Aberrantly elevated glycated hemoglobin in a patient with hereditary persistence of fetal hemoglobin

A case report

K. Sudha, K. Ashok Prabhu, Shivangi Rajput

Research output: Contribution to journalArticle

Abstract

Several labs and patient related factors can result in falsely increased or decreased glycated hemoglobin values. The presence of hemoglobin variants is one of the most important factors. We report a rare case of persistent fetal hemoglobin manifesting as a falsely high HbA1c in a 55-year-old lady with coronary artery disease. Her blood glucose level was normal(RBS was 111mg/dL) though HbA1c was incongruently high (57.1%) by HPLC. Further, hematological investigations and Hb variant analysis revealed that she had hereditary persistence of hemoglobin F(HPFH). Her actual HbA1c was found to be 5.9% by the immunoturbidimetric method. It is important for clinicians to be aware of the factors that could affect glycated Hb estimations in the laboratory, as clinical treatment is often based on lab data.

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalBiomedicine (India)
Volume37
Issue number3
Publication statusPublished - 01-07-2017

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Fetal Hemoglobin
Glycosylated Hemoglobin A
Blood Glucose
Coronary Artery Disease
Hemoglobins
High Pressure Liquid Chromatography
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Several labs and patient related factors can result in falsely increased or decreased glycated hemoglobin values. The presence of hemoglobin variants is one of the most important factors. We report a rare case of persistent fetal hemoglobin manifesting as a falsely high HbA1c in a 55-year-old lady with coronary artery disease. Her blood glucose level was normal(RBS was 111mg/dL) though HbA1c was incongruently high (57.1{\%}) by HPLC. Further, hematological investigations and Hb variant analysis revealed that she had hereditary persistence of hemoglobin F(HPFH). Her actual HbA1c was found to be 5.9{\%} by the immunoturbidimetric method. It is important for clinicians to be aware of the factors that could affect glycated Hb estimations in the laboratory, as clinical treatment is often based on lab data.",
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Aberrantly elevated glycated hemoglobin in a patient with hereditary persistence of fetal hemoglobin : A case report. / Sudha, K.; Ashok Prabhu, K.; Rajput, Shivangi.

In: Biomedicine (India), Vol. 37, No. 3, 01.07.2017, p. 441-443.

Research output: Contribution to journalArticle

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