings and design: A hospital based case-control study was conducted in Shirdi Sai Baba Cancer Hospital and Research Centre, Manipal, Udupi District. Methods and material: A total of 273 participants (91 cases and 182 controls) were included. Information on demographics, habits, reproductive history, sexual history and menstrual history was taken using a semi-structured questionnaire. Statistical analysis used: Data was analysed using SPSS version 15. Univariate and Multivariate logistic regression was used to find out the association between the outcome and exposure variables. Results are expressed in odds ratio. Results: Marital status (married) is an important risk factor for cervical cancer, OR = 2.98 (1.23-7.20). People having history of alcohol use were at 4.55 (1.17-17.73) times at risk of developing cervical cancer when compared to those who did not use alcohol. Age at menarche of 13-14. years was found to be a significant risk factor of cervical cancer with OR of 2.91(1.18-7.20). Age at 1st coitus of <18. years had an odds ratio of 5.44(2.73-6.38) and was significantly associated. At least one abortion is an important risk factor with odds of 2.61 (1.70-18.96). Also, adjusted odds ratio for parity of 3-5 was 3.16 (1.12-8.91) and 5.57 (1.70-18.96) for women having ≥6 parity when compared to women having parity of less than 3 and was statistically significant. Conclusions: The study showed that marital status, history of alcohol use, <18 years of age at first coitus, age at menarche and parity of >3 as risk factors of cervical cancer.
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
- Microbiology (medical)
- Infectious Diseases